Different metazoan parasites, different transcriptomic responses, with new insights on parasitic castration by digenetic trematodes in the schistosome vector snail Biomphalaria glabrata

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Июнь 17, 2024

Abstract Background Gastropods of the genus Biomphalaria (Family Planorbidae) are exploited as vectors by Schistosoma mansoni , most common causative agent human intestinal schistosomiasis. Using improved genomic resources, overviews how responds to S. and other metazoan parasites can provide unique insights into reproductive, immune, systems invertebrate hosts, their responses parasite challenges. Results Illumina-based RNA-Seq, we compared iM line B. glabrata at 2, 8, 40 days post-infection (dpi) single infections with Echinostoma paraensei (both digenetic trematodes) or Daubaylia potomaca (a nematode planorbid snails). Responses were unexposed time-matched control snails. We observed: (1) each provoked a distinctive response predominance down-regulated snail genes all time points following exposure either trematode, up-regulated 8 especially 40dpi exposure; (2) At 2 8dpi several associated gametogenesis (particularly spermatogenesis) down-regulated. Regarding phenomenon trematode-mediated parasitic castration in molluscs, define for first complement host that targeted, early 2dpi when trematode larvae still small; (3) Differential gene expression snails infection 40dpi, shedding cercariae, was unexpectedly modest revealed down-regulation involved production egg mass proteins peptide processing; (4) surprisingly, D. up-regulation many reproduction-related noted be infection. Happening began succumb hypothesize this represents an unexpected form fecundity compensation. also document patterns families, including fibrinogen domain-containing (FReDs), C-type lectins, G-protein coupled receptors, biomphalysins, protease inhibitors. Conclusions Our study is relevant identifying reproduction targeted vector might amenable manipulation minimize ability serve schistosomes.

Язык: Английский

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Accelerating snail vector genomics

Infectious Diseases of Poverty, Год журнала: 2024, Номер 13(1)

Опубликована: Май 6, 2024

Abstract The three most important genera of snails for the transmission schistosomes are Bulinus , Biomphalaria and Oncomelania . Each these genera, found in two distantly related families, includes species that act as intermediate host one widespread schistosome infecting humans, Schistosoma haematobium, S. mansoni japonicum respectively. An step fight against schistosomiasis Asia has been taken with publication article “Chromosome-level genome assembly hupensis : snail ”, which means genomes all major including across continents, now available public domain. This first African vectors, namely sudanica Bi. pfeifferi truncatus well high-quality chromosome level assemblies South American glabrata Most importantly, wealth new genomic transcriptomic data is helping to establish specific molecular mechanisms underly compatibility between their schistosomes, although diverse complex, may help identify potential targets dictating parasite interactions can be utilised future control strategies. work on indeed studies other provide deep insights into genome, will stimulate research lead much needed interventions. Graphical

Язык: Английский

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Exploring the genome-wide transcriptomic responses of Bulinus truncatus to Schistosoma haematobium infection: An important host-parasite system involved in the transmission of human urogenital schistosomiasis

Molecular Immunology, Год журнала: 2024, Номер 175, С. 74 - 88

Опубликована: Сен. 21, 2024

Язык: Английский

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The genome sequence of the bloodfluke planorb, Biomphalaria glabrata (Say, 1818)

Wellcome Open Research, Год журнала: 2024, Номер 9, С. 435 - 435

Опубликована: Авг. 8, 2024

We present a genome assembly from an individual Biomphalaria glabrata (the bloodfluke planorb; Mollusca; Gastropoda; Planorbidae). The sequence spans 850.60 megabases. Most of the is scaffolded into 18 chromosomal pseudomolecules. mitochondrial has also been assembled and 13.67 kilobases in length. Gene annotation this on Ensembl identified 25,327 protein-coding genes.

Язык: Английский

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Genomic basis of schistosome resistance in a molluscan vector of human schistosomiasis

iScience, Год журнала: 2024, Номер 28(1), С. 111520 - 111520

Опубликована: Дек. 2, 2024

Freshwater snails are obligate intermediate hosts for the transmission of schistosomiasis, one world's most devastating parasitic diseases. To decipher mechanisms underlying snail resistance to schistosomes, recombinant inbred lines (RILs) were developed from two well-defined homozygous (iM line and iBS90)

Язык: Английский

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