Probiotic, Postbiotic, and Paraprobiotic Effects of Lactobacillus rhamnosus as a Modulator of Obesity-Associated Factors
Foods,
Год журнала:
2024,
Номер
13(22), С. 3529 - 3529
Опубликована: Ноя. 5, 2024
Obesity
is
a
pandemic
currently
affecting
the
world's
population
that
decreases
quality
of
life
and
promotes
development
chronic
non-communicable
diseases.
Язык: Английский
Microbiome metabolic capacity is buffered against phylotype losses by functional redundancy
Applied and Environmental Microbiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
ABSTRACT
Many
animals
contain
a
species-rich
and
diverse
gut
microbiota
that
likely
contributes
to
several
host-supportive
services
include
diet
processing
nutrient
provisioning.
Loss
of
microbiome
taxa
their
associated
metabolic
functions
as
result
perturbations
may
in
loss
microbiome-level
reduction
capacity.
If
are
shared
by
multiple
(i.e.,
functional
redundancy),
including
deeply
divergent
lineages,
then
the
impact
taxon/function
losses
be
dampened.
We
examined
what
degree
alterations
phylotype
diversity
Feeding
two
nutritionally
imbalanced
diets
omnivorous
Periplaneta
americana
over
8
weeks
reduced
phylotype-rich
microbiomes
~25%
based
on
16S
rRNA
gene
amplicon
sequencing,
yet
PICRUSt2-inferred
pathway
richness
was
largely
unaffected
due
being
polyphyletic.
concluded
nonlinearity
between
taxon
is
members
sharing
many
well-characterized
functions,
with
lineages
remaining
after
perturbation
potentially
capable
preventing
“service
outages”
redundancy.
IMPORTANCE
Diet
can
affect
taxonomic
composition
diversity,
but
its
impacts
community-level
capabilities
less
clear.
Host
health
fitness
increasingly
linked
further
modeling
relationship
capability
needed
inform
these
linkages.
Invertebrate
animal
models
like
American
cockroach
ideal
for
this
inquiry
because
they
amenable
various
provide
high
replicates
per
treatment
at
low
costs
thus
enabling
rigorous
statistical
analyses
hypothesis
testing.
Microbiome
diet-labile
feeding
unbalanced
post-treatment),
predicted
capacities
post-treatment
were
affected
resilience
abundant
surviving
well
taxa.
These
results
suggest
both
profiles
should
considered
when
attempting
infer
how
altering
possible
host
outcomes.
Язык: Английский
Impact of obesity on infarct size, circulating biomarkers, mitochondrial function and mortality in a Göttingen minipig myocardial infarct model
Lab Animal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Obesity
is
a
risk
factor
for
the
development
of
coronary
artery
disease
and
myocardial
infarction
(MI).
However,
most
large
animal
studies
MI
are
performed
in
lean
animals.
Here
we
assessed
impact
obesity
on
echocardiographic
findings,
infarct
size,
circulating
biomarkers,
mitochondrial
respiratory
capacity
mortality
closed-chest
minipig
model
MI.
The
initial
study
population
consisted
20
obese
(median
60.0
kg
[interquartile
range
55.9-64.6
kg])
18
(25.0
[23.4-36.5
female
Göttingen
minipigs.
duration
induction
using
western-style
diet
was
up
to
approximately
6
months
(156
days
[24-162
days])
before
by
120-min
balloon
occlusion
left
anterior
descending
feasible
17
Mortality
higher
compared
with
animals
(53%
versus
12%),
driven
primarily
refractory
ventricular
fibrillation
during
occlusion.
Electrocardiographic
findings
showed
longer
QRS
QT
intervals
more
extensive
ST-segment
elevation
Plasma
concentrations
pro-atrial
natriuretic
peptide,
pro-C-type
peptide
cardiac
troponin
T
were
significantly
lower
Infarct
size
estimated
8
weeks
after
smaller
(10%
[9-11%])
(13%
[13-15%]).
Finally,
mitochondrial-complex-I-linked
overall
animals;
however,
no
group
difference
found
intrinsic
capacity.
Язык: Английский
Protocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig
STAR Protocols,
Год журнала:
2025,
Номер
6(2), С. 103774 - 103774
Опубликована: Апрель 16, 2025
Язык: Английский
Dietary polyunsaturated fatty acids effect on cecal microbiome profile of maturing broiler chicken
Poultry Science,
Год журнала:
2025,
Номер
unknown, С. 105167 - 105167
Опубликована: Апрель 1, 2025
Язык: Английский
Synergistic Interplay of Diet, Gut Microbiota, and Insulin Resistance: Unraveling the Molecular Nexus
Molecular Nutrition & Food Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 16, 2024
Abstract
This
comprehensive
review
explores
the
intricate
relationship
between
gut
microbiota,
diet,
and
insulin
resistance,
emphasizing
novel
roles
of
diet‐induced
microbial
changes
in
influencing
metabolic
health.
