Expected and Desirable Preterm and Small Infant Growth Patterns

Advances in Nutrition, Год журнала: 2024, Номер 15(6), С. 100220 - 100220

Опубликована: Апрель 24, 2024

Adequate nutrition is necessary for achieving optimal growth and neurodevelopment. Growth a natural expected process that happens concomitantly with rapid advancements in Serial weight, length, head circumference measures are essential monitoring development, although identifying pathological deviations from normal can pose challenges. Appropriate assessments require considerations range of sizes circumference, weight appropriate. Because genetic differences morbidities, there considerable overlap between the healthy infants those alterations. Parents tend to be over-concerned about children who plot low on charts often need reassurance. Thus, use terms such as "poor" or "failure" discouraged when approximately parallel chart curves even if their size smaller than specific percentiles. No percentile should set goal; individual variability expected. An infant's at birth important information goes beyond common prognostic predictions appropriate compared small large gestational age. The lower birthweight, nutrient stores more support. Compared term infants, preterm term-equivalent age have higher percentage body fat, but this diminishes over next months. Current research findings support expert recommendations grow, after early postnatal loss, similar fetus then term-born which translates curves. There no trade-off optimum cognition future health. Each high-risk infant needs individualized assessments. This review aims examine expectations messaging parents within broader causal framework.

Язык: Английский

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Growth patterns by birth size of preterm children born at 24–29 gestational weeks for the first 3 years

Paediatric and Perinatal Epidemiology, Год журнала: 2024, Номер 38(7), С. 560 - 569

Опубликована: Май 15, 2024

Concerns are prevalent about preterm infant long-term growth regarding plotting low on charts at discharge, stunting, underweight, high body fat and subsequent cardiometabolic morbidities.

Язык: Английский

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Body Composition in Adults Born at Very Low Birthweight—A Sibling Study

Paediatric and Perinatal Epidemiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

ABSTRACT Background Individuals born preterm at very low birthweight (VLBW, < 1500 g) tend to attain a smaller adult body size compared with term‐born peers but less is known regarding specific composition characteristics. Objectives We aimed assess whether adults VLBW have beneficial characteristics, potentially mediating the association between birth and cardiometabolic disease. Sibling controls were used account for potential influence of shared genetic and/or lifestyle factors. Methods This cohort study featured 77 70 siblings. Dual‐energy X‐ray absorptiometry assessment took place mean age 29 years. Fat mass (FM) distribution was calculated by dividing appendicular truncal FM. Appendicular skeletal (ASM) measurements calculate two indices: Skeletal index (SMI, ASM divided height squared) ASM/BMI (ASM index). Data analysed linear mixed models. An exploratory analysis subdivided group gestational [small or appropriate (SGA, defined as 2 SD, AGA)]. Results Participants lighter (−4.7 kg, 95% CI −8.2, −1.2) shorter (−4.3 cm, −6.2, −2.4) than sibling peers. After controlling sex, age, maternal factors, they had lower limb/trunk fat ratios (−0.06, −0.11, −0.003), LBM (−2.02 −3.92, −0.12), (−1.22 −2.14, −0.30) (−0.05, −0.10, −0.004). FM SMI did not differ groups. In subgroup analysis, findings limited those + SGA. Conclusions had, on average, relative A more centralised distribution, well muscle mass, could mediate risk.

Язык: Английский

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Long-term health in individuals born preterm or with low birth weight: A cohort study

Pediatric Research, Год журнала: 2024, Номер unknown

Опубликована: Июль 4, 2024

Abstract Background To measure the association of prematurity and non-preterm low birth weight (LBW) with several long-term health outcomes. Methods We selected adult participants from Constances cohort. Associations between preterm (<37 weeks versus ≥37 weeks) outcomes were measured using modified Poisson regression adjustment for participant age parental history. used same modeling methods to LBW (i.e., <sex-specific 10th percentile) in born ≥ 37 weeks. tested an interaction exposures sex. Results Among 30,295 participants, (5.2%) was associated (RR[CI95]): obesity (1.25[1.08–1.46]), hypertriglyceridemia (1.23[1.07–1.42]), high LDL-cholesterol (1.16[1.05–1.28]), blood pressure (HBP) (1.22[1.08–1.36]), metabolic syndrome (1.35[1.06–1.71]), non-alcoholic fatty liver disease (1.26[1.08–1.47]), allergic atopic symptoms (1.06[1.01–1.12]), lack tertiary education (1.11[1.02–1.20]). Women had a significantly higher risk syndrome. In prediabetes/diabetes (1.30[1.12–1.52]), HBP (1.22[(1.12–1.33]) (1.13[1.07–1.20]), whereas (0.83[0.73–0.95]) abdominal (0.84[0.76–0.93]) reduced. Conclusion Preterm are both factors However, regarding excess fat storage, their effect seems be opposite direction. Impact statement is obesity, not. This study improves understanding common idea that it might depend on cause weight. These findings provide new insights into difficult distinction adverse effects

