Cancers,
Год журнала:
2024,
Номер
16(18), С. 3134 - 3134
Опубликована: Сен. 12, 2024
Stem
cells
are
critical
for
the
development
and
homeostasis
of
gastrointestinal
(GI)
tract.
Inflammatory
molecules
known
to
regulate
activity
stem
cells.
A
comprehensive
review
specifically
describing
role
inflammatory
in
regulation
within
GI
tract
cancers
(GICs)
is
not
available.
This
focuses
on
understanding
maintaining
We
further
discuss
how
conditions
contribute
transformation
into
tumor-initiating
also
describe
molecular
mechanisms
inflammation
cell-driven
progression
metastasis
GICs.
Furthermore,
we
report
studies
prognostic
value
cancer
clinical
trials
evaluating
their
therapeutic
utility.
provides
a
detailed
overview
implications
GI-related
malignancies.
Diabetes & Metabolism Journal,
Год журнала:
2024,
Номер
48(6), С. 1047 - 1055
Опубликована: Ноя. 22, 2024
The
consumption
of
ultra-processed
foods
(UPFs)
has
surged
globally,
raising
significant
public
health
concerns
due
to
their
associations
with
a
range
adverse
outcomes.
This
review
aims
elucidate
potential
impacts
UPF
intake
and
underscore
the
importance
considering
diet
quality
when
interpreting
study
findings.
group,
as
classified
by
Nova
system
based
on
extent
industrial
processing,
contains
numerous
individual
food
items
wide
spectrum
nutrient
profiles,
well
differential
reflected
effects.
given
may
misalign
processing
levels
so
that
can
be
nutritious
healthful
whereas
non-UPF
low
excess
which
lead
consequences.
current
argues
it
is
critical
focus
nutritional
content
role
within
overall
dietary
pattern
rather
than
only
level
processing.
Further
research
should
dissect
effects
investigate
ingredients
render
categorization,
understand
roles
metabolomics
gut
microbiome
in
mediating
modulating
consider
environmental
sustainability
studies.
Emphasizing
nutrient-dense
patterns
shall
remain
pivotal
strategy
for
promoting
preventing
chronic
diseases.
Marine Drugs,
Год журнала:
2024,
Номер
22(6), С. 258 - 258
Опубликована: Май 31, 2024
Microalgae
are
currently
considered
an
attractive
source
of
highly
valuable
metabolites
potentially
exploitable
as
anticancer
agents,
nutraceuticals
and
cosmeceuticals
for
bioenergy
purposes.
Their
ease
culturing
their
high
growth
rates
further
promote
use
raw
material
the
production
specialty
products.
In
present
paper,
we
focused
our
attention
on
specific
glycerol-based
lipid
compounds,
monoacylglycerols
(MAGs),
which
displayed
in
previous
studies
a
selective
cytotoxic
activity
against
haematological
U-937
colon
HCT-116
cancer
cell
lines.
Here,
performed
quali/quantitative
analysis
MAGs
total
fatty
acids
(FAs)
along
with
profiling
main
classes
panel
12
microalgal
species,
including
diatoms
dinoflagellates.
Our
results
highlight
inter-
intraspecific
variability
MAG
profile
selected
strains.
Among
them,
Skeletonema
marinoi
(strain
FE7)
has
emerged
most
promising
possible
biotechnological
MAGs.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 6, 2024
Abstract
A
crucial
early-life
developmental
phase
regulates
microbiome
settling
while
establishing
critical
and
long-lasting
immune
metabolic
processes.
During
this
period,
the
influence
of
select
components
maternal
diet
on
offspring
microbiota
health
remains
largely
unknown.
To
investigate
potential
transgenerational
impact
exposure
to
microbiota-disrupting
factors,
dams
were
subjected
prior
breeding
dietary
emulsifiers,
known
directly
perturb
microbiota.
Such
induced
alterations
in
which
associated
with
susceptibility
diet-induced
obesity
intestinal
inflammation.
These
detrimental
effects
entirely
prevented
by
normalization
through
cross-fostering
procedures.
Mechanistically,
emulsifier
induces
strong
offspring’s
impairment
goblet
cells-mediated
host-microbiota
communication
is
central
driving
observed
deleterious
effects.
conclude,
study
underscores
role
played
intake
agents
next
generation’s
microbiota,
long
lasting
consequences
for
health.
Cancers,
Год журнала:
2024,
Номер
16(18), С. 3134 - 3134
Опубликована: Сен. 12, 2024
Stem
cells
are
critical
for
the
development
and
homeostasis
of
gastrointestinal
(GI)
tract.
Inflammatory
molecules
known
to
regulate
activity
stem
cells.
A
comprehensive
review
specifically
describing
role
inflammatory
in
regulation
within
GI
tract
cancers
(GICs)
is
not
available.
This
focuses
on
understanding
maintaining
We
further
discuss
how
conditions
contribute
transformation
into
tumor-initiating
also
describe
molecular
mechanisms
inflammation
cell-driven
progression
metastasis
GICs.
Furthermore,
we
report
studies
prognostic
value
cancer
clinical
trials
evaluating
their
therapeutic
utility.
provides
a
detailed
overview
implications
GI-related
malignancies.