Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(20), С. 7609 - 7609

Опубликована: Окт. 15, 2020

Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence stroke highest in developing countries, with ischemic being most common type. Considerable progress has been made our understanding pathophysiology underlying mechanisms insult. therapy primarily focuses on restoring blood flow brain treating stroke-induced neurological damage. Lack success recent clinical trials led significant refinement animal models, focus-driven study design use new technologies research. Simultaneously, despite management, post-stroke care exerts substantial impact families, healthcare system economy. Improvements pre-clinical are likely underpin successful treatment, recovery, rehabilitation prevention. In this review, we focus stroke, advances identification therapeutic targets trends

Язык: Английский

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Immersive Virtual Reality in Post-Stroke Rehabilitation: A Systematic Review

Sensors, Год журнала: 2023, Номер 23(3), С. 1712 - 1712

Опубликована: Фев. 3, 2023

In recent years, next to conventional rehabilitation’s techniques, new technologies have been applied in stroke rehabilitation. this context, fully immersive virtual reality (FIVR) has showed interesting results thanks the level of immersion subject illusional world, with feeling being a real part environment. This study aims investigate efficacy FIVR PubMed, Web Science and Scopus were screened up November 2022 identify eligible randomized controlled trials (RCTs). Out 4623, we included 12 RCTs involving post-acute chronic survivors, total 350 patients (234 men 115 women; mean age 58.36 years). High heterogeneity outcomes considered, that provides additional benefits, comparison standard particular, an improvement upper limb dexterity, gait performance dynamic balance, influencing patient independence. Therefore, represents adaptable, multi-faceted rehabilitation tool can be considered post-stroke rehabilitation, improving compliance treatment increasing functioning quality life survivors.

Язык: Английский

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Guidance to best tools and practices for systematic reviews

Systematic Reviews, Год журнала: 2023, Номер 12(1)

Опубликована: Июнь 8, 2023

Abstract Data continue to accumulate indicating that many systematic reviews are methodologically flawed, biased, redundant, or uninformative. Some improvements have occurred in recent years based on empirical methods research and standardization of appraisal tools; however, authors do not routinely consistently apply these updated methods. In addition, guideline developers, peer reviewers, journal editors often disregard current methodological standards. Although extensively acknowledged explored the literature, most clinicians seem unaware issues may automatically accept evidence syntheses (and clinical practice guidelines their conclusions) as trustworthy. A plethora tools recommended for development evaluation syntheses. It is important understand what intended cannot do) how they can be utilized. Our objective distill this sprawling information into a format understandable readily accessible authors, editors. doing so, we aim promote appreciation understanding demanding science synthesis among stakeholders. We focus well-documented deficiencies key components elucidate rationale The constructs underlying developed assess reporting, risk bias, quality distinguished from those involved determining overall certainty body evidence. Another distinction made between used by develop opposed ultimately judge work. Exemplar practices described, complemented novel pragmatic strategies improve latter include preferred terminology scheme characterize types organize best resources Concise Guide widely adopted adapted routine implementation journals. Appropriate, informed use encouraged, but caution against superficial application emphasize endorsement does substitute in-depth training. By highlighting with rationale, hope guidance will inspire further evolution advance field.

Язык: Английский

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Virtual Reality in Neurorehabilitation: An Umbrella Review of Meta-Analyses

Journal of Clinical Medicine, Год журнала: 2021, Номер 10(7), С. 1478 - 1478

Опубликована: Апрель 2, 2021

Neurological disorders are a leading cause of death and disability worldwide. Can virtual reality (VR) based intervention, novel technology-driven change paradigm in rehabilitation, reduce impairments, activity limitations, participation restrictions? This question is directly addressed here for the first time using an umbrella review that assessed effectiveness quality evidence VR interventions physical cognitive rehabilitation patients with stroke, traumatic brain injury cerebral palsy, identified factors can enhance outcomes safety concerns. Forty-one meta-analyses were included. The data synthesis found mostly low- or very low-quality supports interventions. Only limited number comparisons rated as having moderate high evidence, but overall, results highlight potential benefits improving ambulation function children mobility, balance, upper limb function, body structure/function people acquired injury. Customization systems one important factor linked improved outcomes. Most studies do not address concerns, only nine reviews reported adverse effects. provide critical recommendations design implementation future programs, trials systematic reviews, including need randomized controlled to test principles mechanisms, primary meta-analyses, order formulate evidence-based guidelines designing VR-based

Язык: Английский

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Post-Stroke Cognitive Impairments and Responsiveness to Motor Rehabilitation: A Review

Current Physical Medicine and Rehabilitation Reports, Год журнала: 2020, Номер 8(4), С. 461 - 468

Опубликована: Сен. 10, 2020

Язык: Английский

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Dynamic Stability and Trunk Control Improvements Following Robotic Balance and Core Stability Training in Chronic Stroke Survivors: A Pilot Study

