Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice DOI Creative Commons
Deyana Ivanova, Xiaofeng Li, Caitlin McIntyre

и другие.

Endocrinology, Год журнала: 2021, Номер 162(12)

Опубликована: Окт. 7, 2021

Abstract Psychosocial stress disrupts reproduction and interferes with pulsatile LH secretion. The posterodorsal medial amygdala (MePD) is an upstream modulator of the reproductive axis stress. Corticotropin-releasing factor type 2 receptors (CRFR2s) are activated in presence psychosocial together increased expression CRFR2 ligand Urocortin3 (Ucn3) MePD rodents. We investigate whether Ucn3 signalling involved mediating suppressive effect on pulsatility. First, we administered into monitored pulses ovariectomized mice. Next, delivered Astressin2B, a selective antagonist, intra-MePD predator odor, 2,4,5-trimethylthiazole (TMT) examined pulses. Subsequently, virally infected Ucn3-cre-tdTomato mice inhibitory designer receptor exclusively by drugs (DREADDs) targeting neurons while exposing to TMT or restraint pulsatility as well corticosterone release. Administration dose-dependently inhibited administration Astressin2B blocked Additionally, DREADDs inhibition stress-induced These results demonstrate for first time that mediate suppression GnRH pulse generator plays role modulating hypothalamic-pituitary-gonadal hypothalamic-pituitary-adrenal axes, this brain locus may represent nodal center interaction between axes.

Язык: Английский

Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion DOI
Robert L. Goodman, Allan E. Herbison, Michael N. Lehman

и другие.

Journal of Neuroendocrinology, Год журнала: 2022, Номер 34(5)

Опубликована: Янв. 19, 2022

Abstract The concept that different systems control episodic and surge secretion of gonadotropin‐releasing hormone (GnRH) was well established by the time GnRH identified formed framework for studies physiological roles GnRH, later kisspeptin. Here, we focus on recent identifying neural mechanisms underlying these two modes secretion, with an emphasis their core components. There is now compelling data kisspeptin neurons in arcuate nucleus also contain neurokinin B (NKB) dynorphin (i.e., KNDy cells) projections to dendrons constitute pulse generator mice rats. strong evidence a similar role sheep goats, weaker monkeys humans. However, whether act and/or soma dendrites are found mediobasal hypothalamus (MBH) species remains unclear. components GnRH/luteinising consist endocrine signal initiates process trigger drives during surge. In all spontaneous ovulators, rise estradiol from maturing follicle(s), site estrogen positive feedback being rostral periventricular rodents MBH primates. considerable variations trigger, three major classes. First, reflex this initiated coitus carried or vascular pathways. Second, rodents, there day originates suprachiasmatic activates dendrites. Finally, nitric oxide‐producing ventromedial nucleus, appear participate driving release

Язык: Английский

Процитировано

107
Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells as integrators of diverse internal and external cues: evidence from viral-based monosynaptic tract-tracing in mice DOI Creative Commons
Aleisha M. Moore, Lique M. Coolen, Michael N. Lehman

и другие.

Scientific Reports, Год журнала: 2019, Номер 9(1)

Опубликована: Окт. 14, 2019

Neurons in the hypothalamic arcuate nucleus (ARC) that co-express kisspeptin, neurokinin B and dynorphin (KNDy cells) are essential for mammalian reproduction as key regulators of gonadotropin-releasing hormone (GnRH) secretion. Although multiple endogenous exogenous signals act indirectly via KNDy neurons to regulate GnRH, identity upstream provide synaptic input this subpopulation is unclear. We used rabies-mediated tract-tracing transgenic Kiss1-Cre mice combined with whole-brain optical clearing multiple-label immunofluorescence create a comprehensive quantitative brain-wide map providing monosynaptic cells, well identify estrogen receptor content peptidergic phenotype afferents. Over 90% originated from nuclei both male female mice. The greatest arose non-KNDy ARC neurons, including proopiomelanocortin-expressing cells. Significant female-dominant sex differences afferent were detected estrogen-sensitive critical reproductive endocrine function sexual behavior mice, indicating cells may unique site coordination sex-specific gonadotropin release. These data insight into structural framework underlying ability integrate environmental important regulation function.

Язык: Английский

Процитировано

70
Somato‐dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation DOI
Colin H. Brown, Mike Ludwig, Jeffrey G. Tasker

и другие.

Journal of Neuroendocrinology, Год журнала: 2020, Номер 32(6)

Опубликована: Апрель 17, 2020

Somato-dendritic secretion was first demonstrated over 30 years ago. However, although its existence has become widely accepted, the function of somato-dendritic is still not completely understood. Hypothalamic magnocellular neurosecretory cells were among neuronal phenotypes in which and are neurones for functions best characterised. These secrete neuropeptides, vasopressin oxytocin, an orthograde manner from their axons posterior pituitary gland into blood circulation to regulate body fluid balance reproductive physiology. Retrograde oxytocin modulates activity they secreted, as well neighbouring populations neurones, provide intra- inter-population signals that coordinate endocrine autonomic responses control peripheral have also been proposed act hormone-like brain. There some evidence beyond local environment where there no vasopressin- or oxytocin-containing but, date, conclusive for, against, signalling throughout brain, it difficult imagine levels found brain could be underpinned by release relatively sparse axon terminal fields. The generation data resolve this issue remains a priority field.

