Progress of mesenchymal stem cells (MSCs) & MSC-Exosomes combined with drugs intervention in liver fibrosis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116848 - 116848

Опубликована: Июнь 3, 2024

Liver fibrosis is an intrahepatic chronic damage repair response caused by various reasons such as alcoholic liver, fatty viral hepatitis, autoimmune diseases, etc., and closely related to the progression of liver disease. Currently, mechanisms its treatment are hot research topics in field disease remedy. Mesenchymal stem cells (MSCs) a class adult with self-renewal multidirectional differentiation potential, which can ameliorate through hepatic-directed differentiation, paracrine effects, immunomodulation. However, low inner-liver colonization rate, survival short duration intervention after cell transplantation have limited their wide clinical application. With intensive on worldwide, it has been found that MSCs MSCs-derived exosomes combined drugs shown better efficiency than utilization alone many animal models fibrosis. In this paper, we review interventional effects mesenchymal alleviate hepatic vivo recent years, will provide new ideas improve efficacy treating clinic.

Язык: Английский

Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Апрель 23, 2024

Язык: Английский