Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review DOI

Mohammad Ebrahim Astaneh,

Narges Fereydouni

International Journal of Polymeric Materials, Год журнала: 2024, Номер unknown, С. 1 - 33

Опубликована: Дек. 16, 2024

This review delves into the efficacy of electrospun nanofibers as structures capable neutralizing Reactive Oxygen Species (ROS), thereby aiding in acceleration wound repair. ROS occupy a dual position cellular dynamics, being indispensable for intracellular communication, yet they potentially exacerbate oxidative stress which can stall healing trajectory. The method electrospinning synthesizes distinguished by their expansive surface area relative to volume and notable porosity, rendering them optimally suited medical endeavors, particularly frameworks that bolster recuperation. analysis elucidates diverse roles these play, from enhancing clot formation combating microbial invasion mitigating inflammation, fostering proliferation, facilitating angiogenesis—each pivotal component effective mending wounds.

Язык: Английский

Green synthesis of selenium nanoparticles from Cassia javanica flowers extract and their medical and agricultural applications DOI Creative Commons
Mohamed K. Y. Soliman,

Mohamed A. Amin,

Abdelatti I. Nowwar

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 5, 2024

Abstract Nanostructured materials are advantageous within numerous fields of medicine owing to their intriguing qualities, which include size, reactive surface, bioactivity, potential for modification, and optical characteristics. Cassia javanica flower extract was used as a chelating agent in an environmentally friendly process create SeNPs FTIR, XRD, TEM, SAED were utilized analyze characterize the synthesized. The findings showed that MIC Se NPs against B. subtilis S. aureus 500 µg/ml. Conversely, P. aeruginosa , E. coli C. albicans 125, 250, 62.5 µg/ml, respectively. Hence, considerably reduced activity; inhibition peaked at 77.6% 250 µg/ml reach 49.04% 7.8 Which greatest suppression MRSA biofilm formation without affecting bacterial growth. antioxidant capacity, achieving IC 50 53.34 This study looked how soaking seeds before sowing them with 50, 100, 200 ppm affected plants’ development different parameters, well yield Vicia faba L. growth conditions effectively increased by application various quantities NPs. highest values dry weight/pod (g), number seeds/plant, weight 100 pods/plant caused high concentrations NPs, 28.43, 89.60, 18.20, 94.11%,

Язык: Английский

Процитировано

7

Biosynthesized zinc oxide nanoparticles: Multifunctional potential applications in anticancer, antibacterial, and B. subtilis DNA gyrase docking DOI Creative Commons
Samy Selim, Salem S. Salem, Medhat E. Owda

и другие.

Green Processing and Synthesis, Год журнала: 2025, Номер 14(1)

Опубликована: Янв. 1, 2025

Abstract In this work, extracts from okra fruit are used to create zinc oxide nanoparticles (ZnO NPs) in an economical and environmentally friendly manner. During the synthesis process, ( Abelmoschus esculentus ) served as stabilizing reducing agents. Various analytical methods were describe final nanoparticles. The outcomes showed that produced ZnO NPs primarily exhibited hexagonal shapes, with sizes ranging 20 27 nm diameter. cytotoxicity study, conducted on human fibroblast normal HFB4 cell lines, indicated IC 50 dose was 227.8 μg·mL −1 . of 119.7 found antitumor effect studies using breast adenocarcinoma Mcf-7 revealing a good level safety for NPs. Compared Gram-negative infections, have significantly higher anti-bacterial impact against Gram-positive pathogens. Molecular docking DNA gyrase A subunit Bacillus subtilis (PDB ID: 4DDQ) illustrated interlocked active site 4DDQ by fitting energy value −50.91 kcal·mol through three classical hydrogen bonds Asp96, Thr220, Ala221. last one is also generated marketing tromethamine drug (TRS), adding some TRS-like character NP inhibitor.

Язык: Английский

Процитировано

0

Investigation of the Effects of Applying Bio‐Magnesium Oxide Nanoparticle Fertilizer to Moringa Oleifera Plants on the Chemical and Vegetative Properties of the Plants’ leaves DOI Open Access
Ahmed Suliman, Camilia Y. El‐Dewiny, Mohamed K. Y. Soliman

и другие.