Язык: Английский

Процитировано

61
Loss-of-function variants in SEMA3F and PLXNA3 encoding semaphorin-3F and its receptor plexin-A3 respectively cause idiopathic hypogonadotropic hypogonadism DOI Creative Commons
Leman Damla Kotan, Gaëtan Ternier, Aydilek Dağdeviren Çakır

и другие.

Genetics in Medicine, Год журнала: 2021, Номер 23(6), С. 1008 - 1016

Опубликована: Янв. 25, 2021

Язык: Английский

Процитировано

51
Prenatal Androgen Exposure Alters KNDy Neurons and Their Afferent Network in a Model of Polycystic Ovarian Syndrome DOI Open Access
Aleisha M. Moore,

Dayanara B Lohr,

Lique M. Coolen

и другие.

Endocrinology, Год журнала: 2021, Номер 162(11)

Опубликована: Авг. 4, 2021

Abstract Polycystic ovarian syndrome (PCOS), the most common endocrinopathy affecting women worldwide, is characterized by elevated luteinizing hormone (LH) pulse frequency due to impaired suppression of gonadotrophin-releasing (GnRH) release steroid negative feedback. Although neurons that co-express kisspeptin, neurokinin B, and dynorphin (KNDy cells) were recently defined as GnRH/LH generator, little understood about their role in pathogenesis PCOS. We used a prenatal androgen-treated (PNA) mouse model PCOS determine whether changes KNDy or afferent network underlie altered First, we identified androgen receptor gene expression cells PNA mice, whereas progesterone was significantly reduced, suggesting androgens disrupt feedback via direct actions upon cells. Second, discovered GABAergic glutamatergic synaptic input reduced mice. Retrograde monosynaptic tract-tracing revealed dramatic reduction originates from sexually dimorphic afferents preoptic area, anteroventral periventricular nucleus, anterior hypothalamic area lateral hypothalamus. These results reveal 2 sites neuronal alterations potentially responsible for defects PCOS: within neurons, inputs hormone-responsive regions. How each these contribute neuroendocrine phenotype seen PCOS, specific sets upstream process, remains be determined.

Язык: Английский

Процитировано

51
Neuroendocrine interactions of the stress and reproductive axes DOI Creative Commons
Chayarndorn Phumsatitpong,

Elizabeth R. Wagenmaker,

Suzanne M. Moenter

и другие.

Frontiers in Neuroendocrinology, Год журнала: 2021, Номер 63, С. 100928 - 100928

Опубликована: Июнь 24, 2021

Язык: Английский

Процитировано

44
The impact of inflammatory stress on hypothalamic kisspeptin neurons: Mechanisms underlying inflammation-associated infertility in humans and domestic animals DOI Creative Commons
Fumie Magata, Hiroko Tsukamura, Fuko Matsuda

и другие.

Peptides, Год журнала: 2023, Номер 162, С. 170958 - 170958

Опубликована: Янв. 20, 2023

Язык: Английский

Процитировано

18
Can kisspeptin be a new treatment for sexual dysfunction? DOI

Julie Bakker

Trends in Endocrinology and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1
Neural and endocrine mechanisms underlying stress-induced suppression of pulsatile LH secretion DOI Creative Commons
Richard B. McCosh, Kellie M. Breen, Alexander S. Kauffman

и другие.

Molecular and Cellular Endocrinology, Год журнала: 2019, Номер 498, С. 110579 - 110579

Опубликована: Сен. 12, 2019

Язык: Английский

Процитировано

47
KNDy neurones and GnRH/LH pulse generation: Current understanding and future aspects DOI
Yoshihisa Uenoyama, Hiroko Tsukamura

Journal of Neuroendocrinology, Год журнала: 2023, Номер 35(9)

Опубликована: Май 2, 2023

Abstract Uncovering the central mechanism underlying mammalian reproduction is warranted to develop new therapeutic approaches for reproductive disorders in humans and domestic animals. The present study focused on role of arcuate kisspeptin neurones (also known as KNDy neurones) an intrinsic gonadotropin‐releasing hormone (GnRH) pulse generator, which plays a fundamental via stimulation pituitary gonadotropin synthesis release thereby gametogenesis steroidogenesis gonads mammals. We also discuss that inhibits pulsatile GnRH/gonadotropin under negative energy balance, considering often occur during malnutrition livestock.

Язык: Английский

Процитировано

15