Fortifying defenses: Tactical safety protocols for COVID-19 sub-variant JN.1 in healthcare and laboratory settings
Journal of Family Medicine and Primary Care,
Год журнала:
2025,
Номер
14(1), С. 78 - 84
Опубликована: Янв. 1, 2025
A
BSTRACT
Introduction:
Primary
care
physicians
are
crucial
in
fighting
COVID-19,
especially
with
the
emergence
of
new
JN.1
sub-variant.
Measures
to
Reduce
Risk:
Given
your
direct
exposure
infected
patients,
it
is
imperative
establish
a
protocol
for
triaging
patients
respiratory
symptoms
and
uphold
minimum
distance
2
meters
between
primary
physicians.
Patients
suspected
or
diagnosed
sub-variant
should
be
advised
wear
surgical
masks
their
protection
others
protection.
must
also
use
personal
protective
equipment
(PPE)
maintain
strict
hand
hygiene
practices
when
dealing
these
patients.
Patient
samples
treated
as
high
risk
contamination,
laboratory
procedures
meticulously
evaluated
potential
hazards.
PPE
tailored
procedure.
Conclusion:
To
protect
health
well-being
physicians,
who
play
critical
role
addressing
challenges,
essential
strictly
adhere
infection
control
measures.
Язык: Английский
Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics
Vaccine,
Год журнала:
2025,
Номер
54, С. 126960 - 126960
Опубликована: Март 7, 2025
Язык: Английский
SARS-CoV-2 mucosal neutralising immunity after vaccination
The Lancet Infectious Diseases,
Год журнала:
2023,
Номер
24(1), С. e4 - e5
Опубликована: Дек. 6, 2023
Язык: Английский
Autoimmune Sequelae After Delta or Omicron Variant SARS-CoV-2 Infection in a Highly Vaccinated Cohort
JAMA Network Open,
Год журнала:
2024,
Номер
7(8), С. e2430983 - e2430983
Опубликована: Авг. 30, 2024
Studies
have
reported
increased
risk
of
autoimmune
sequelae
after
SARS-CoV-2
infection.
However,
may
potentially
be
attenuated
by
milder
Omicron
(B.1.1.529)
variant
infection
and
availability
booster
vaccination.
Язык: Английский
Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 18, 2024
Abstract
Emerging
SARS-CoV-2
variants
require
rapid
assessments
of
pathogenicity
and
evasion
existing
immunity
to
inform
policy.
A
crucial
component
these
is
accurate
estimation
serum
neutralising
antibody
titres
using
cultured
live
virus
isolates.
Here,
we
report
our
updated
culture
methods
for
Omicron
sub-variant
JN.1
Caco-2
cells
the
subsequent
evaluation
(nAbTs)
in
recipients
BNT162b2-XBB.1.5
monovalent
Ancestral/BA.5
containing
bivalent
vaccines.
We
compared
either
Vero
V1
or
cells,
finding
resulted
low-titre
stocks
induced
mutations
at
Spike
furin
cleavage
site.
Using
sequence-clean
generated
assessed
samples
from
71
healthy
adults
eligible
a
COVID-19
vaccination
given
as
5
th
dose
booster:
all
participants
had
detectable
nAbs
against
prior
vaccination,
with
baseline/pre-existing
nAbTs
between
both
vaccine
groups
comparable
(p
=
0.240).
However,
post-vaccination
were
2.6-fold
higher
XBB1.5
than
BA.4/5
(p<0.001).
Regular
re-appraisal
involved
new
required
ensure
robust
data
are
used
underpin
severity
arise
strain
selection
decisions.
Язык: Английский
COVID-19 infections in English schools and the households of students and staff 2020–21: a self-controlled case-series analysis
International Journal of Epidemiology,
Год журнала:
2024,
Номер
53(4)
Опубликована: Июнь 12, 2024
Abstract
Background
The
role
of
children
and
staff
in
SARS-CoV-2
transmission
outside
within
households
is
still
not
fully
understood
when
large
numbers
are
regular,
frequent
contact
schools.
Methods
We
used
the
self-controlled
case-series
method
during
alpha-
delta-dominant
periods
to
explore
incidence
infection
around
a
household
member
infection,
relative
without
cohort
primary
secondary
English
schoolchildren
from
November
2020
July
2021.
Results
found
students
was
highest
1–7
days
following
remaining
high
up
14
after,
with
risk
also
elevated
6–-12
before
infection.
Younger
had
higher
suggesting
may
play
more
prominent
compared
older
students.
among
alpha
variant
dominant
period.
Conclusions
This
analysis
suggests
SARS-CoV2
children,
young
people
at
schools
were
likely
be
associated
within-household
than
household,
but
that
small
increased
seeding
observed.
Язык: Английский
Cycle Threshold Values of SARS-CoV-2 RT-PCR during Outbreaks in Nursing Homes: A Retrospective Cohort Study
Epidemiologia,
Год журнала:
2024,
Номер
5(4), С. 658 - 668
Опубликована: Окт. 16, 2024
Backgound/Objectives:
Cycle
threshold
(Ct)
values
of
SARS-CoV-2
real-time
reverse
transcriptase-polymerase
chain
reaction
(RT-PCR)
tests
are
associated
with
infectivity
and
viral
load,
they
could
be
an
aid
in
forecasting
the
evolution
outbreaks.
The
objective
was
to
know
Ct
related
incidence
reinfection
successive
outbreaks,
which
took
place
nursing
homes
Castellon
(Spain)
during
2020–2022,
test
its
usefulness
as
instrument
epidemic
surveillance
homes.
Methods:
a
retrospective
cohort
design
Poisson
regression
multinomial
logistic
were
used.
Results:
We
studied
four
home
average
infection
rate,
case
fatality
72.7%,
19.9%,
5.5%,
respectively;
98.9%
residents
vaccinated
three
doses
mRNA
vaccine.
for
first
infections
reinfections
27.1
±
6.6
31.9
5.4
(p
=
0.000).
Considering
≥
30
versus
<30,
had
higher
than
infection,
adjusted
relative
risk
1.66
(95%
Confidence
interval
1.10–2.51).
A
sensitivity
analysis
confirmed
these
results.
Conclusions:
Reinfection
vaccination
(hybrid
immunity)
protect
against
severe
disease
better
alone.
High
suggest
lower
transmission
severity.
Its
value
can
useful
future
epidemics.
Язык: Английский
Recent Vaccination Against SARS-CoV-2 Is Associated with Less Severe Disease in Working-Age Adults
International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(11), С. 1501 - 1501
Опубликована: Ноя. 12, 2024
Essential
workers,
including
those
working
in
healthcare
and
education,
are
at
higher
risk
of
exposure
to
communicable
diseases,
SARS-CoV-2.
Reducing
the
rates
infection
is
important
for
their
personal
health
ongoing
safe
operation
essential
services.
Язык: Английский