Synthesis, antimicrobial, antioxidant, tyrosinase inhibitory activities, and computational studies of novel chromen[2,3-c]pyrazole derivatives

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Язык: Английский

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Azithromycin mediated Copper nanocatalysis (Azi-Cu-Nps): Synthesis of Anthraquinone connected Xanthenes deri vatives and their antioxidant, antityrosinase, and cytotoxic activities

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141447 - 141447

Опубликована: Янв. 1, 2025

Язык: Английский

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Cu(II)-Catalyzed Synthesis of Pyrazolo[3,4-b]pyridine Derivatives and Their Potential Antibacterial and Cytotoxic Activities with Molecular Docking, DFT Calculation, and SwissADME Analysis

ACS Omega, Год журнала: 2024, Номер 10(1), С. 1643 - 1656

Опубликована: Дек. 25, 2024

The present work focuses on a newly synthesized pyrazolo[3,4-b]pyridine prepared by formal [3 + 3] cycloaddition using copper(II) acetylacetonate as the catalyst; efficient and effective mild reactions with high yields were obtained this method. compounds identified FT-IR, 1H 13C NMR, mass spectra (m/z) analyses. (2a–l) screened for several in vitro silico activities. Compound 2g showed impressive inhibitory activities against methicillin-resistant Staphylococcus aureus (MIC: 2 μg/mL), vancomycin-resistant Enterococci 8 piperacillin-resistant Pseudomonas aeruginosa, extended-spectrum beta-lactamase-producing Escherichia coli 4 μg/mL) compared to positive control, ciprofloxacin. Compared standard doxorubicin, compound had higher efficacy HepG2 cancer cell line, GI50 value of 0.01 μM. highly active was investigated molecular docking, density functional theory calculations (DFT), SwissADME physicochemical properties. docking score (−8.5 vs −7.3 −10.0 −8.4 kcal/mol). In 2g, energy gap 0.17 eV, determined DFT calculations. properties all SwissADME. Overall, exhibited promising antibacterial cytotoxic

Язык: Английский

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Isolation of Natural Veratrylidenehydrazide Compound from Wedelia Biflora and Synthesis of Veratrylidenehydrazide Analogue: Investigation of Larvicidal Activity Against Culex Quinquefasciatus and Toxicity Analysis in Nontarget Aquatic Species

ChemistrySelect, Год журнала: 2024, Номер 9(42)

Опубликована: Ноя. 1, 2024

Abstract In this study, veratrylidenehydrazide was isolated from Wedelia biflora , and compounds ( 1a 2a 3a–j ) were synthesised to evaluate their larvicidal antifeedant activities. Veratrylidenehydrazide verified using GC‐MS. The analogues via a condensation method with yield range 71%–92%. characterised through FT–IR, 1 H NMR, 13 C mass spectrometry, elemental analysis. GC‐MS Natural compound the screened for activity against Culex quinquefasciatus . of 3g found be highly active, while low toxicity observed Oreochromis mossambicus nontarget aquatic species compared natural veratrylidenehydrazide. Compound exhibited higher binding affinity (−8.8 kcal/mol) standard temephos (−4.5 kcal/mol), equipotential permethrin (−9.1 diflubenzuron (−8.5 kcal/mol). Lead molecules have properties, use as insecticides makes them important.

Язык: Английский

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Synthesis of 4-Hydroxy Coumarin Hybrid with 2H-Thiopyran and Imidazolidine-2,4-Dione Derivatives and the Investigation of their Antimicrobial, Anticoagulant and Cytotoxic Activities, and Molecular Docking

Chemistry Africa, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Язык: Английский

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