HIV-1 Tat protein alters medial prefrontal cortex neuronal activity and recognition memory

iScience, Год журнала: 2025, Номер 28(3), С. 112075 - 112075

Опубликована: Фев. 22, 2025

Despite advancements in combined antiretroviral therapy, human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) continue to affect 40%-50% of people living with HIV. While neuroimaging studies have revealed HIV-1-induced alterations cortical networks and brain macrostructures, it still remains unclear how individual neurons the medial prefrontal cortex (mPFC) are affected during recognition memory. Using vivo calcium imaging an HIV-1 transactivator transcription (Tat) transgenic mouse model, we examined mPFC neuronal activity a novel object memory task. Our findings show that HIV Tat expression reduces overall Tat(+) mice without altering number activated cells. Moreover, distinct subpopulations up- downmodulated both Tat(-) depending on exploration. Importantly, familiarity-driven increases were disrupted by expression. These enhance our understanding HAND may inform future pharmacological strategies aimed at restoring cognitive function.

Язык: Английский

Animal models of neuropathic pain

International review of neurobiology, Год журнала: 2024, Номер unknown, С. 339 - 401

Опубликована: Янв. 1, 2024

Язык: Английский