Abstract
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
that
characterized
by
impairments
in
social
interactions
and
communication,
restricted
interests
repetitive
behaviors.
Several
studies
report
high
prevalence
of
gastrointestinal
(GI)
symptoms
autistic
individuals.
Cumulative
evidence
reveals
the
gut
microbiota
its
metabolites
(especially
short-chain
fatty
acids,
SCFAs)
play
an
important
role
GI
disorders
pathogenesis
ASD.
However,
composition
association
with
fecal
SCFAs
children
remain
largely
unknown.
In
present
study,
we
sequenced
bacterial
16S
rRNA
gene,
detected
SCFAs,
assessed
analyzed
relationship
between
microbiome
neurotypical
The
results
showed
compositions
were
altered
ASD
We
found
lower
levels
acetic
acid
butyrate
higher
level
valeric
subjects.
identified
decreased
abundances
key
butyrate-producing
taxa
(
Ruminococcaceae,
Eubacterium,
Lachnospiraceae
Erysipelotrichaceae
)
increased
abundance
associated
bacteria
Acidobacteria
among
Constipation
was
only
study.
also
enriched
Fusobacterium
,
Barnesiella,
Coprobacter
acid-associated
Actinomycetaceae
reduced
constipated
It
suggested
contributes
to
constipation
autism.
Modulating
microbiota,
especially
bacteria,
could
be
promising
strategy
search
for
alternatives
treatment
autism
disorder.
The
qualified
presumption
of
safety
(QPS)
approach
was
developed
to
provide
a
regularly
updated
generic
pre-evaluation
the
biological
agents,
intended
for
addition
food
or
feed,
support
work
EFSA's
Scientific
Panels.
It
is
based
on
an
assessment
published
data
each
agent,
with
respect
its
taxonomic
identity,
body
knowledge,
concerns
and
antimicrobial
resistance.
Safety
identified
unit
(TU)
are,
where
possible,
confirmed
at
strain
product
level,
reflected
by
'qualifications'.
In
period
covered
this
statement,
no
new
information
found
that
would
change
status
previously
recommended
QPS
TUs.
Of
36
microorganisms
notified
EFSA
between
April
September
2020,
33
were
excluded;
seven
filamentous
fungi
(including
Aureobasidium
pullulans
recent
insights),
one
Clostridium
butyricum,
Enterococcus
faecium,
three
Escherichia
coli,
Streptomyces
spp.
20
TUs
had
been
evaluated.
Three
evaluated;
Methylorubrum
extorquens
Mycobacterium
aurum
first
time
Bacillus
circulans
re-assessed
because
update
requested
in
relation
mandate.
M.
are
not
due
lack
knowledge
use
feed
chain
aurum,
uncertainty
concerning
pathogenicity
potential.
B.
qualifications
'production
purposes
only'
'absence
cytotoxic
activity'.
Frontiers in Cellular Neuroscience,
Год журнала:
2017,
Номер
11
Опубликована: Апрель 28, 2017
Gastrointestinal
(GI)
symptoms
are
a
common
comorbidity
in
patients
with
autism
spectrum
disorder
(ASD),
but
the
underlying
mechanisms
unknown.
Many
studies
have
shown
alterations
composition
of
fecal
flora
and
metabolic
products
gut
microbiome
ASD.
The
microbiota
influences
brain
development
behaviors
through
neuroendocrine,
neuroimmune
autonomic
nervous
systems.
In
addition,
an
abnormal
is
associated
several
diseases,
such
as
inflammatory
bowel
disease
(IBD),
ASD
mood
disorders.
Here,
we
review
bidirectional
interactions
between
central
system
gastrointestinal
tract
(brain-gut
axis)
role
Microbiome-mediated
therapies
might
be
safe
effective
treatment
for
Nutrients,
Год журнала:
2019,
Номер
11(3), С. 521 - 521
Опубликована: Фев. 28, 2019
In
recent
years,
there
has
been
an
emerging
interest
in
the
possible
role
of
gut
microbiota
as
a
co-factor
development
autism
spectrum
disorders
(ASDs),
many
studies
have
highlighted
bidirectional
communication
between
and
brain
(the
so-called
"gut-brain
axis").
Accumulating
evidence
shown
link
alterations
composition
both
gastrointestinal
neurobehavioural
symptoms
children
with
ASD.
The
aim
this
narrative
review
was
to
analyse
current
knowledge
about
dysbiosis
(GI)
ASD
assess
for
probiotics
other
non-pharmacological
approaches
treatment
Analysis
literature
showed
that
widely
demonstrated;
however,
is
no
single
distinctive
profile
people
Gut
could
contribute
low-grade
systemic
inflammatory
state
reported
patients
GI
comorbidities.
administration
(mostly
mixture
Abstract
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
that
characterized
by
impairments
in
social
interactions
and
communication,
restricted
interests
repetitive
behaviors.
Several
studies
report
high
prevalence
of
gastrointestinal
(GI)
symptoms
autistic
individuals.
Cumulative
evidence
reveals
the
gut
microbiota
its
metabolites
(especially
short-chain
fatty
acids,
SCFAs)
play
an
important
role
GI
disorders
pathogenesis
ASD.
However,
composition
association
with
fecal
SCFAs
children
remain
largely
unknown.
In
present
study,
we
sequenced
bacterial
16S
rRNA
gene,
detected
SCFAs,
assessed
analyzed
relationship
between
microbiome
neurotypical
The
results
showed
compositions
were
altered
ASD
We
found
lower
levels
acetic
acid
butyrate
higher
level
valeric
subjects.
identified
decreased
abundances
key
butyrate-producing
taxa
(
Ruminococcaceae,
Eubacterium,
Lachnospiraceae
Erysipelotrichaceae
)
increased
abundance
associated
bacteria
Acidobacteria
among
Constipation
was
only
study.
also
enriched
Fusobacterium
,
Barnesiella,
Coprobacter
acid-associated
Actinomycetaceae
reduced
constipated
It
suggested
contributes
to
constipation
autism.
Modulating
microbiota,
especially
bacteria,
could
be
promising
strategy
search
for
alternatives
treatment
autism
disorder.
