The role of the microbiome in inflammation during tuberculosis DOI Creative Commons
Anou M. Somboro, Dramane Diallo, Jane L. Holl

и другие.

EBioMedicine, Год журнала: 2021, Номер 68, С. 103435 - 103435

Опубликована: Июнь 1, 2021

The human gut microbiota, comprised of a diverse microbial ecosystem, consists hundreds groups species that are relatively stable in healthy individuals, but its composition can change rapidly as result illness, age, diet, antibiotic use, host genetics, and inflammation. Recent reports have shown the microbiome may be implicated tuberculosis (TB) infection [[1]Mori G. Morrison M. Blumenthal A. Microbiome-immune interactions tuberculosis.PLOS Pathog. 2021; 17e1009377https://doi.org/10.1371/journal.ppat.1009377Crossref PubMed Scopus (4) Google Scholar,[2]Namasivayam S. Maiga Yuan W. Thovarai V. Costa D.L. Mittereder L.R. et al.Longitudinal profiling reveals persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy.Microbiome. 2017; 5: 71https://doi.org/10.1186/s40168-017-0286-2Crossref (58) Scholar]. TB is one most fatal infectious disease caused Mycobacterium complex remains major cause global morbidity mortality [[3]Kone B. Somboro A.M. Holl J.L. Baya Togo A.A. Sarro Y.D.S. al.Exploring usefulness molecular epidemiology Africa: systematic review.Int J Mol Epidemiol Genet. 2020; 11: 1-15PubMed associated metabolites likely to play role susceptibility progression severity disease. Changes structure populations could impact immunity signaling. Gaining an in-depth understanding parameters relationship reveal key-elements predict modulate progression, severity, treatment outcomes and, possibly re-infection. inflammation mostly described capacity certain produce specific enzymes ferment nutrients into absorbable forms, such carbohydrates form short-chain fatty acids (SCFAs) possess anti-inflammatory immunomodulatory properties [[4]Eribo O.A. du Plessis N. Ozturk Guler R. Walzl Chegou N.N. response: guilty or not guilty?.Cell Life Sci. 77: 1497-1509Crossref (12) Moreover, other components microbes like cell capsule carbohydrates, lipopolysaccharides, endotoxins, produced maintain integrity wall, intervene production vitamins, regulation endocrine hormones, energy activation, stimulation inhibition key immune system signaling molecules [[5]Venegas D.P. De La Fuente M.K. Landskron González M.J. Quera Dijkstra al.Short chain (SCFAs)mediated epithelial relevance for inflammatory bowel diseases.Front Immunol. 2019; 10: 277https://doi.org/10.3389/fimmu.2019.00277Crossref (584) Therefore, interaction between affect response, this lead either path regulatory cells pro-inflammation. On hand, microbiota drug metabolism provide protection against pathogenic organisms through colonization competition resources. SCFAs, propionate, butyrate, acetate, lactate microbiome. They interact with G protein-coupled receptors induce responses via signal transduction pathways. mitogen-activated kinases (MAPK) pathway involved pro-inflammatory response while beta-arrestin-2 response. SCFAs bind their stimulate IL-10 secretion from dendritic macrophages innate immunity. For adaptive promote expansion T (Treg) B gut-lung axis Scholar], all which overall balance modulation Initial findings suggested alterations [6Hu Y. Feng Wu J. Liu F. Zhang Z. Hao al.The signatures discriminate pulmonary patients.Front Cell Infect Microbiol. 9https://doi.org/10.3389/fcimb.2019.00090Crossref (41) Scholar, 7Li Zhu Liao Q. Wang Wan C. Characterization children tuberculosis.BMC Pediatr. https://doi.org/10.1186/s12887-019-1782-2Crossref (11) 8Namasivayam Diarra Diabate Kone al.Patients infected africanum versus distinct microbiota.PLoS Negl Trop Dis. 14e0008230Crossref found significant decrease diversity fecal samples patients compared controls. In issue, Naidoo al. different compartments, using oral wash, induced sputum, stool symptomatic cases, no-TB controls, household contacts previous two performed peripheral blood transcriptome comparative analysis. This represents first study, date, comprehensive thoughtful selection control reduce maximum bias. study also linked changes phenotype during TB. authors identified profile cases close contacts, Erysipelotrichaceae, Blautia, Anaerostipes stool, precursor inferred pathways short known [[9]Naidoo C.C. Nyawo G.R. Sulaiman I. B.G. Turner C.T. Bu K. al.Anaerobe-enriched predicts tuberculosis.EBioMedicine. 67103374https://doi.org/10.1016/j.ebiom.2021.103374Summary Full Text PDF (2) enriched anaerobes upregulation related microbiome-transcriptome network were contacts. Also, anaerobes, Paludibacter, Lautropia washes sputum. Overall convincingly shows microbiome-inflammation pattern unique group, clearly demonstrates microbial-related has been conditions, cancer, certainly new avenues research on biomarkers microbiome-targeted prevention adjuvant treatments. earlier Namasivayam order Clostridiales phylum Firmicutes members Tenericutes mouse model [[2]Namasivayam similar observations made Hu [[10]Hu Yang Dong Sun L. al.Gut drugs.J Infect. 78: 317-322Summary (27) These commensals highlights some mechanistic differences humans mice, outcome similarities, It now evident community metabolic considerably controls Scholar,[10]Hu differential abundance serve biosignatures active individuals potentially used therapeutic target immunomodulator regimens nutritional severe [[6]Hu Probiotics, prebiotics, transfer strategies potential options interventions. All contributed Conceptualization (AMS, DD, JLH MM), data curation DD formal analysis funding aquisition (AMS investigation methodology Resources (MM), Supervision validation visualization Writing original draft writing review editing MM). There no conflicts interest. work was supported National Institutes Health ( R21AI148033 D43TW010543 ). Anaerobe-enriched tuberculosisTB-specific relationships washes, before confounding effects antibiotics. Specific cases' immunological pathways, supporting microbiota's Full-Text Open Access

