Chronic Hepatitis B Virus Infection and HLA Variations in a Greek Population

Viruses, Год журнала: 2025, Номер 17(4), С. 462 - 462

Опубликована: Март 24, 2025

Chronic hepatitis B is linked with considerable liver-related morbidity and mortality globally. Human leukocyte antigen (HLA) polymorphisms affect the susceptibility outcome of many immune-mediated diseases infections. Our aim was to study impact HLA alleles on HVB-infected individuals in a Greek population. In total, 107 patients chronic HBV infection (cHBV group) 101 spontaneous clearance (SC-group) surface (HBsAg) were genotyped for HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 loci by single-specific primer polymerase chain reaction (PCR-SSP). The alleles’ frequencies compared between two patient groups healthy from North Greece Bone Marrow Donor Registry (14506 samples). We found significantly increased frequency HLA-C*01 HLA-DRB1*16 cHBV group versus SC-group. HLA-A*01, HLA-B*08, HLA-C*01, HLA-C*08, HLA-DRB1*03, HLA-DQB1*05 higher individuals, while HLA-B*38 allele lower. showed an association specific either or protection against infection.

Язык: Английский

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Autoantibodies neutralizing type I interferons remain a significant risk factor for critical COVID-19 pneumonia in vaccinated patients

Clinical Immunology, Год журнала: 2025, Номер 276, С. 110491 - 110491

Опубликована: Апрель 4, 2025

Язык: Английский

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Role of Cytochrome P450 2C9 in COVID-19 Treatment: Current Status and Future Directions

European Journal of Drug Metabolism and Pharmacokinetics, Год журнала: 2023, Номер 48(3), С. 221 - 240

Опубликована: Апрель 24, 2023

The major human liver drug metabolising cytochrome P450 (CYP) enzymes are downregulated during inflammation and infectious disease state, especially coronavirus 2019 (COVID-19) infection. influx of proinflammatory cytokines, known as a 'cytokine storm', severe COVID-19 leads to the downregulation CYPs triggers new cytokine release, which further dampens CYP expression. Impaired metabolism, along with inevitable co-administration drugs or 'combination therapy' in patients various comorbidities, could cause drug–drug interactions, thus worsening condition. Genetic variability polymorphism CYP2C9 across different ethnicities contribute susceptibility. A number used inducers inhibitors of, metabolised by, CYP2C9, might pharmacokinetic pharmacodynamic interactions. It is also worth mentioning that some interactions due altered activity other including CYP3A4. Isoniazid/rifampin for tuberculosis co-infection; lopinavir/ritonavir cobicistat/remdesivir combination therapy; multi-drug therapy ivermectin, azithromycin, montelukast acetylsalicylic acid, TNR4 therapy, all improved recovery COVID-19. However, inducers, both, plausibly isoforms lead treatment failure, hepatotoxicity serious side effects thromboembolism bleeding, observed combined use azithromycin/warfarin. Further, herbs inhibitors, showed anti-COVID-19 properties, silico predictions postulated phytochemical compounds inhibit SARS-CoV-2 virus particles. vaccines elicit immune responses activate turn suppresses expression be source compromised metabolism subsequent interaction. Future studies recommended determine regulation COVID-19, while recognising involvement possibly utilising target gene tackle ever-mutating SARS-CoV-2.

Язык: Английский

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Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes

Infection Genetics and Evolution, Год журнала: 2024, Номер 118, С. 105564 - 105564

Опубликована: Фев. 1, 2024

This pilot study aimed to investigate genetic factors that may have contributed the milder clinical outcomes of COVID-19 in Brazilian indigenous populations. 263 Indigenous from Araweté, Kararaô, Parakanã, Xikrin do Bacajá, Kayapó and Munduruku peoples were analyzed, 55.2% women, ages ranging 10 95 years (average 49.5 ± 20.7). Variants genes involved entry SARS-CoV-2 into host cell (ACE1 rs1799752 I/D, ACE2 rs2285666 C/T, rs73635825 A/G TMPRSS2 rs123297605 C/T), genotyped Amazon, treated during pandemic between 2020 2021. The distribution genotypes did not show any association with presence or absence IgG antibodies. Additionally, influence variations on severity disease was examined extensively because a significant number individuals experienced either mild symptoms no symptoms. It is worth noting frequencies risk alleles found be lower populations compared both continental Brazilians. Amazon people exhibited an ethnic-specific profile associated disease, which could explain unexpected response they demonstrated COVID-19, being less impacted than

Язык: Английский

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The immunogenetics of COVID-19

Immunogenetics, Год журнала: 2022, Номер 75(3), С. 309 - 320

Опубликована: Дек. 19, 2022

Язык: Английский

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Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance

Journal of Inflammation, Год журнала: 2023, Номер 20(1)

Опубликована: Март 20, 2023

Abstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. main COVID-19 and death is represented (or on chronic) failure distress syndrome (ARDS), often requiring hospital admission ventilator support. molecular pathogenesis COVID-19-related ARDS (by now termed c-ARDS) still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, local systemic biomarkers correlated with c-ARDS therapeutic options that target cell signalling pathways c-ARDS.

