The Evolving Challenge of Appropriate Antibiotics Use in Hospitalized COVID-19 Patients: A Systematic Literature Review

Antibiotics, Год журнала: 2024, Номер 13(6), С. 545 - 545

Опубликована: Июнь 12, 2024

The issue of bacterial infections in COVID-19 patients has received increasing attention. Scant data are available on the impact superinfection and antibiotic administration outcome hospitalized patients. We conducted a literature review from 1 January 2022 to 31 March 2024 assess current burden infection evidence for use Published articles providing were identified through computerized searches with search terms [(antibiotic) AND (COVID-19)] or [(antibiotic treatment) (COVID-19)]. PubMed SCOPUS databases searched 2024. No attempt was made obtain information about unpublished studies. English language restriction applied. quality included studies evaluated by tool recommended Joanna Briggs Institute. Both quantitative qualitative summarized means textual descriptions. Five hundred fifty-one identified, twenty-nine this systematic review. Of 29 studies, 18 prevalence patients; 4 reported efficacy early COVID-19; sepsis biomarkers improve use; 3 antimicrobial stewardship programs predictive models among COVID-19-hospitalized high 35% medium 62%. High rates hospital-acquired patients, ranging between 7.5 37.7%. A resistance rate developing infections, in-hospital mortality rate. evaluating multi-faceted interventions decreasing consumption lower mortality.

Язык: Английский

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Robust COVID-19 Vaccine Responses Despite Filarial Co-Infection: Insights from a Lymphatic Filariasis Cohort in Ghana

Vaccines, Год журнала: 2025, Номер 13(3), С. 312 - 312

Опубликована: Март 13, 2025

Background/Objectives: Although the COVID-19 pandemic has largely concluded, varied trajectories it followed in different regions of world remain incompletely understood. Intensive research is needed to fully grasp its course and implications for future global health challenges. Notably, milder trajectory Sub-Saharan Africa defied initial predictions. An emerging body evidence suggests that, addition continent’s younger average age lower prevalence relevant comorbidities, co-infections with helminths may have also impressively shaped pandemic’s region. Indeed, are renowned their ability modulate human immune responses, which, while potentially beneficial limiting excessive inflammation, could diminish vaccine efficacy impede viral clearance. This study investigated aspects intricate interactions between Lymphatic Filariasis (LF), a helminth infection caused by parasitic worms such as Wuchereria bancrofti, Brugia malayi, timori endemic various tropics. Methods: For this purpose, samples larger ongoing clinical trial (ethical approval codes: CHRPE/AP/525/17 325/21; registration number ISRCTN14042737) were collected from 222 individuals areas Ghana, along comprehensive demographic data. The include LF patients (n = 222) grouped according Lymphoedema (LE) stages, well vaccinated 81) non-vaccinated 141). All participants received ChAdOx1-S (also known Vaxzevria) developed University Oxford AstraZenca. expressions SARS-CoV-2 filarial-specific antibodies (IgG, IgA) accessed using ELISA, Luminex-based immunoassays employed measure expression variant-specific neutralizing antibodies. interplay responses factors was analyzed group comparisons Kruskal-Wallis or Mann-Whitney U tests. Results: results indicate that remarkable portion unvaccinated (56% IgA seropositive, 39% IgG seropositive) against despite no confirmed infection. identified robust antibody response vaccination, which independent degree pathology status. important observation reduced seropositive Ascaris lumbricoides (p 0.0264), highlighting an interaction roundworm COVID-19. Conclusions: concludes (AstraZeneca) triggers strong patients; however, filarial and/or soil-transmitted seropositivity might influence infection-induced response. These findings emphasize complexity infectious disease dynamics co-infected populations need decipher parasite-induced immunomodulatory mechanisms on vaccination.

Язык: Английский

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Formation of zinc oxide composites of doxycycline with high antibacterial activity based on DC-magnetron deposition of ZnO nanoscale particles on the drug surface

Applied Physics A, Год журнала: 2024, Номер 130(3)

Опубликована: Фев. 8, 2024

Язык: Английский

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Assessing the performance of non-toxic nanomagnetic modified deep eutectic solvents for tetracycline adsorption: Taguchi approach for optimization

Journal of Molecular Liquids, Год журнала: 2024, Номер 399, С. 124374 - 124374

Опубликована: Фев. 29, 2024

Язык: Английский

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Repositioning of Antibiotics in the Treatment of Viral Infections

Current Microbiology, Год журнала: 2024, Номер 81(12)

Опубликована: Окт. 26, 2024

Drug repurposing, also known as drug repositioning, is a currently tested approach by which new uses are being assigned for already drugs. In this case there antibiotics that used to combat bacterial infections. However, among the drugs have been studied possible antiviral activities. Therefore, aim of work carry out review studies could be repositioned treatment viral Among main demonstrated activity macrolides and glycopeptides. addition, several from group tetracyclines, fluoroquinolones, cephalosporins aminoglycosides their activity. These against both RNA DNA viruses, including recent pandemic virus SARS-CoV-2. Some these were selected in addition its immunomodulatory anti-inflammatory properties. Of present activity, many cases mechanisms action not exactly known. The use infections remains controversial generally accepted, since clinical trials required prove effectiveness. no antibiotic approved therapy. Hence necessary carried on can future

Язык: Английский

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Efficacy and limitations of repurposed drugs and vaccines for COVID-19