Язык: Английский

The Interplay between Mycobacterium tuberculosis and Human Microbiome DOI Creative Commons
Michelle Nguyen,

Phillip Ahn,

John Dawi

и другие.

Clinics and Practice, Год журнала: 2024, Номер 14(1), С. 198 - 213

Опубликована: Янв. 24, 2024

Tuberculosis (TB), a respiratory disease caused by Mycobacterium tuberculosis (Mtb), is significant cause of mortality worldwide. The lung, breeding ground for Mtb, was once thought to be sterile environment, but has now been found host its own profile microbes. These microbes are critical in the development immune system and can produce metabolites that aid defense against various pathogens. Mtb infection as well antibiotics shift microbial profile, causing dysbiosis dampening response. Additionally, increasing cases drug resistant TB have impacted success rates traditional therapies isoniazid, rifampin, pyrazinamide, ethambutol. Recent years produced tremendous research into human microbiome role contributing or attenuating processes. Potential treatments aimed at altering gut-lung bacterial axis may offer promising results help mitigate effects TB.

Язык: Английский

Процитировано

1
Full-length 16S rDNA sequencing based on Oxford Nanopore Technologies revealed the association between gut-pharyngeal microbiota and tuberculosis in cynomolgus macaques DOI Creative Commons
Vorthon Sawaswong, Prangwalai Chanchaem, Pavit Klomkliew

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 10, 2024

Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis complex (Mtbc), which develops from asymptomatic latent TB to active stages. The microbiome was purposed as a potential factor affecting pathogenesis, but study limited. present explored association between gut-pharyngeal and stages in cynomolgus macaques using full-length 16S rDNA amplicon sequencing based on Oxford Nanopore Technologies. total of 71 divided into (-) control, (+) groups. differential abundance analysis showed that Haemophilus hemolyticus decreased, while Prevotella species were increased pharyngeal macaques. In addition, Eubacterium coprostanoligenes gut enriched Alteration these bacteria might affect immune regulation severity, details mechanisms should be further validated. summary, microbiota may associated with host progression. findings suggested host-microbes interaction, improve understanding role help develop therapeutics for future.

