Electrical Coordinated Reset Stimulation Induces Network Desynchronization in an in Vivo Model of Status Epilepticus DOI Open Access
Daniel Ehrens, Fadi Aeed, Yara Otor

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract Epilepsy, a neurological disorder characterized by recurrent seizures, profoundly impacts individuals worldwide. Various electrical stimulation protocols have been investigated to mitigate epileptic among which Coordinated Reset (CR) may potential for inducing long-lasting neural desynchronization. This study explores the acute effects of CR on synchronization dynamics during Status Epilepticus (SE) in an vivo animal model. An electrographically sustained seizure-state was induced via 4-aminopyridine (4AP) administration CA3. Custom-designed electrode probes were implanted facilitate simultaneous recording and stimulation. Analytical univariate bivariate features constructed from LFP time-series recording. Feature metrics focused spike continuous signal analysis amplitude, spectral power phase across pairs frequency bands. Significance modulation assessed through permutation testing observed differences between CR-stimulated group (N=5) compared control (no stimulation) (N=3) SE. Results showed overall decrease amplitude features, significant connectivity measures spectrum group. Our findings underscore effectiveness attenuating excessive synchronization, paving way further exploration as viable intervention network desynchronization epileptiform activity subsequently treatment seizures.

Язык: Английский

Disruptions in cellular communication: Molecular interplay between glutamate/NMDA signalling and MAPK pathways in neurological disorders DOI
Sumedha Gupta, Abhishek Gupta, Sidharth Mehan

и другие.

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Synchronization in multiplex neural networks with homeostatic structural plasticity DOI
Xueyan Hu, Qianming Ding, Yong Wu

и другие.

Chinese Journal of Physics, Год журнала: 2024, Номер 92, С. 946 - 958

Опубликована: Окт. 30, 2024

Язык: Английский

Процитировано

4
Electrical Coordinated Reset stimulation induces network desynchronization in an in vivo model of status epilepticus DOI Creative Commons
Daniel Ehrens, Fadi Aeed, Yara Otor

и другие.

Epilepsy & Behavior, Год журнала: 2025, Номер 165, С. 110300 - 110300

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

0
Dynamic effects of discrete hyperchaotic map-simulated noise in a non-autonomous memristive HR model DOI
Lilian Huang,

Feiyi Geng,

Xihong Yu

и другие.

The European Physical Journal Special Topics, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

Язык: Английский

Процитировано

0
Electrical Coordinated Reset Stimulation Induces Network Desynchronization in an in Vivo Model of Status Epilepticus DOI Open Access
Daniel Ehrens, Fadi Aeed, Yara Otor

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract Epilepsy, a neurological disorder characterized by recurrent seizures, profoundly impacts individuals worldwide. Various electrical stimulation protocols have been investigated to mitigate epileptic among which Coordinated Reset (CR) may potential for inducing long-lasting neural desynchronization. This study explores the acute effects of CR on synchronization dynamics during Status Epilepticus (SE) in an vivo animal model. An electrographically sustained seizure-state was induced via 4-aminopyridine (4AP) administration CA3. Custom-designed electrode probes were implanted facilitate simultaneous recording and stimulation. Analytical univariate bivariate features constructed from LFP time-series recording. Feature metrics focused spike continuous signal analysis amplitude, spectral power phase across pairs frequency bands. Significance modulation assessed through permutation testing observed differences between CR-stimulated group (N=5) compared control (no stimulation) (N=3) SE. Results showed overall decrease amplitude features, significant connectivity measures spectrum group. Our findings underscore effectiveness attenuating excessive synchronization, paving way further exploration as viable intervention network desynchronization epileptiform activity subsequently treatment seizures.

Язык: Английский

Процитировано

0