Язык: Английский

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Mini-review: Angiotensin- converting enzyme 1 (ACE1) and the impact for diseases such as Alzheimer’s disease, sarcopenia, cancer, and COVID-19

Frontiers in Aging, Год журнала: 2023, Номер 4

Опубликована: Янв. 23, 2023

Ageing has been associated with comorbidities, systemic low-grade of inflammation, and immunosenescence. Hypertension is the most common morbidity anti-hypertensives are used for more than 50%. Angiotensin-converting enzyme 1 inhibitors (ACEi) angiotensin II receptor blockers (ARB) control blood pressure but also seem to play a role in comorbidities such as Alzheimer’s disease, sarcopenia cancer. The impact due expression renin-angiotensin system (RAS) several tissues body fluids. (ACE1) linked oxidative stress, metabolism, inflammation. levels activity ACE1 under genetic polymorphisms have correlated susceptibility disease. In addition, some results found that ACEi ARB users present delayed cognitive decline reduced risk dementia. Regarding sarcopenia, RAS catabolic anabolic pathways muscle mass maintenance. studies, older adults using were highly benefited by exercise training. cancer, its products shown since their inhibition animal models modulates tumor microenvironment improves delivery chemotherapy drugs. Clinically, incidence colorectal cancer patients ARB. During pandemic COVID-19 it was ACE2 plays entry SARS-CoV-2 into host cell. genotypes an increased severe studies taking or presented better outcome.

Язык: Английский

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Role of FokI rs2228570 and Tru9I rs757343 Polymorphisms in the Mortality of Patients Infected with Different Variants of SARS-CoV-2

Archives of Medical Research, Год журнала: 2023, Номер 54(4), С. 310 - 318

Опубликована: Март 31, 2023

Язык: Английский

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A Clinical Qualification Protocol Highlights Overlapping Genomic Influences and Neuro-Autonomic Mechanisms in Ehlers–Danlos and Long COVID-19 Syndromes

Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(7), С. 6003 - 6023

Опубликована: Июль 17, 2023

A substantial fraction of the 15% with double-jointedness or hypermobility have traditionally ascertained joint-skeletal, cutaneous, and cardiovascular symptoms connective tissue dysplasia its particular manifestation as Ehlers-Danlos syndrome (EDS). The holistic ascertainment 120 findings in 1261 EDS patients added neuro-autonomic like headaches, muscle weakness, brain fog, chronic fatigue, dyspnea, bowel irregularity to those arthralgia skin laxity, 15 these shared post-infectious SARS-CoV-2 (long COVID-19). Underlying articulo-autonomic mechanisms guided a clinical qualification protocol that qualified DNA variants 317 genes having diagnostic utility for EDS, six them identical (F2-LIFR-NLRP3-STAT1-T1CAM1-TNFRSF13B) eighteen similar modifying COVID-19 severity/EDS, including ADAMTS13/ADAMTS2-C3/C1R-IKBKG/IKBKAP-PIK3C3/PIK3R1-POLD4/POLG-TMPRSS2/TMPRSS6-WNT3/WNT10A. Also, contributing severity were forty three genes, respectively, impacting mitochondrial functions well parts an overlapping gene network, entome, are hypothesized mediate cognitive-behavioral, neuro-autonomic, immune-inflammatory alterations conditions. further characterization long natural history genetic predisposition will be necessary before parallels can carefully delineated translated into therapies.

Язык: Английский

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Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding

Human Genomics, Год журнала: 2024, Номер 18(1)

Опубликована: Янв. 30, 2024

Abstract The present study investigated two single nucleotide polymorphisms (SNPs)—rs479200 and rs516651 in the host EGLN1 / PHD2 gene for their association with COVID-19 severity. A retrospective cohort of 158 patients from Indian population (March 2020 to June 2021) was enrolled. Notably, frequency C allele (0.664) twofold higher than T (0.336) severe patients. Here, we report a novel finding that rs479200 imparts high risk (odds ratio—6.214 (1.84–20.99) p = 0.003; 9.421 (2.019–43.957) 0.004), additive inheritance model (adjusted unadjusted, respectively).

Язык: Английский

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