Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression

CNS Neuroscience & Therapeutics, Год журнала: 2023, Номер 30(4)

Опубликована: Ноя. 6, 2023

Abstract Background The comorbidity between diabetes mellitus and depression was revealed, increased the prevalence of depressive disorder, which ranked 13th in leading causes disability‐adjusted life‐years. Insulin resistance, is common mellitus, has risk symptoms both humans animals. However, mechanisms behind are multi‐factorial complicated. There still no causal chain to explain exactly. Moreover, Selective serotonin reuptake inhibitors, insulin metformin, recommended for treating mellitus‐induced depression, were found be a factor some complications diabetes. Aims Given these problems, many researchers made remarkable efforts analyze complicating from different aspects, including stress Hypothalamic–Pituitary–Adrenal axis, neurological system, oxidative stress, inflammation. Drug therapy, such as Hydrogen Sulfide, Cannabidiol, Ascorbic Acid Hesperidin, conducive alleviating depression. Here, we reviewed exact pathophysiology underlying disorder drug therapy. Methods review refers available literature PubMed Web Science, searching critical terms related Results In this review, that brain structure function, neurogenesis, brain‐derived neurotrophic glucose lipid metabolism involved comorbidity. Obesity might lead through reduced adiponectin leptin resistin. addition, therapy displayed could expand region potential Conclusions summarizes It also overviews with anti‐diabetic anti‐depressant effects.

Язык: Английский

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Serum levels of interleukin-33 and mesencephalic astrocyte derived neurotrophic factors in patients with major depressive disorder: a cross-sectional comparative design

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 12, 2024

Abstract Background Major depressive disorder (MDD) is a debilitating health condition that has significant morbidity and mortality rates. Depression can be caused due to social, biological, environmental, psychological, genetic factors. A few biological processes have been proposed as the pathophysiological pathways of depression. Neurotrophic factors inflammatory cytokines linked Thus, we aimed investigate serum interleukin-33 (IL-33) mesencephalic astrocyte-derived neurotrophic factor (MANF) in MDD patients corresponding healthy controls (HCs). Method This study involved inclusion 129 125 HCs matched by sex age. psychiatrist evaluated participants following DSM-5 criteria. The severity illness was assessed utilizing Hamilton Rating Scale (Ham-D). concentrations IL-33 MANF were measured using enzyme-linked immunosorbent assay (ELISA) kits. Results mean levels decreased (159.12 ± 6.07 pg/ml vs. 180.60 8.64 pg/ml, p = 0.042), increased (5.40 0.19 ng/ml 4.46 0.21 ng/ml, 0.001) when compared HCs. Conclusions current proposes lower higher are associated with progression depression severity. These biomarkers could used risk assessment tools for MDD. We recommend more investigation, including population, determine precise function

Язык: Английский

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Association of reduced serum EGF and leptin levels with the pathophysiology of major depressive disorder: A case-control study

PLoS ONE, Год журнала: 2023, Номер 18(7), С. e0288159 - e0288159

Опубликована: Июль 3, 2023

Major depressive disorder (MDD) is a heterogeneous mental having very diverse course and causing significant changes in daily life. Though the exact pathophysiology of depression still not known, an alteration serum levels cytokines neurotrophic factors was seen MDD subjects. In this study, we compared 'pro-inflammatory cytokine leptin factor EGF' healthy controls (HCs) patients. To make findings more accurate, eventually looked for correlation between altered EGF severity disease condition.For case-control about 205 patients were enrolled from Department Psychiatry, Bangabandhu Sheikh Mujib Medical University, Dhaka, 195 HCs various parts Dhaka. The DSM-5 utilized to evaluate diagnose participants. HAM-D 17 scale used measure depression. After collecting blood samples, they centrifuged produce clear samples. These samples analyzed using enzyme-linked immunosorbent assay (ELISA) kits levels.We observed lowered (524.70 ± 27.25 pg/ml vs. 672.52 49.64 pg/ml, p = 0.009), score elevated (17.17 0.56 2.49 0.43, p<0.001). But no established However, differences case (p 0.231).Our study suggest that reduced have impact on pathogenesis as per our investigation, correlated with levels. Our regarding association would help use risk indicator We further clinical investigations determine precise function