Frontiers in Neurology, Год журнала: 2020, Номер 11

Опубликована: Июнь 17, 2020

Stroke survivors show greater postural oscillations and altered muscular activation compared to healthy control. This results in difficulties walking standing, an increased risk of falls. A proper control the trunk is related a stable walk lower falling risk; this extent, rehabilitative protocols are currently working on core stability. The main objective work was evaluate effectiveness balance training performed with hunova, new robotic device designed for evaluation stability, improving recovery chronic stroke patients traditional physical therapy program. Thirty patients, randomly divided two groups, either underwent protocol, or robot-based Each patient assessed before after rehabilitation at three-months follow-up clinical exercises focused static dynamic balance, stability Results from scales showed improvement both groups Robot-based indices analysis indicated that experimental group improvements proprioceptive control, reactive unstable conditions, group, showing improved reduced compensatory strategies end training. Moreover, had retention obtained three months follow up. These support idea hunova promising tool rehabilitation.

Язык: Английский

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Ultra‐Wide Range Pressure Sensor Based on a Microstructured Conductive Nanocomposite for Wearable Workout Monitoring

Advanced Healthcare Materials, Год журнала: 2021, Номер 10(9)

Опубликована: Март 10, 2021

Conventional flexible pressure sensors are not suitable for high-pressure applications due to their low saturation pressure. In this study, an ultra-wide range sensor is designed based on the optimized microstructure of polyimide/carbon nanotubes (PI/CNT) nanocomposite film. The sensing expanded by adopting polyimide (PI) with a high elastic modulus as matrix material and its sensitivity improved through functional film tip-flattened microdome arrays. As result, can measure wide (≈ 0-3000 kPa) possesses ≈ 5.66 × 10-3 -0.23 kPa-1 reliability durability up 1000 cycles. proposed integrated into hand foot monitoring systems workout monitoring. representative values distribution in hands feet during powerlifting acquired analyzed Pearson's correlation coefficient (PCC). results suggest that provide useful real-time information healthcare sports performance

Язык: Английский

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The quality of systematic reviews/meta‐analyses published in the field of bariatrics: A cross‐sectional systematic survey using AMSTAR 2 and ROBIS

Obesity Reviews, Год журнала: 2020, Номер 21(5)

Опубликована: Янв. 29, 2020

Summary High‐quality systematic reviews (SR) and meta‐analyses (MA) are considered to be reliable sources of information. This study aims assess the quality studies published as SR or MA in field bariatrics 2016 2017. We identified by searching electronic databases (MEDLINE, Embase, Cochrane Database Systematic Reviews). Eligible were those SR/MA title/abstract, which aimed any outcome patients with morbid obesity undergoing scheduled undergo bariatric surgery. Two authors independently reviewed all titles abstracts, assessed full texts potentially eligible studies, included studies. Any discrepancies resolved third reviewer. evaluated risk bias each using AMSTAR 2 checklist ROBIS tool, respectively. Seventy‐eight 4236 references met inclusion criteria for their quality/risk bias. The methodological 99% papers was classified “critically low.” A total 6% at low bias, 78% being high 2017 is highly unsatisfactory.

Язык: Английский

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AMSTAR 2 appraisal of systematic reviews and meta-analyses in the field of heart failure from high-impact journals

Systematic Reviews, Год журнала: 2022, Номер 11(1)

Опубликована: Июль 23, 2022

The Measurement Tool to Assess systematic Reviews (AMSTAR) 2 is a critical appraisal tool for reviews (SRs) and meta-analyses (MAs) of interventions. We aimed perform the first AMSTAR 2-based quality assessment heart failure-related studies.

Язык: Английский

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Effect of Tai Chi Exercise on Balance Function of Stroke Patients: A Meta-Analysis

Medical science monitor basic research/Medical science monitor. Basic research, Год журнала: 2018, Номер 24, С. 210 - 215

Опубликована: Дек. 3, 2018

BACKGROUND:Tai Chi is an ancient form of physical activity that has been shown to improve cardiovascular function, but date there had no comprehensive systematic review on the effect Tai exercise balance function patients with stroke. This study evaluated in stroke patients. MATERIAL AND METHODS:PubMed, Cochrane library, and China National Knowledge Information databases Wan Fang medical network were searched collect articles. The random-effects model was used assess RESULTS:Six studies chosen perform meta-analysis according inclusion exclusion criteria. There significant improvements Berg Balance Scale score (MD=4.823, 95% CI: 2.138–7.508), standing fall rates (RR=0.300, 95%CI: 0.120–0.770), functional reach test dynamic gait index intervention group compared control group. However, short performance battery for (SPBB) showed did not significantly ability (MD=0.293, –0.099~0.685). CONCLUSIONS:Tai might have a impact improving efficiency by increasing BBS reducing rate.

Язык: Английский

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