Sexual recombination in cereal rust fungi: Knowns and unknowns of pathogen evolution and adaptation
PLoS Pathogens,
Год журнала:
2025,
Номер
21(2), С. e1012908 - e1012908
Опубликована: Фев. 4, 2025
Язык: Английский
Genome biology and evolution of mating-type loci in four cereal rust fungi
PLoS Genetics,
Год журнала:
2024,
Номер
20(3), С. e1011207 - e1011207
Опубликована: Март 18, 2024
Permanent
heterozygous
loci,
such
as
sex-
or
mating-compatibility
regions,
often
display
suppression
of
recombination
and
signals
genomic
degeneration.
In
Basidiomycota,
two
distinct
loci
confer
mating
compatibility.
These
encode
homeodomain
(
HD
)
transcription
factors
pheromone
receptor
Pra
)-ligand
allele
pairs.
To
date,
an
analysis
genome
level
mating-type
(MAT)
is
lacking
for
obligate
biotrophic
basidiomycetes
in
the
Pucciniales
,
order
containing
serious
agricultural
plant
pathogens.
Here,
we
focus
on
four
species
Puccinia
that
infect
oat
wheat,
including
P
.
coronata
f.
sp.
avenae
graminis
tritici
triticina
striiformis
MAT
are
located
separate
chromosomes
supporting
previous
hypotheses
a
tetrapolar
compatibility
system
The
genes
multiallelic
all
while
PR
locus
appears
biallelic,
except
which
potentially
has
multiple
alleles.
largely
conserved
their
macrosynteny,
both
within
between
species,
without
strong
suppression.
Regions
proximal
to
locus,
however,
displayed
signs
degeneration
three
with
biallelic
locus.
Our
observations
support
link
suppression,
degeneration,
diversity
consistent
recent
mathematical
modelling
simulations.
Finally,
confirm
expressed
during
asexual
infection
cycle,
propose
this
may
regulating
nuclear
maintenance
pairing
spore
formation.
study
provides
insights
into
evolution
key
pathogenic
species.
Understanding
can
help
predict
possible
combinations
pairs,
generated
by
sexual
reproduction
somatic
recombination,
potential
new
virulent
isolates
these
important
Язык: Английский
A high-resolution haplotype pangenome uncovers somatic hybridization, recombination and intercontinental migration in oat crown rust
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 27, 2024
Abstract
Basidiomycetes
like
rust
fungi
have
complex
reproductive
cycles
and
dikaryotic
life
stages
which
influence
their
population
structure
evolution.
Puccinia
coronata
f.
sp.
avenae
(
Pca
),
the
causal
agent
of
oat
crown
rust,
is
a
pathogen
global
economic
importance.
To
investigate
genetic
diversity
species,
as
well
role
mating
type
system
nuclear
exchange
(somatic
hybridization)
in
host
adaptation
we
acquired
whole
genome
sequencing
data
Taiwanese
Australian
isolates,
adding
to
existing
for
USA
South
African
populations.
An
atlas
30
chromosome-level,
fully-phased
haplotypes
from
six
isolates
nine
was
generated
capture
genomic
composition
key
lineages.
This
study
provides
evidence
recombination
both
populations
mechanisms
introduction
diversity.
The
limitations
assuming
clonal
evolutionary
history
virulence
phenotyping
demonstrated
by
detection
either
sexual
or
cryptic
population.
Overall,
characterization
intercontinental
migration
at
haplotype
level
further
impetus
molecular
monitoring
on
scale.
Язык: Английский
Uncovering the history of recombination and population structure in western Canadian stripe rust populations through mating type alleles
BMC Biology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Окт. 25, 2023
The
population
structure
of
crop
pathogens
such
as
Puccinia
striiformis
f.
sp.
tritici
(Pst),
the
cause
wheat
stripe
rust,
is
interest
to
researchers
looking
understand
these
on
a
molecular
level
well
those
with
an
applied
focus
disease
epidemiology.
Cereal
rusts
can
reproduce
sexually
or
asexually,
and
emergence
novel
lineages
has
potential
serious
epidemics
one
caused
by
'Warrior'
lineage
in
Europe.
In
global
context,
Pst
Canada
were
not
well-characterized
origin
foreign
incursions
was
known.
Additionally,
while
some
mating
type
genes
have
been
identified
published
genomes,
there
no
rigorous
assessment
diversity
distribution
across
species.
Язык: Английский
Dynamics of transposable element accumulation in the non-recombining regions of mating-type chromosomes in anther-smut fungi
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Сен. 14, 2023
In
the
absence
of
recombination,
number
transposable
elements
(TEs)
increases
due
to
less
efficient
selection,
but
dynamics
such
TE
accumulations
are
not
well
characterized.
Leveraging
a
dataset
21
independent
events
recombination
cessation
different
ages
in
mating-type
chromosomes
Microbotryum
fungi,
we
show
that
TEs
rapidly
accumulated
regions
lacking
content
reached
plateau
at
ca.
50%
occupied
base
pairs
by
1.5
million
years
following
suppression.
The
same
superfamilies
have
expanded
independently
evolved
non-recombining
regions,
particular
rolling-circle
replication
(Helitrons).
