Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety

Medicinal Research Reviews, Год журнала: 2024, Номер 45(1), С. 311 - 343

Опубликована: Авг. 24, 2024

Drug safety is a paramount concern in the field of drug development, with researchers increasingly focusing on bidirectional regulation gut microbiota this context. The plays crucial role maintaining safety. It can influence transport processes body through various mechanisms, thereby modulating their efficacy and toxicity. main mechanisms include: (1) directly interacts drugs, altering chemical structure to reduce toxicity enhance efficacy, impacting drugs also change abundance bacteria; (2) intestinal barrier permeability by microbiota, promoting absorption nontoxic inhibiting toxic components; (3) expression activity proteins selectively effective components or components. This regulatory enables play key balance reducing adverse reactions. Understanding these sheds light novel approaches minimize side effects, ultimately improve review systematically examines transportation from aforementioned aspects, emphasizing significance ensuring Furthermore, it offers prospective outlook standpoint enhancing therapeutic toxicity, underscoring importance further exploration research domain. aims provide more strategies for development treatment.

Язык: Английский

Influenza and the gut microbiota: A hidden therapeutic link

Heliyon, Год журнала: 2024, Номер unknown, С. e37661 - e37661

Опубликована: Сен. 1, 2024

The extensive community of gut microbiota significantly influences various biological functions throughout the body, making its characterization a focal point in biomedicine research. Over past few decades, studies have revealed potential link between specific bacteria, their associated metabolic pathways, and influenza. Bacterial metabolites can communicate directly or indirectly with organs beyond via intestinal barrier, thereby impacting physiological host. As increasingly emerges as 'gut signature' influenza, gaining deeper understanding role may offer new insights into pathophysiological relevance open avenues for novel therapeutic targets. In this Review, we explore differences healthy individuals those relationship strategies preventing treating influenza through regulation metabolites, including fecal transplantation microecological preparations.

Язык: Английский

Integrative Metabolomic and Microbiomic Profiling: Unveiling the Therapeutic Mechanisms of Yangyinqingfei Decoction in Acute Lung Injury

Food Bioscience, Год журнала: 2024, Номер 62, С. 105432 - 105432

Опубликована: Ноя. 7, 2024

Язык: Английский