The association between Clonorchis sinensis seropositivity and hepatocellular carcinoma in an endemic area: a study in Guangxi, China DOI Creative Commons
Qingli Yang, Xiwei Lu, Zhong‐Liao Fang

и другие.

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 25, 2025

Chronic infection with Clonorchis sinensis (C.sinensis) has been associated swith the development of intrahepatic cholangiocarcinoma (ICC); however, relationship between C.sinensis and hepatocellular carcinoma (HCC) remains uncertain. This study examined 120 patients liver cancer in clonorchiasis endemic area Hengzhou, Guangxi, China. The type cancer, differentiation grade according to Edmondson Steiner's classification, pathological characteristics HCC were determined through postoperative tissue biopsy. was detected by measuring serum specific IgG antibody, hepatitis B virus (HBV) detecting HBsAg HBV DNA tissues. rates control groups drawn from local general population based on previous surveys. association analyzed comparing differences two groups. Of evaluated, 98 (81.7%) had HCC, 21 (17.5%) ICC, 1 (0.8%) comorbidity HCC/ICC. Among patients, 24 (24.5%) solely infected HBV, 71 (72.4%) C. seropositive, 3 (3.1%) showed no evidence infection. seropositive are much higher than outpatient non-liver inpatients (χ2 = 141.92, p < 0.001), as well residents 82.61/21.38, 0.001). There significant type, grade, lesion composition tumor C.sinensis/HBV mono- co-infection (p > 0.05). C.sinensis-related 8 (8.2%) while 63 (64.3%) co-infected HBV. Infection a impact types 22.86, These findings indicate that still accounts for majority this region. In addition being most commonly related infection, may also be Co-infection enhance area. Not applicable.

Язык: Английский

The association between Clonorchis sinensis seropositivity and hepatocellular carcinoma in an endemic area: a study in Guangxi, China DOI Creative Commons
Qingli Yang, Xiwei Lu, Zhong‐Liao Fang

и другие.

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 25, 2025

Chronic infection with Clonorchis sinensis (C.sinensis) has been associated swith the development of intrahepatic cholangiocarcinoma (ICC); however, relationship between C.sinensis and hepatocellular carcinoma (HCC) remains uncertain. This study examined 120 patients liver cancer in clonorchiasis endemic area Hengzhou, Guangxi, China. The type cancer, differentiation grade according to Edmondson Steiner's classification, pathological characteristics HCC were determined through postoperative tissue biopsy. was detected by measuring serum specific IgG antibody, hepatitis B virus (HBV) detecting HBsAg HBV DNA tissues. rates control groups drawn from local general population based on previous surveys. association analyzed comparing differences two groups. Of evaluated, 98 (81.7%) had HCC, 21 (17.5%) ICC, 1 (0.8%) comorbidity HCC/ICC. Among patients, 24 (24.5%) solely infected HBV, 71 (72.4%) C. seropositive, 3 (3.1%) showed no evidence infection. seropositive are much higher than outpatient non-liver inpatients (χ2 = 141.92, p < 0.001), as well residents 82.61/21.38, 0.001). There significant type, grade, lesion composition tumor C.sinensis/HBV mono- co-infection (p > 0.05). C.sinensis-related 8 (8.2%) while 63 (64.3%) co-infected HBV. Infection a impact types 22.86, These findings indicate that still accounts for majority this region. In addition being most commonly related infection, may also be Co-infection enhance area. Not applicable.

Язык: Английский

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