Ureaplasma urealyticum upregulates seminal fluid leukocytes and lowers human semen quality: a systematic review and meta-analysis
Omotola SeunFunmi Kukoyi,
Victory Jesutoyosi Ashonibare,
Cecilia Adedeji Adegbola
и другие.
Basic and Clinical Andrology,
Год журнала:
2025,
Номер
35(1)
Опубликована: Апрель 17, 2025
Abstract
Background
Ureaplasma
urealyticum
belongs
to
the
class
Mollicutes
and
causes
non-gonococcal
urethritis,
an
inflammation
of
urethra
that
is
linked
with
impaired
semen
quality.
However,
some
reports
are
contradictory,
reported
effect
U.
on
specific
sperm
variables
not
consistent.
Thus,
this
study
synthesized
findings
from
published
primary
data
provides
a
robust
reliable
inference
impact
associated
mechanisms
Methods
A
systematic
search
was
conducted
until
31st
May,
2024,
Cochrane,
Google
Scholar,
Pubmed.
The
Population,
Exposure,
Comparator/Comparison,
Outcomes,
Study
Design
(PECOS)
model
adopted.
populations
were
male
in
their
reproductive
ages
who
infected
confirmed
positive
versus
control
age-matched
non-infected
or
treated,
while
outcomes
included
conventional
parameters,
seminal
fluid
leucocyte
count,
interleukin-6
(IL-6)
concentrations,
studies
either
cross-sectional
longitudinal.
Results
When
compared
control,
quantitative
analysis
demonstrated
significantly
reduced
ejaculate
volume
(SMD
0.33
[95%
CI:
0.15,
0.52]
p
=
0.0004),
concentration
0.47
0.31,
0.64]
<
0.00001),
total
motility
0.73
0.43,
1.02]
motile
count
0.21
0.17,
0.26]
normal
morphology
0.88
0.42,
1.35]
0.0002),
but
increased
leukocyte
-0.82
-1.61,
-0.02]
0.04).
In
addition,
qualitative
revealed
urealyticum-
subjects
had
higher
levels
IL-1β,
IL-6,
IL-8,
TNF-α,
peroxidase,
leukocytes
,
neutrophils,
CD4
+
T
cells,
CD8
cells
when
control.
Furthermore,
DNA
fragmentation
apoptotic
observed
Conclusions
These
lowers
quality
via
upregulation
leukocytes,
elastase,
pro-inflammatory
cytokines,
fragmentation.
further
required
elucidate
underlying
association
between
decline
develop
effective
therapies
for
condition.
Язык: Английский
A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality
Frontiers in Toxicology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 17, 2024
Introduction
Triclosan
is
an
antibacterial
and
antifungal
compound
that
frequently
found
in
personal
care
consumer
products,
its
impact
on
male
reproductive
health
a
growing
concern.
Despite
existing
experimental
studies
demonstrating
potential
threats
to
fertility,
reports
effects
human
semen
quality
remains
limited
inconsistent.
Therefore,
this
study
presents
systematic
review
meta-analysis
assessing
the
relationship
between
triclosan
exposure
quality.
Methods
This
was
registered
with
PROSPERO
(CRD42024524192)
adhered
PRISMA
guidelines.
Results
The
analyzed
562
screened
studies,
out
of
which
five
articles
including
1,312
subjects
were
finally
included
study.
eligible
geographically
diverse,
three
from
China,
one
Belgium,
Poland.
More
so,
both
case-control
cross-sectional.
revealed
significantly
reduced
sperm
concentration
(Standard
Mean
Difference
(SMD)
−0.42
[95%
CI:
−0.75,
−0.10],
P
=
0.01)
total
motility
(SMD
−1.30
−2.26,
−0.34],
0.008).
Mechanistic
insights
animal
vitro
showed
oxidative
stress
may
mediate
adverse
Discussion
first
comprehensive
evaluation
quality,
highlighting
impair
fertility
through
reductions
motility.
However,
high
heterogeneity
among
underscores
need
for
further
high-quality
research
establish
more
definitive
conclusions
regarding
health.
Язык: Английский
Editorial: Environmental threats to human reproduction
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 2, 2024
These
environmental
stressors
acts
via
multiple
pathways.
First,
they
disrupt
the
endocrine
system
by
mimicking
or
blocking
sex
hormones
(Akhigbe
et
al.,
2022).
They
may
also
induce
oxidative
stress
upregulating
generation
of
free
radicals
and
suppressing
antioxidants
(Kumar
2018;Akhigbe
2021),
trigger
inflammation
immune
response
(Li
2021;Ashonibare
2024b),
promote
genotoxicity
(Choudhuri
2021)
Although
SARS-CoV-2
remains
quite
novel,
convincing
evidences
have
been
provided
on
its
possible
link
with
infertility
Hamed,
2020;Adeyemi
2022)
Язык: Английский
Prolactin Role in COVID-19 and Its Association with the Underlying Inflammatory Response
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 11905 - 11905
Опубликована: Ноя. 6, 2024
The
COVID-19
pandemic
has
prompted
interest
in
identifying
reliable
biomarkers
to
predict
disease
severity
and
guide
clinical
decisions.
Prolactin
(PRL),
a
hormone
traditionally
associated
with
lactation,
gained
attention
for
its
role
immune
modulation.
This
study
aimed
assess
PRL
as
biomarker
COVID-19.
A
prospective
cohort
of
142
patients
moderate
severe
COVID-19,
defined
WHO-CPS
5
or
6,
was
recruited
from
the
University
General
Hospital
Patras.
Baseline
levels
were
measured
using
an
electrochemiluminescence
immunoassay,
serum
cytokines,
including
IL-1β,
IL-6,
IL-8,
IL-10,
IL-12p70,
TNF-α,
quantified
through
flow
cytometry.
Clinical
outcomes,
mortality
need
invasive
mechanical
ventilation
(IMV),
recorded.
Results
indicated
that
significantly
higher
female
(12.95
ng/mL
vs.
9.40
ng/mL,
Язык: Английский