From conservation to adaptation: understanding the synaptonemal complex’s evolutionary dynamics
Current Opinion in Genetics & Development,
Год журнала:
2025,
Номер
93, С. 102349 - 102349
Опубликована: Апрель 17, 2025
The
synaptonemal
complex
(SC)
is
structurally
conserved
across
eukaryotes
and
essential
for
a
proper
progression
of
meiosis.
Despite
this
conservation,
SC
protein
sequences
diverge
drastically.
In
review,
we
explore
findings
on
evolution,
highlighting
key
differences
commonalities
among
lineages
like
the
Caenorhabditis
Drosophila
genera.
We
further
known
cases
where
its
proteins
adopt
novel
functional
roles
discuss
why
knowledge
these
could
be
important
study
canonical
biology.
existing
studies
demonstrate
that
work
evolutionary
biology
in
more
diverse
meiotic
research
organisms
should
play
major
role
aiding
our
understanding
structure
functions.
Язык: Английский
Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species
PLoS Genetics,
Год журнала:
2024,
Номер
20(6), С. e1011329 - e1011329
Опубликована: Июнь 24, 2024
Precise
regulation
of
chromosome
dynamics
in
the
germline
is
essential
for
reproductive
success
across
species.
Yet,
mechanisms
underlying
meiotic
chromosomal
events
such
as
homolog
pairing
and
segregation
are
not
fully
understood
many
Here,
we
employ
Oligopaint
DNA
FISH
to
investigate
holocentric
pantry
moth,
Plodia
interpunctella
,
compare
our
findings
new
previous
studies
silkworm
Bombyx
mori
which
diverged
from
P
.
over
100
million
years
ago.
We
find
that
both
spermatogenesis
initiated
at
gene-rich
ends.
Additionally,
species
form
rod
shaped
cruciform-like
bivalents
metaphase
I.
However,
unlike
telomere-oriented
mechanism
observed
can
orient
multiple
different
ways
Surprisingly,
kinetochores
consistently
assemble
non-telomeric
loci
toward
center
chromosomes
regardless
where
centers
located
bivalent.
sister
do
seem
be
paired
these
Instead,
four
distinct
easily
Despite
this,
clear
end-on
microtubule
attachments
lateral
co-orienting
separated
kinetochores.
These
challenge
classical
view
paired,
poleward-facing
required
accurate
separation
meiosis
Our
here
highlight
importance
exploring
fundamental
processes
non-model
systems,
employing
novel
organisms
lead
discovery
biology.
Язык: Английский
The functional organisation of the centromere and kinetochore during meiosis
Current Opinion in Cell Biology,
Год журнала:
2025,
Номер
94, С. 102486 - 102486
Опубликована: Фев. 26, 2025
Язык: Английский
Unusual modes of cell and nuclear divisions characterise Drosophila development
Biochemical Society Transactions,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
The
growth
and
development
of
metazoan
organisms
is
dependent
upon
a
co-ordinated
programme
cellular
proliferation
differentiation,
from
the
initial
formation
zygote
through
to
maintenance
mature
organs
in
adult
organisms.
Early
studies
ex
vivo
cultures
unicellular
eukaryotes
described
cyclic
nature
cell
division
characterised
by
periods
DNA
synthesis
(S-phase)
segregation
newly
synthesized
chromosomes
(M-phase)
interspersed
seeming
inactivity,
gap
phases,
G1
G2.
We
now
know
that
G2
play
critical
roles
regulating
cycle,
including
monitoring
favourable
environmental
conditions
facilitate
division,
ensuring
genomic
integrity
prior
replication
nuclear
division.
M-phase
usually
followed
physical
separation
nascent
daughters,
termed
cytokinesis.
These
phases
where
leads
S
phase,
M
phase
subsequent
cytokinesis
produce
two
both
identical
composition
morphology
are
what
might
be
an
archetypal
Studies
many
different
species
have
demonstrated
this
stereotypical
cycle
often
subverted
specific
developmental
outcomes,
examples
over
100
years
analysis
Drosophila
melanogaster
uncovered
modes
within
one
species.
Язык: Английский