Язык: Английский

Процитировано

1
Bad company? The pericardium microbiome in people investigated for tuberculosis pericarditis in an HIV-prevalent setting DOI Open Access
Georgina Nyawo, C Naidoo, Benjamin G. Wu

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 27, 2024

Abstract Background The microbiome likely plays a role in tuberculosis (TB) pathogenesis. We evaluated the site-of-disease and predicted metagenome people with presumptive tuberculous pericarditis, major cause of mortality, explored for first time, interaction between its association C-reactive protein (CRP), potential diagnostic biomarker extrapulmonary TB. Methods People effusions requiring pericardiocentesis (n=139) provided background sampling controls pericardial fluid (PF) 16S rRNA gene sequencing analysed using QIIME2 PICRUSt2. Blood was collected to measure CRP. Results PF from definite (dTB, n=91), probable (pTB, n=25), non- (nTB, n=23) pericarditis differed β-diversity. dTBs were, vs. nTBs, Mycobacterium-, Lacticigenium-, Kocuria- enriched. Within dTBs, HIV-positives were Bifidobacterium- , Methylobacterium- Leptothrix -enriched HIV-negatives HIV-positive on ART Mycobacterium - Bifidobacterium -depleted those not ART. Compared exhibited short-chain fatty acid (SCFA) mycobacterial metabolism microbial pathway enrichment. additional non-pericardial involvement had differentially taxa (e.g., -enrichment Streptococcus -depletion associated pulmonary infiltrates). reads 34% (31/91), 8% (2/25) 17% (4/23) pTBs, respectively. β-diversity patients CRP above below median value ( Pseudomonas -depleted). There no correlation enriched Conclusions is compositionally distinct based TB status, HIV (and ART) status are SCFA-associated taxa. clinical significance these findings, including nTBs requires evaluation.

Язык: Английский

Процитировано

1
Urbanization and Infectious Disease DOI
Achsah F. Dorsey

American Journal of Human Biology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

ABSTRACT The United Nations currently estimates that over half of the global population has lived in cities since 2017 and this proportion is continuing to grow, particularly Global South. While urbanization not new, increased density combined with accelerating rates (re)emerging noncommunicable diseases as well growing economic disparities created new challenges human health well‐being. Here, I examine peri‐urban communities, peripheral settlements on edges urban areas populated by rural people, argue these are often overlooked, despite becoming increasingly common. Thus, biologists should move beyond categorizing spaces transitional. Using unplanned, communities around Lima, Peru a case study, detail complexity political ecological factors impact infectious disease risk communities. mechanisms, demonstrate importance biocultural approach ecology perspective when investigating disease. highlight how anthropologists uniquely positioned explore heterogeneity patterns pathways an urbanized world.

Язык: Английский

Процитировано

1
The role of the microbiome in inflammation during tuberculosis DOI Creative Commons
Anou M. Somboro, Dramane Diallo, Jane L. Holl

и другие.

