Phenotypic and Developmental Dissection of an Instance of the Island Rule DOI Creative Commons
Mark J. Nolte, Bret A. Payseur

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Organismal body weight correlates with morphology, life history, physiology, and behavior, making it perhaps the most telling single indicator of an organism’s evolutionary ecological profile. Island populations provide exceptional opportunity to study evolution. In accord “island rule,” insular small-bodied vertebrates often evolve larger sizes, whereas large-bodied smaller sizes. To understand how island extreme we adopted a developmental perspective compared suite traits established connections size in world’s largest wild house mice from Gough smaller-bodied mainland strain. We pinpoint 24-hour periods during third fifth week age which gain exceptionally more than mice. show that accumulate visceral fat beginning early postnatal development. During burst gain, shift toward carbohydrates away as fuel, despite being active consuming equivalent amounts food Our findings showcase value phenotypic characterization for discovering evolves context broader patterns trait

Язык: Английский

Tissue-specific and cis-regulatory changes underlie parallel, adaptive gene expression evolution in house mice DOI Creative Commons
Sylvia M. Durkin, Mallory A. Ballinger, Michael W. Nachman

и другие.

PLoS Genetics, Год журнала: 2024, Номер 20(2), С. e1010892 - e1010892

Опубликована: Фев. 2, 2024

Changes in gene regulation have long been appreciated as a driving force of adaptive evolution, however the relative contributions cis- and trans- acting changes to over short evolutionary timescales remain unclear. Instances recent, parallel phenotypic evolution provide an opportunity assess whether patterns are seen at level expression, contribution cis - trans early stages divergence. Here, we studied expression liver brown adipose tissue two wild-derived strains house mice that independently adapted cold, northern environments, compared them strain from warm, tropical environment. To investigate regulatory parents allele-specific F1 hybrids crosses between warm-adapted cold-adapted strains. First, found different showed both unique shared but proportion (i.e. parallelism) was greater than expected by chance. Second, discovered occurred largely tissue-specific -regulated genes, these genes were over-represented cases evolution. Finally, integrated data with scans for selection natural populations substantial parallelism under selection. Furthermore, outliers associated more chance; influenced phenotypes such body size, immune functioning, activity level. These results demonstrate cold environments driven -regulatory changes, providing insight into mechanisms earliest

Язык: Английский

Процитировано

8
Phenotypic and Developmental Dissection of an Instance of the Island Rule DOI Creative Commons
Mark J. Nolte, Bret A. Payseur

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Organismal body weight correlates with morphology, life history, physiology, and behavior, making it perhaps the most telling single indicator of an organism’s evolutionary ecological profile. Island populations provide exceptional opportunity to study evolution. In accord “island rule,” insular small-bodied vertebrates often evolve larger sizes, whereas large-bodied smaller sizes. To understand how island extreme we adopted a developmental perspective compared suite traits established connections size in world’s largest wild house mice from Gough smaller-bodied mainland strain. We pinpoint 24-hour periods during third fifth week age which gain exceptionally more than mice. show that accumulate visceral fat beginning early postnatal development. During burst gain, shift toward carbohydrates away as fuel, despite being active consuming equivalent amounts food Our findings showcase value phenotypic characterization for discovering evolves context broader patterns trait

Язык: Английский

Процитировано

0