Tamarind seed gum-based hydrogel for the targeted delivery of imidazobenzothiazole sulfonamide derivative as an anticancer agent
Bhavya Balakrishnan,
B.K. Sarojini,
Bikrodi Sesappa Dayananda
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
295, С. 139665 - 139665
Опубликована: Янв. 8, 2025
Язык: Английский
Convenient Synthesis, Characterization, Evaluation and molecular docking of Some New Fused Pyrazolo[3,4-d]pyrimidine Derivatives and 3-Methyl-8 phenylpyrazolo[3',4':4,5]pyrimido[6,1-c][1,2,4]triazines Against Hela Cancer Cells
Tetrahedron,
Год журнала:
2025,
Номер
unknown, С. 134557 - 134557
Опубликована: Фев. 1, 2025
Язык: Английский
Apoptosis induction in ascorbic acid treated human colorectal cancer cell lines (Caco-2)
Naeimah Abdullah Mohammed Mustafa,
Mohamed A. El-Desouky,
Nessreen A. Shawush
и другие.
Journal of Biologically Active Products from Nature,
Год журнала:
2025,
Номер
15(1), С. 56 - 71
Опубликована: Янв. 2, 2025
Язык: Английский
Palladium‐Imidazole Nanoparticles' Cytotoxic Effects on Colon Cancer Cells: Induction of Cell Cycle Arrest and Apoptosis Mediated via Mitochondria
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
39(1)
Опубликована: Дек. 10, 2024
ABSTRACT
The
present
study
emphasized
the
potential
antitumor
activity
of
compound
A;
[Pd
(Im)
2
Cl
],
a
nano‐sized
coordination
with
size
23.76
nm.
Characterization
was
performed
using
elemental
analysis,
molar
conductance,
magnetic
measurement,
FTIR,
Ultraviolet–visible
(UV–vis)
spectroscopy,
thermal
mass
spectrometry,
and
NMR.
complex
showed
stability
up
to
300°C.
Furthermore,
compound's
formation
spontaneity
supported
by
activation
parameters
calculated
from
TGA.
di‐aqua
form
separated
solid
complex,
B
(H
O)
]
2+
,
successfully
prepared.
geometry
optimization
imidazole
its
complexes
that
both
were
more
stable
than
free
imidazole.
cis
exhibits
superior
potent
IC
50
value
5.72±0.68
μg/mL.
This
demonstrates
greater
inhibitory
impacts
on
Caco‐2
cancer
cell
proliferation
compared
].
Moreover,
cytoxicity
against
cells
confirmed
significant
increase
in
LDH
levels
treated
untreated
ones.
Treatment
markedly
raised
percentage
early
late
apoptotic
cells,
accompanied
Go/G1
phase
arrest
intense
comet
nucleus.
Apoptosis
induction
mediated
through
increased
reactive
oxygen
species
(ROS)
production.
expression
cleaved
Caspase‐3,
Bax,
P53
while
concurrently
dropping
Bcl‐2,
cyclin
D1,
CDK4.
Overall,
these
findings
indicate
triggers
cytotoxicity
dose‐dependent
manner,
primarily
via
ROS‐mediated
death,
possibly
mitochondrial
pathway.
Additionally,
active
selected
proteins
related
apoptosis
cycle
explored
theoretical
molecular
docking
results.
outcomes
also
validated
safety
healthy
suggesting
it
as
promising
treatment
option
for
colon
humans.
Язык: Английский
Berberine decorated zinc oxide loaded chitosan nanoparticles a potent anti cancer agent against breast cancer
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 25, 2025
Breast
cancer
ranks
as
the
second
leading
reason
of
mortality
among
females
globally,
emphasizing
critical
need
for
novel
anticancer
treatments.
In
current
work,
berberine-zinc
oxide
conjugated
chitosan
nanoparticles
were
synthesized
and
characterized
using
various
characterization
techniques.
The
cytotoxic
effects
CS-ZnO-Ber
NPs
on
MCF-7
cells
assessed
MTT
assay.
Also,
annexin
V-FITC/PI
double
staining,
Hoechst
33,342
caspases-8
9
activity
assays,
cell
cycle
analysis
performed.