Long-terminal
repeat
(LTR)
retrotransposons
Copia
and
Ty3
also
expanded,
through
transposition
bursts
(distinguished
from
gene
conversion
based
on
LTR
divergence),
with
both
autosomes
affected,
suggesting
constitute
reservoirs.
This
study
improves
our
knowledge
genome
evolution
showing
can
accumulate
bursts,
non-linear
decelerating
dynamics.
Язык: Английский
A high-resolution haplotype collection uncovers somatic hybridization, recombination and intercontinental movement in oat crown rust
PLoS Genetics,
Год журнала:
2024,
Номер
20(11), С. e1011493 - e1011493
Опубликована: Ноя. 21, 2024
The
population
structure
and
evolution
of
basidiomycetes
like
rust
fungi
are
influenced
by
complex
reproductive
cycles
dikaryotic
life
stages
where
two
independent
nuclear
haplotypes
present
in
the
cell.
ability
to
alternate
between
asexual
(clonal)
sexual
reproduction
increases
evolutionary
capacity
these
species.
Furthermore,
exchange
intact
nuclei
(somatic
hybridization)
can
allow
for
rapid
generation
genetic
variability
outside
cycle.
Puccinia
coronata
f.
sp.
avenae
(Pca),
causal
agent
oat
crown
rust,
is
a
pathogen
global
economic
importance
that
difficult
control
due
breakdown
host
resistance.
contribution
sexuality,
clonality,
migration
virulence
varies
across
Pca
populations.
As
such,
pathosystem
ideal
address
role
mating
type,
recombination,
mutation,
somatic
hybridization
adaptation.
We
expanded
existing
resources
USA
South
African
populations
generating
whole
genome
sequencing
data
Taiwanese
Australian
isolates.
An
atlas
30
chromosome-level,
fully-phased
from
six
isolates
nine
was
created
capture
genomic
composition
key
lineages.
At
haplotype
level,
we
confirmed
previous
reports
recombination
additionally
detected
either
or
cryptic
isolates,
contrasting
evaluations
suggested
Australia
be
purely
clonal.
also
identified
events
not
only
associated
with
significant
changes
fitness
but
imply
intercontinental
haplotypes,
which
provides
further
impetus
molecular
monitoring
on
scale.
Язык: Английский
Uncovering the Mechanisms: The Role of Biotrophic Fungi in Activating or Suppressing Plant Defense Responses
Journal of Fungi,
Год журнала:
2024,
Номер
10(9), С. 635 - 635
Опубликована: Сен. 5, 2024
This
paper
discusses
the
mechanisms
by
which
fungi
manipulate
plant
physiology
and
suppress
defense
responses
producing
effectors
that
can
target
various
host
proteins.
Effector-triggered
immunity
effector-triggered
susceptibility
are
pivotal
elements
in
complex
molecular
dialogue
underlying
plant-pathogen
interactions.
Pathogen-produced
effector
molecules
possess
ability
to
mimic
pathogen-associated
patterns
or
hinder
binding
of
pattern
recognition
receptors.
Effectors
directly
nucleotide-binding
domain,
leucine-rich
repeat
receptors,
downstream
signaling
components
defense.
Interactions
between
these
receptor-like
kinases
plants
critical
this
process.
Biotrophic
adeptly
exploit
networks
key
hormones,
including
salicylic
acid,
jasmonic
abscisic
ethylene,
establish
a
compatible
interaction
with
their
hosts.
Overall,
highlights
importance
understanding
interplay
fungal
develop
effective
strategies
for
disease
management.
Язык: Английский
Two divergent haploid nuclei shaped the landscape of population diversity in wheat stripe rust
Yibo Wang,
Mou Yin,
Fei He
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Abstract
Heterozygosity
is
a
measure
of
allelic
diversity
within
individuals.
Puccinia
striiformis
f.
sp.
tritici
(
Pst
)
highly
heterozygous
dikaryotic
crop
pathogen.
Its
source
heterozygosity
variation
and
the
contribution
to
adaptability
are
still
unknown.
By
analyzing
resequencing
data
266
worldwide
isolates,
we
found
that
may
have
undergone
an
important
historical
hybridization
event,
introducing
substantial
leading
divergence
its
haploid
genomes
into
two
distinct
haplotypes.
Strains
with
both
haplotypes
exhibit
higher
individual
allele
wider
geographical
distribution.
Between
genomes,
16%
genome
had
diverged,
scattered
as
mosaic
blocks
genome.
These
regions
enriched
genes
displaying
critical
roles
during
infection
plant
host,
expression
levels.
In
these
regions,
8.0
Mb
shows
recombination
fingerprints
associated
virulence,
while
4.9
displays
linkage
across
entire
We
demonstrated
sexual
in
extensive
significant.
can
gain
genetic
due
intra-
inter-species
hybridization.
Our
study
resolved
debate
over
sources
expands
understanding
pathogen
virulence
evolution.
findings
also
suggest
interrupting
reproduction
pathogens
be
effective
strategy
for
controlling
wheat
stripe
rust.
Язык: Английский