Journal of Medicine Surgery and Public Health, Год журнала: 2023, Номер 2, С. 100041 - 100041

Опубликована: Дек. 26, 2023

COVID-19 is a contagious, severe acute respiratory disease caused by the coronavirus named SARS-CoV-2. In this review, we have updated nature and evolution of SARS-CoV-2 from earlier coronaviruses, highlighting rate mutation pathogenicity virus over time. The long-term pathophysiological consequences due to application limitations repurposing previously established drugs used for treatment related symptoms been discussed efficacy newly developed vaccines against COVID-19. But these certain including post-COVID complications like tissue damage organ failure. We also summarized role natural supplements, physical exercise, yoga, adequate sleep. Additionally, possibilities using mesenchymal stem cell (MSC)-derived exosomes, in failure elaborated, however, further research on manipulating exosomes regeneration healing required.

Язык: Английский

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Photocatalyst Based on Nanostructured TiO2 with Improved Photocatalytic and Antibacterial Properties

Materials, Год журнала: 2023, Номер 16(24), С. 7509 - 7509

Опубликована: Дек. 5, 2023

This study shows an easy way to use electrochemistry and plasma layering make Cobalt-Blue-TiO2 nanotubes that are better at catalysing reactions. Once a titanium plate has been anodized, certain steps taken oxygen vacancies appear inside the TiO2 nanostructures. To find out how Co deposition method changed final catalyst's properties, it was put through electrochemical tests (to charge transfer resistance flat band potential) optical gap Urbach energy). The catalysts were also described in terms of their shape, ability stick surfaces, inhibit bacteria. When Cobalt electrochemically deposited Blue-TiO2 nanotubes, film with star-shaped structures made hydrophilic antibacterial. energy went down from 3.04 eV 2.88 up 1.171 3.836 using this method. Also, photodegradation artificial doxycycline (DOX) water carried see useful results would be real life. These extra experiments meant show research could used life what benefits they might have. For bacterial tests, both gram-positive gram-negative bacteria used, BT/Co-E showed best response. Additionally, photoelectrodegradation conducted determine practical relevance findings. synergistic combination light applied potential leads 70% DOX degradation after 60 min irradiation.

Язык: Английский

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Exploring Cobalt Doping Methods for Enhancing Blue-TiO2 Catalyst Efficiency

Опубликована: Июль 11, 2023

This study presents a straightforward electrochemical and plasma deposition method for producing Cobalt-doped Blue-TiO2 nanotubes with enhanced catalytic properties. After titanium plate has been anodized, specific procedures are carried out that cause oxygen vacancies to form inside the TiO2 nanostructures. The obtained catalysts were subjected tests (to identify charge transfer resistance flat band potential), optical analysis determine gap Urbach energy) also characterized in terms of morphology, wettability antibacterial effect order understand analyze impact Co doping on final catalyst characteristics. A hydrophilic film star-shaped structures was created when cobalt electrochemically doped nanotubes. By using this technique, energy raised from 1.171 3.836 eV while decreased 3.04 2.88 eV. Additionally, photodegradation experiments artificial doxycycline (DOX) water conducted practical relevance research findings. In areas like antimicrobial applications DOX, these extra aimed show applicability potential advantages

Язык: Английский

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Machine Learning for COVID-19 Patient Management: Predictive Analytics and Decision Support

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 28, 2024

Abstract Background The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has profoundly affected economies and healthcare systems around the world, including Lebanon. While numerous meta-analyses have explored systemic manifestations COVID-19, few linked them to patient history. Our study aims fill this gap by using cluster analysis identify distinct clinical patterns among patients, which could aid prognosis guide tailored treatments. Methods We conducted a retrospective cohort at Beirut’s largest teaching hospital on 556 patients with SARS-CoV-2. performed analyses K-prototypes, KAMILA LCM algorithms based 26 variables, laboratory results, demographics imaging findings. Silhouette scores, concordance index signature variables helped determine optimal number clusters. Subsequent comparisons regression assessed survival rates treatment efficacy according Results revealed three clusters: “resilient recoverees” varying disease severity low mortality rates, “vulnerable veterans” critical high “paradoxical patients” late presentation but eventual recovery. Conclusions These clusters offer insights for selection. Future studies should include vaccination data various COVID-19 strains comprehensive understanding disease’s dynamics.

Язык: Английский

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Machine Learning for COVID-19 Patient Management: Predictive Analytics and Decision Support

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 14, 2024

Background. The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has profoundly affected economies and healthcare systems around the world, including Lebanon. While numerous meta-analyses have explored systemic manifestations COVID-19, few linked them to patient history. Our study aims fill this gap by using cluster analysis identify distinct clinical patterns among patients, which could aid prognosis guide tailored treatments. Methods.We conducted a retrospective cohort at Beirut's largest teaching hospital on 556 patients with SARS-CoV-2. We performed analyses K-prototypes, KAMILA LCM algorithms based 26 variables, laboratory results, demographics imaging findings. Silhouette scores, concordance index signature variables helped determine optimal number clusters. Subsequent comparisons regression assessed survival rates treatment efficacy according Results. Our revealed three clusters: "resilient recoverees" varying disease severity low mortality rates, "vulnerable veterans" high "paradoxical patients" late presentation but eventual recovery. Conclusions. These clusters offer insights for selection. Future studies should include vaccination data various COVID-19 strains comprehensive understanding disease's dynamics.

Язык: Английский

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