Furthermore,
mRNA
levels
Bax
Bcl-2
genes
quantified
qPCR.
Additionally,
migration
was
evaluated
a
scratch
IC50
value
against
measured
7.41
µg/mL.
Apoptosis
induction
in
NP-treated
confirmed
by
Annexin
V/PI
accompanied
observation
condensed
chromatin
fragmented
DNA.
Moreover,
pro-apoptotic
potential
evidenced
significant
increases
decreased
Bcl-2/Bax
ratio.
arrest
at
sub-G1
noticed
treated
cells.
markedly
inhibited
rate
These
findings
suggest
that
induce
cell-cycle
activate
apoptotic
pathways
cells,
highlighting
their
hopeful
therapeutic
agent
breast
cancer.
Язык: Английский
Targeted delivery of Zingiber officinale Roscoe extract-loaded chitosan nanoparticles for inhibition of multidrug-resistant Escherichia coli-induced HCT-116 colon cancer
Clinical Phytoscience,
Год журнала:
2025,
Номер
11(1)
Опубликована: Март 27, 2025
Abstract
The
emergence
of
multidrug-resistant
(
MDR
)
Escherichia
coli
E.
is
a
growing
concern,
as
it
significantly
contributes
to
colon
cancer
initiation
and
progression.
Conventional
treatment
strategies
face
challenges
such
poor
bioavailability
antibiotic
resistance,
necessitating
the
development
targeted
therapies.
This
study
evaluates
efficacy
Zingiber
officinale
Roscoe
(ginger)
extract-loaded
chitosan
nanoparticles
GELCs
in
inhibiting
-induced
using
HCT-116
cell
line.
were
synthesized
with
an
average
size
150
±
5
nm,
zeta
potential
+
32.5
mV,
encapsulation
efficiency
84.3%.
Their
biological
activity
was
assessed
through
vitro
vivo
models,
focusing
on
antimicrobial
effects,
cytotoxicity,
apoptosis
induction,
inflammatory
modulation.
exhibited
potent
activity,
reducing
colony-forming
units
(CFUs)
by
83%
compared
untreated
co-cultures.
MTT
assay
results
showed
dose-dependent
reduction
viability,
IC₅₀
22.8
µg/mL
,
which
lower
than
that
free
ginger
extract
(IC₅₀
=
48.6
µg/mL),
indicating
enhanced
efficacy.
Flow
cytometry
analysis
confirmed
increased
apoptosis,
BAX/BCl-2
ratio
11.3
GELC
-treated
group
1.0
control
.
ELISA
assays
further
demonstrated
cytokines,
IL-6,
TNF-α,
IL-1β
levels
decreasing
54%,
61%,
47%
respectively.
These
findings
highlight
dual
anticancer
making
them
promising
candidate
for
therapy
against
-associated
cancer.
underscores
advantages
nanoparticle-based
delivery
systems
enhancing
therapeutic
natural
bioactive
compounds.
Язык: Английский
Hyaluronic Acid-Based pH-Sensitive Nanogel: Synthesis, Characterization, and Assessment for Acyclovir Delivery In Vitro and In Vivo
Biomacromolecules,
Год журнала:
2024,
Номер
26(1), С. 341 - 362
Опубликована: Дек. 25, 2024
Acyclovir
(ACV)
is
a
potentially
effective
antiviral
medication;
however,
it
has
serious
drawback,
which
its
poor
solubility,
bioavailability,
and
short
half-life.
The
goal
of
this
study
to
improve
drawbacks
through
the
synthesis
nanogels.
In
study,
cross-linked
hyaluronic
acid-grafted
poly(acrylamide-co-itaconic
acid)
nanogel
synthesized
successfully
free
radical
polymerization
used
as
safe
pH-responsive
carrier
for
ACV.
nanogels
showed
pH
response
in
vitro
vivo.
prepared
C5
(1:1
ratio
acrylamide:
itaconic),
had
highest
grafting
efficiency,
maximum
swelling,
drug
loading,
release
7.4,
higher
than
1.2.
Also,
C5,
large
surface
area,
good
stability,
matrices
shrank
acidic
medium
protected
drug,
while
basic
medium,
expanded
released
ACV
sustained
manner
improved
bioavailability
half-life
Язык: Английский