It
highlights
how
diet
significantly
influences
microbiota
composition,
with
different
dietary
patterns
fostering
diverse
communities.
These
microbiome
impact
human
metabolism
by
affecting
inflammation,
energy
balance,
sensitivity,
particularly
through
metabolites
like
short‐chain
fatty
acids
(SCFAs).
Focusing
key
mediators
endotoxemia
systemic
introduces
personalized
microbiome‐based
therapeutic
strategies,
it
also
investigates
effects
components—fiber,
polyphenols,
lipids—on
along
protein
intake
amino
acid
metabolism.
The
study
compares
Western
Mediterranean
diets
on
microbiota‐insulin
resistance
axis.
Therapeutic
implications,
including
probiotics,
fecal
transplantation
(FMT),
diets,
are
discussed.
Key
findings
reveal
that
high‐fat
especially
those
rich
saturated
fats,
contribute
to
dysbiosis
increased
intestinal
permeability,
while
high‐fiber
promote
beneficial
bacteria
SCFAs.
underscores
future
potential
food
interventions
for
preventing
or
managing
resistance.
Язык: Английский
Effect of exclusive enteral nutrition on gut microbiota in Malaysian children with Crohn’s disease
IOP Conference Series Earth and Environmental Science,
Год журнала:
2024,
Номер
1408(1), С. 012003 - 012003
Опубликована: Окт. 1, 2024
Abstract
Paediatric
Crohn’s
disease
(pCD),
once
primarily
observed
in
Western
countries,
is
now
experiencing
a
global
increase
incidence
rates.
Southeast
Asian
nations,
including
Malaysia,
are
witnessing
gradual
of
pCD.
In
addition
to
clinical
symptoms,
children
with
(CD)
also
have
mental
and
emotional
impairments.
Children
CD
experience
gut
microbiota
dysbiosis.
Exclusive
enteral
nutrition
(EEN)
the
recommended
first
line
treatment
for
mild-to-moderate
pCD
due
its
multifaceted
disease-modulating
effects,
positive
re-modulation
diseased
microbiota.
However,
there
exists
critical
knowledge
gap
regarding
understanding
dynamics
individuals
treated
EEN,
particularly
regions
like
Malaysia.
This
study
aimed
fill
this
void
by
investigating
profile
Malaysian
CD,
making
it
kind
Using
targeted
16S
ribosomal
DNA
(16S
rDNA)
next-generation
sequencing,
identified
dominated
Fusobacterium
nucleatum
,
Haemophilus
parainfluenzae
mortiferum
Acidaminococcus
Monoglobus
among
patients
pCD,
latter
three
being
newly
relation
Following
successful
EEN
treatment,
enrichment
was
bacterial
groups
such
as
Lachnoclostridium
Parabacteroides
Eubacterium
fissicatena
group.
The
Clostridium
sensu
stricto
13
subterminale
Acetivibrio
ethanolgignens
group,
Robinsoniella
peoriensis
which
not
been
previously
associated
were
found
be
increased
following
treatment.
While
some
similarities
previous
literature
noted,
Malaysians
exhibited
several
novel
both
during
sheds
light
on
interplay
between
pathology,
emphasising
versatility
nutritional
therapy
approaches
diverse
populations.
Further
research
area
holds
promise
refining
strategies
improving
outcomes
individuals,
only
Malaysia
but
globally.
Язык: Английский
Characterization of the hepatic flora and metabolome in nonalcoholic fatty liver disease
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 20, 2024
The
purpose
of
this
study
was
to
examine
the
hepatic
bacterial
composition
and
metabolome
characteristics
patients
with
NAFLD
using
16S
rDNA
sequencing
metabolomics.
results
revealed
substantial
differences
in
metabolites
between
group
control
group.
These
were
used
identify
potential
biomarkers
that
could
be
employed
diagnose
NAFLD.
Liver
tissues
from
13
12
collected
for
microbiota
examination.
DNA
profiles
liver
significantly
different
controls.
exhibited
an
enrichment
Enterobacterales,
Mycobacteriales,
Pseudomonadales,
Flavobacteriales
Xanthomonadales,
Sphingomonadales,
Lysobact,
which
characterised
by
a
lack
erales.
At
genus
level,
abundance
values
Escherichia-Shigella,
Rhodococcus,
Chryseobacterium
elevated,
while
Stenotrophomonas,
Lawsonella
Sphingobium
reduced.
A
total
402
distinct
identified
two
groups,
78
up-regulated
14
down-regulated.
metabolic
pathways
indicated
linoleic
acid
metabolism
most
significant
contributor
differences,
lipid
substantially
differentiated.
metabolite
levels
correlated
changes
microflora,
as
demonstrated
correlation
analysis.
Differences
pathogenesis
host
physiological
function
may
attributed
flora
metabolomic
characteristics.
In
future,
presents
new
opportunities
investigation
prospective
diagnostic
therapeutic
targets
Язык: Английский