Язык: Английский

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Higher serum nerve growth factor levels are associated with major depressive disorder pathophysiology: a case–control study

Journal of International Medical Research, Год журнала: 2023, Номер 51(4)

Опубликована: Апрель 1, 2023

There is a lack of established biological, psychological, social, and digital markers for the prediction, identification, stratification patients with major depressive disorder (MDD). We therefore aimed to evaluate serum nerve growth factor (NGF) in MDD patients.In this case-control study, we recruited age- sex-matched healthy controls (HCs). A qualified psychiatrist evaluated study participants according Diagnostic Statistical Manual Mental Disorders, fifth edition. Serum NGF levels were analyzed using commercially available enzyme-linked immunosorbent assay kit.We data from 106 88 HCs. Mean concentrations significantly higher (104.70 ± 6.43 pg/mL) than HCs (72.09 7.69 pg/mL). Receiver operating characteristic curve analysis revealed good diagnostic performance MDD.Higher might be involved pathophysiology, altered may an early warning sign depression. The present findings will aid development new improved therapies patients. Further interventional studies are recommended explore underlying mechanisms, risk factors, disease course, treatment responses MDD.

Язык: Английский

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Evaluation of serum interleukin-12 and interleukin-4 as potential biomarkers for the diagnosis of major depressive disorder

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 18, 2024

Abstract Recently, scientists have focused on pro-inflammatory cytokines and immunological dysregulation in major depressive disorder (MDD). Some research suggests cytokines' role MDD development, whereas anti-inflammatory studies are sparse. There is no systematic investigation of Bangladeshi patients' pro- cytokines. This study examines the blood levels IL-12 IL-4 patients healthy controls (HCs) to determine diagnostic accuracy these identify from those without MDD. A total 110 people with department psychiatry a teaching hospital Dhaka 107 HCs participated this case–control study. Depression illness severity were gauged using DSM-5 criteria Ham-D scores. Commercially marketed ELISA kits used accordance manufacturer guidelines measure peripheral blood, allowing comparison patient control groups. In HCs, (5333.00 ± 307.40 pg/ml) showed noticeably higher than (2331.00 207.40 pg/ml). The increased positively correlated scores (male: r = 0.351, p < 0.050; female: 0.389, 0.050), suggesting possible relationship disease progression. Additionally, compared (272.81 23.94 pg/ml), had significantly (876.35 66.73 (p 0.001). Also, there was positive correlation between serum 0.361, 0.398, 0.050). Therefore, we observed their association depression. results demonstrate possibility as distinct markers capable differentiating possibly acting susceptibility. To ascertain effectiveness two cytokines, more necessary.

Язык: Английский

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Evaluation of serum interleukin‐1 receptor antagonist levels in major depressive disorder: A case‐control study

Health Science Reports, Год журнала: 2023, Номер 6(4)

Опубликована: Март 29, 2023

Abstract Background and Aims Major depressive disorder (MDD) is characterized by the occurrence of one or more episodes lasting a minimum 2 weeks marked persistently low mood lack enjoyment in daily activities. The diagnosis MDD not possible well‐established laboratory test biomarker. A wide range potential biomarkers for depression have been proposed many studies, but none them has adequately described correlation between depression. purpose this study was to evaluate serum interleukin‐1 receptor antagonist (IL‐1RA) levels as an early risk factor. Methods present case‐control included 88 participants. Among them, 44 patients enrolled from psychiatry department public hospital Dhaka, Bangladesh, age‐ sex‐matched healthy controls (HCs) various sites Dhaka city. qualified psychiatrist evaluated cases HCs based on fifth edition diagnostic statistical manual mental disorders (DSM‐5). Hamilton (Ham‐D) rating scale employed intensity An enzyme‐linked immunosorbent assay kit (Boster Bio, USA) used determine IL‐1RA concentrations. Results We observed no alteration concentration comparison (292.81 ± 24.81 288 24.87 pg/mL; p > 0.05). patients, we found noteworthy association severity levels. Conclusion findings imply that may be identified promising biomarker assessment However, its neuroprotective role taken into consideration understanding pathophysiology MDD.

