Recent Vaccination Against SARS-CoV-2 Is Associated with Less Severe Disease in Working-Age Adults DOI Open Access

Kailey Fischer,

Joanne M. Langley, Robyn Harrison

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(11), С. 1501 - 1501

Опубликована: Ноя. 12, 2024

Essential workers, including those working in healthcare and education, are at higher risk of exposure to communicable diseases, SARS-CoV-2. Reducing the rates infection is important for their personal health ongoing safe operation essential services.

Язык: Английский

Fortifying defenses: Tactical safety protocols for COVID-19 sub-variant JN.1 in healthcare and laboratory settings DOI Creative Commons
Shazima Sheereen, Mohnish Zulfikar Manva, Shamama Sheereen

и другие.

Journal of Family Medicine and Primary Care, Год журнала: 2025, Номер 14(1), С. 78 - 84

Опубликована: Янв. 1, 2025

A BSTRACT Introduction: Primary care physicians are crucial in fighting COVID-19, especially with the emergence of new JN.1 sub-variant. Measures to Reduce Risk: Given your direct exposure infected patients, it is imperative establish a protocol for triaging patients respiratory symptoms and uphold minimum distance 2 meters between primary physicians. Patients suspected or diagnosed sub-variant should be advised wear surgical masks their protection others protection. must also use personal protective equipment (PPE) maintain strict hand hygiene practices when dealing these patients. Patient samples treated as high risk contamination, laboratory procedures meticulously evaluated potential hazards. PPE tailored procedure. Conclusion: To protect health well-being physicians, who play critical role addressing challenges, essential strictly adhere infection control measures.

Язык: Английский

Процитировано

0

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics DOI
Giulia Dowgier,

Agnieszka Hobbs,

David Greenwood

и другие.

Vaccine, Год журнала: 2025, Номер 54, С. 126960 - 126960

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

0

SARS-CoV-2 mucosal neutralising immunity after vaccination DOI Open Access
Edward J Carr, Giulia Dowgier, David Greenwood

и другие.

The Lancet Infectious Diseases, Год журнала: 2023, Номер 24(1), С. e4 - e5

Опубликована: Дек. 6, 2023

Язык: Английский

Процитировано

7

Autoimmune Sequelae After Delta or Omicron Variant SARS-CoV-2 Infection in a Highly Vaccinated Cohort DOI Creative Commons
Liang En Wee, Jue Tao Lim,

An Ting Tay

и другие.

JAMA Network Open, Год журнала: 2024, Номер 7(8), С. e2430983 - e2430983

Опубликована: Авг. 30, 2024

Studies have reported increased risk of autoimmune sequelae after SARS-CoV-2 infection. However, may potentially be attenuated by milder Omicron (B.1.1.529) variant infection and availability booster vaccination.

Язык: Английский

Процитировано

2

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 DOI Creative Commons
Giulia Dowgier,

Agnieszka Hobbs,

David Greenwood

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 18, 2024

Abstract Emerging SARS-CoV-2 variants require rapid assessments of pathogenicity and evasion existing immunity to inform policy. A crucial component these is accurate estimation serum neutralising antibody titres using cultured live virus isolates. Here, we report our updated culture methods for Omicron sub-variant JN.1 Caco-2 cells the subsequent evaluation (nAbTs) in recipients BNT162b2-XBB.1.5 monovalent Ancestral/BA.5 containing bivalent vaccines. We compared either Vero V1 or cells, finding resulted low-titre stocks induced mutations at Spike furin cleavage site. Using sequence-clean generated assessed samples from 71 healthy adults eligible a COVID-19 vaccination given as 5 th dose booster: all participants had detectable nAbs against prior vaccination, with baseline/pre-existing nAbTs between both vaccine groups comparable (p = 0.240). However, post-vaccination were 2.6-fold higher XBB1.5 than BA.4/5 (p<0.001). Regular re-appraisal involved new required ensure robust data are used underpin severity arise strain selection decisions.

Язык: Английский

Процитировано

0

COVID-19 infections in English schools and the households of students and staff 2020–21: a self-controlled case-series analysis DOI
Elliot McClenaghan, Patrick Nguipdop‐Djomo, Alex Lewin

и другие.

International Journal of Epidemiology, Год журнала: 2024, Номер 53(4)

Опубликована: Июнь 12, 2024

Abstract Background The role of children and staff in SARS-CoV-2 transmission outside within households is still not fully understood when large numbers are regular, frequent contact schools. Methods We used the self-controlled case-series method during alpha- delta-dominant periods to explore incidence infection around a household member infection, relative without cohort primary secondary English schoolchildren from November 2020 July 2021. Results found students was highest 1–7 days following remaining high up 14 after, with risk also elevated 6–-12 before infection. Younger had higher suggesting may play more prominent compared older students. among alpha variant dominant period. Conclusions This analysis suggests SARS-CoV2 children, young people at schools were likely be associated within-household than household, but that small increased seeding observed.

Язык: Английский

Процитировано

0

Cycle Threshold Values of SARS-CoV-2 RT-PCR during Outbreaks in Nursing Homes: A Retrospective Cohort Study DOI Creative Commons
Juan Carlos Gascó‐Laborda, María Gil, María Dolores Tirado Balaguer

и другие.

Epidemiologia, Год журнала: 2024, Номер 5(4), С. 658 - 668

Опубликована: Окт. 16, 2024

Backgound/Objectives: Cycle threshold (Ct) values of SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR) tests are associated with infectivity and viral load, they could be an aid in forecasting the evolution outbreaks. The objective was to know Ct related incidence reinfection successive outbreaks, which took place nursing homes Castellon (Spain) during 2020–2022, test its usefulness as instrument epidemic surveillance homes. Methods: a retrospective cohort design Poisson regression multinomial logistic were used. Results: We studied four home average infection rate, case fatality 72.7%, 19.9%, 5.5%, respectively; 98.9% residents vaccinated three doses mRNA vaccine. for first infections reinfections 27.1 ± 6.6 31.9 5.4 (p = 0.000). Considering ≥ 30 versus <30, had higher than infection, adjusted relative risk 1.66 (95% Confidence interval 1.10–2.51). A sensitivity analysis confirmed these results. Conclusions: Reinfection vaccination (hybrid immunity) protect against severe disease better alone. High suggest lower transmission severity. Its value can useful future epidemics.

Язык: Английский

Процитировано

0

Recent Vaccination Against SARS-CoV-2 Is Associated with Less Severe Disease in Working-Age Adults DOI Open Access

Kailey Fischer,

Joanne M. Langley, Robyn Harrison

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(11), С. 1501 - 1501

Опубликована: Ноя. 12, 2024

Essential workers, including those working in healthcare and education, are at higher risk of exposure to communicable diseases, SARS-CoV-2. Reducing the rates infection is important for their personal health ongoing safe operation essential services.

Язык: Английский

Процитировано

0