Язык: Английский

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Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children

Environment International, Год журнала: 2024, Номер 190, С. 108853 - 108853

Опубликована: Июнь 28, 2024

Studies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine associations between exposure during pregnancy early childhood with respiratory, cardiometabolic, neurodevelopmental outcomes in school-age children. We performed an Individual-Participant Data (IPD) meta-analysis involving 35,000 children from ten European birth cohorts across eight countries. For each participant, we calculated residential Normalized Difference Vegetation Index (NDVI) within a 300 m buffer linear distance (meters) prenatal life childhood. Multiple harmonized were selected: asthma wheezing, lung function, body mass index, diastolic systolic blood pressure, non-verbal intelligence, internalizing externalizing problems, ADHD symptoms. conducted two-stage IPD evaluated effect modification by socioeconomic status (SES) sex. Between-study heterogeneity was assessed via random-effects meta-regression. Residential surrounding childhood, not pregnancy, associated improved particularly higher FEV

Язык: Английский

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The effect of parental weight and genetics on the body mass index of very low birth weight infants as they reach school age

Deutsches Ärzteblatt international, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Prematurely born individuals are usually of low or normal weight in childhood; adulthood, however, their probability being overweight is twice that persons at full term. There not yet any way to predict the development premature babies. A polygenic BMI score (BMI = body-mass index), calculated from often very small individual effects more than 2 million genetic variants, was recently described for adults. We studied possible association this with course babies over time, infancy up age 10-14 years. 508 were included study. At 5-7 years, mean body 18.8 ± 3.3 kg. The difference between highest and lowest deciles 10-14, average 41.3 11.3 kg, had increased 9.2 In birth under 10th percentile (n 68), 19.2 kg (30.9 vs. 50.1 kg). significantly associated z-scores overall group subgroup growth-retarded children. Extreme values a strongly preterm infants as they develop into children aged 10-14. large effect size implies may aid counseling prematurely parents.

Язык: Английский

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Allele-specific methylation of SSTR4 associated with aging and cognitive functions in patients with schizophrenia

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0303038 - e0303038

Опубликована: Фев. 5, 2025

The co-occurrence of alcohol use disorder (AUD) and schizophrenia is prevalent, with a rate 33.7%. Previous research has suggested genetic epigenetic overlap between these two disorders. SSTR4 , member the somatostatin receptor family, implicated in various neurological psychiatric conditions, including cognitive function, AUD, schizophrenia. However, role genetic-epigenetic interactions involving patients remains unexplored. In this study, we conducted an integration publicly available datasets identified allele-specific methylation patterns SSTR4. Additionally, pinpointed several variants (rs17691954, rs11464356, rs3109190, rs145879288) that influence pace aging functions (rs705935) through their quantitative trait loci effects on CpG sites within .

Язык: Английский

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Growth Patterns in Preterm Children: Catch-Up Growth, Wasting, and Obesity Risk from the PERSIAN Birth Cohort

Опубликована: Янв. 1, 2025

Язык: Английский

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The associations of preterm birth and low birth weight with childhood growth curves between birth and 12 years: a SITAR-based longitudinal analysis

Annals of Human Biology, Год журнала: 2025, Номер 52(1)

Опубликована: Март 17, 2025

Aim To compare growth in length/height, weight, and BMI of preterm- term-born children, grouped by birth weight (BW) gestational age (GA).

Язык: Английский

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Short- and longer-term growth and development of fat mass in preterm infants

Seminars in Fetal and Neonatal Medicine, Год журнала: 2025, Номер unknown, С. 101636 - 101636

Опубликована: Апрель 1, 2025

Язык: Английский

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