Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 12, 2025

Luteolin is a flavonoid widely found in plants, including vegetables, botanical drugs, and fruits. Owing to its diverse pharmacological activities, such as anticancer, oxidative stress protection, anti-inflammatory, neuron-preserving effects, luteolin has attracted attention research medicine. exhibits therapeutic effects on various pulmonary disease models through multiple molecular mechanisms; these include inhibition of activation the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-κB) MAPK signaling pathways, well promotion regulatory T cell (Treg) function enhancement alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation responses). chronic obstructive (COPD), acute lung injury/acute respiratory distress syndrome (ALI/ARDS), fibrosis, allergic asthma, cancer. Luteolin, naturally occurring polyphenol, poorly water-soluble. The oral route may be ineffective because gut absorbs this type flavonoid. Therefore, although significant biological activity, clinical application limited by challenges associated with poor water solubility low bioavailability, which are critical factors for efficacy application. These can addressed modifying chemical structure enhancing pharmaceutical formulations. We summarized advancements improving bioavailability luteolin, diseases their related mechanisms, aim providing new ideas researchers.

Язык: Английский