Язык: Английский

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Adipocytokines levels as potential biomarkers for discriminating patients with a diagnosis of depressive disorder from healthy controls

Journal of Psychiatric Research, Год журнала: 2024, Номер 171, С. 163 - 170

Опубликована: Янв. 20, 2024

Язык: Английский

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Elevated Serum IL-2 Levels are Associated With Major Depressive Disorder: A Case-Control Study

Clinical Pathology, Год журнала: 2023, Номер 16

Опубликована: Янв. 1, 2023

Numerous earlier studies have stated an association between major depressive disorder (MDD) and altered expression of inflammatory process. However, it still needs to determine whether the alteration cytokines is causative factor or a consequence this disorder. Therefore, we attempted evaluate role pro-inflammatory cytokine IL-2 in pathophysiology depression.We collected blood samples from 111 MDD patients 112 healthy controls (HCs) matched by age sex. Diagnostic statistical manual mental disorders (DSM-5) score was used assess study participants. We determined severity depression using Hamilton Depression (Ham-D) rating scale. assayed serum levels Enzyme-Linked Immunosorbent Assay (ELISA) kit.Elevated were detected than HCs (29.79 ± 6.18 12.77 4.84 pg/ml, P < 0.05). observed higher level female compared (31.98 8.34 7.76 0.36 witnessed sex-specific correlation Ham-D found that females with scores had levels. Moreover, ROC curve represented good diagnostic performance as biomarker sensitivity specificity values 83.7% 80.4%, respectively.The current findings indicate elevated are associated MDD. This may be cause triggering result activated process during depression. recommend further interventional research clarify actual reasons for these patients.

Язык: Английский

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Altered serum TNF-α and MCP-4 levels are associated with the pathophysiology of major depressive disorder: A case-control study results

PLoS ONE, Год журнала: 2023, Номер 18(11), С. e0294288 - e0294288

Опубликована: Ноя. 15, 2023

Major Depressive Disorder (MDD) is a debilitating mental health condition with complex etiology, and recent research has focused on pro-inflammatory cytokines chemokines as potential contributors to its pathogenesis. However, studies investigating the roles of TNF-α MCP-4 in MDD within Bangladeshi population are scarce. This study aimed assess association between serum levels severity MDD, exploring their risk indicators for development.This case-control enrolled 58 patients from Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital, Dhaka, Bangladesh, alongside 30 age, sex, BMI-matched healthy controls. diagnosis followed DSM-5 criteria disease using 17-item Hamilton Depression Rating Scale (Ham-D). We measured ELISA assays according supplied protocols.The revealed significantly elevated (47±6.6 pg/ml, mean±SEM) compared controls (28.06±1.07 pg/ml). These increased positively correlated Ham-D scores (Pearson's r = 0.300, p 0.038), suggesting peripheral pathology. Additionally, exhibited higher (70.49±6.45 pg/ml) than (40.21±4.08 showed significant negative correlation (r -0.270, P 0.048) patients, indicating more role pathogenesis.This highlights that exhibit heightened inflammatory immune responses controls, supporting cytokine hypothesis Serum TNF-α, but not MCP-4, shows promise biomarker assessing development, which could aid early detection. Future investigations involving larger populations longitudinal essential confirm utility these biomarkers MDD.

Язык: Английский

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Interleukin-1β rs16944 and rs1143627 polymorphisms and risk of developing major depressive disorder: A case-control study among Bangladeshi population

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0317665 - e0317665

Опубликована: Янв. 22, 2025

Background Epidemiological research suggests that altered levels of cytokine are associated with pathophysiology and the development major depressive disorder (MDD). Based on earlier study, IL-1β rs16944 rs1143627 polymorphisms may increase risk depression. Here, we aimed to evaluate correlation between these MDD susceptibility among population in Bangladesh. Methods Blood samples were collected from 100 patients 70 matched controls. Study participants evaluated by DSM-5 criteria PCR-RFLP method applied for genotyping. Results The IL1β found have a significant association MDD. In case CT heterozygous genotype (OR = 2.22, 95% CI 1.08–4.55, p-value 0.029) combined CT+TT 2.35, 1.15–4.79, 0.019) was strongly increased comparison CC common genotype. Moreover, over-dominant model indicated 2.15-fold higher 2.15, 1.05–4.40, 0.036). On other hand, revealed TC+CC dominant showed 2.06-fold compared TT homozygote 2.06, 1.06–3.99, 0.032). Conclusion Studies an These findings will provide us valuable insights into

Язык: Английский

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