Biotechnology Journal, Год журнала: 2025, Номер 20(3)

Опубликована: Март 1, 2025

ABSTRACT Magnesium (Mg) is necessary for plants as a structural element or an enzyme cofactor. It also plays significant role in the light and dark responses of photosynthesis. Moringa are considered one most important medicinal that humans need nutrition. The aim study to provide Mg easy simple way. Therefore, it widely available human food due its nutritional importance. In this experiment, treatment was done on plant as, increasingly used fresh form. experiment conducted at research farm National Research Center. oxide has been extracted prepared natural way safe humans, plants, soil. Trichoderma viride filtrate chelating agent environmentally friendly process create magnesium nanoparticle (MgO‐NPs). FTIR, TEM, SEM‐EDX were utilized analyze characterize synthesized. Plants treated with different doses determine optimal concentration plant. effect improve vegetation such, number leaves (232.15), leaf area (273.97 cm 2 ), weight (3693.17 g). increased dry matter (171.8 g), chemical properties, elements.

Язык: Английский

Процитировано

0

A comprehensive study on characterization of biosynthesized copper-oxide nanoparticles, their capabilities as anticancer and antibacterial agents, and predicting optimal docking poses into the cavity of S. aureus DHFR DOI Creative Commons
Ehab S. Gad, Salem S. Salem, Samy Selim

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0319791 - e0319791

Опубликована: Апрель 1, 2025

The eco-friendly method of producing copperـoxide nanoparticles through the use okra fruit extract is a simple, economical, rapid, and sustainable technique. resultant (CuO NP) were analyzed with several analytical methods, such as UV-vis spectroscopy, FourierـTransform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD), Zeta potential, TransmissionـElectron Microscopy (TEM) EnergyـDispersive X-ray (EDX) analysis. CuO NP exhibited maximum absorbance at 381 nm. formation was further confirmed by characteristic bands observed 534 588 cm -1 . monoclinic structure identified prominent peaks detected 2θ values 32.47°, 35.43°, 38.64°, 48.68°, 53.38°, 58.14°, 61.39°, 66.11°, 67.82°, 72.27°, 74.96°. overall findings indicate that had an average diameter in approximate range 10 to 30 nm based on TEM cytotoxicity study, conducted Human Fibroblast normal HFB4 cell lines, indicated halfـmaximal inhibitory concentration (IC50) dose 236.34 μg/mL. An IC50 109.46 μg/mL found antitumor effect studies using breast adenocarcinoma Mcf- 7 revealing good level safety for NP. According antibacterial Staphylococcus aureus Bacillus cereus inhibition zone diameters (IZDs) 29.5 ± 0.7 mm 24.6 1.2 mm, respectively, making them most vulnerable bacteria In contrast, P. aeruginosa least sensitive strain, minimum IZD 15 1.6 mm. Compared gram-negative infections, NPs have significantly higher effectiveness versus Gram -positive pathogens. Molecular docking against dihydrofolate reductase (DHFR) (PDB ID: 6P9Z) illustrated partially interlocked active site 6P9Z fitting energy value -44.93 kcal/mol five classical hydrogen bonds Ala7, Gln9, Thr46, Ser49, Phe92. last one also generated marketing antifolate agent methotrexate (MTX), adding some MTX-like character inhibitor.

Язык: Английский

Процитировано

0

Gold Nanoparticles as the Sterilant in Large-Scale Micropropagation of Plants DOI
Abdelatti I. Nowwar, Azamal Husen, Salem S. Salem

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

1

Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review DOI

Mohammad Ebrahim Astaneh,

Narges Fereydouni

International Journal of Polymeric Materials, Год журнала: 2024, Номер unknown, С. 1 - 33

Опубликована: Дек. 16, 2024

This review delves into the efficacy of electrospun nanofibers as structures capable neutralizing Reactive Oxygen Species (ROS), thereby aiding in acceleration wound repair. ROS occupy a dual position cellular dynamics, being indispensable for intracellular communication, yet they potentially exacerbate oxidative stress which can stall healing trajectory. The method electrospinning synthesizes distinguished by their expansive surface area relative to volume and notable porosity, rendering them optimally suited medical endeavors, particularly frameworks that bolster recuperation. analysis elucidates diverse roles these play, from enhancing clot formation combating microbial invasion mitigating inflammation, fostering proliferation, facilitating angiogenesis—each pivotal component effective mending wounds.

Язык: Английский

Процитировано

0