EBioMedicine, Год журнала: 2021, Номер 68, С. 103435 - 103435

Опубликована: Июнь 1, 2021

The human gut microbiota, comprised of a diverse microbial ecosystem, consists hundreds groups species that are relatively stable in healthy individuals, but its composition can change rapidly as result illness, age, diet, antibiotic use, host genetics, and inflammation. Recent reports have shown the microbiome may be implicated tuberculosis (TB) infection [[1]Mori G. Morrison M. Blumenthal A. Microbiome-immune interactions tuberculosis.PLOS Pathog. 2021; 17e1009377https://doi.org/10.1371/journal.ppat.1009377Crossref PubMed Scopus (4) Google Scholar,[2]Namasivayam S. Maiga Yuan W. Thovarai V. Costa D.L. Mittereder L.R. et al.Longitudinal profiling reveals persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy.Microbiome. 2017; 5: 71https://doi.org/10.1186/s40168-017-0286-2Crossref (58) Scholar]. TB is one most fatal infectious disease caused Mycobacterium complex remains major cause global morbidity mortality [[3]Kone B. Somboro A.M. Holl J.L. Baya Togo A.A. Sarro Y.D.S. al.Exploring usefulness molecular epidemiology Africa: systematic review.Int J Mol Epidemiol Genet. 2020; 11: 1-15PubMed associated metabolites likely to play role susceptibility progression severity disease. Changes structure populations could impact immunity signaling. Gaining an in-depth understanding parameters relationship reveal key-elements predict modulate progression, severity, treatment outcomes and, possibly re-infection. inflammation mostly described capacity certain produce specific enzymes ferment nutrients into absorbable forms, such carbohydrates form short-chain fatty acids (SCFAs) possess anti-inflammatory immunomodulatory properties [[4]Eribo O.A. du Plessis N. Ozturk Guler R. Walzl Chegou N.N. response: guilty or not guilty?.Cell Life Sci. 77: 1497-1509Crossref (12) Moreover, other components microbes like cell capsule carbohydrates, lipopolysaccharides, endotoxins, produced maintain integrity wall, intervene production vitamins, regulation endocrine hormones, energy activation, stimulation inhibition key immune system signaling molecules [[5]Venegas D.P. De La Fuente M.K. Landskron González M.J. Quera Dijkstra al.Short chain (SCFAs)mediated epithelial relevance for inflammatory bowel diseases.Front Immunol. 2019; 10: 277https://doi.org/10.3389/fimmu.2019.00277Crossref (584) Therefore, interaction between affect response, this lead either path regulatory cells pro-inflammation. On hand, microbiota drug metabolism provide protection against pathogenic organisms through colonization competition resources. SCFAs, propionate, butyrate, acetate, lactate microbiome. They interact with G protein-coupled receptors induce responses via signal transduction pathways. mitogen-activated kinases (MAPK) pathway involved pro-inflammatory response while beta-arrestin-2 response. SCFAs bind their stimulate IL-10 secretion from dendritic macrophages innate immunity. For adaptive promote expansion T (Treg) B gut-lung axis Scholar], all which overall balance modulation Initial findings suggested alterations [6Hu Y. Feng Wu J. Liu F. Zhang Z. Hao al.The signatures discriminate pulmonary patients.Front Cell Infect Microbiol. 9https://doi.org/10.3389/fcimb.2019.00090Crossref (41) Scholar, 7Li Zhu Liao Q. Wang Wan C. Characterization children tuberculosis.BMC Pediatr. https://doi.org/10.1186/s12887-019-1782-2Crossref (11) 8Namasivayam Diarra Diabate Kone al.Patients infected africanum versus distinct microbiota.PLoS Negl Trop Dis. 14e0008230Crossref found significant decrease diversity fecal samples patients compared controls. In issue, Naidoo al. different compartments, using oral wash, induced sputum, stool symptomatic cases, no-TB controls, household contacts previous two performed peripheral blood transcriptome comparative analysis. This represents first study, date, comprehensive thoughtful selection control reduce maximum bias. study also linked changes phenotype during TB. authors identified profile cases close contacts, Erysipelotrichaceae, Blautia, Anaerostipes stool, precursor inferred pathways short known [[9]Naidoo C.C. Nyawo G.R. Sulaiman I. B.G. Turner C.T. Bu K. al.Anaerobe-enriched predicts tuberculosis.EBioMedicine. 67103374https://doi.org/10.1016/j.ebiom.2021.103374Summary Full Text PDF (2) enriched anaerobes upregulation related microbiome-transcriptome network were contacts. Also, anaerobes, Paludibacter, Lautropia washes sputum. Overall convincingly shows microbiome-inflammation pattern unique group, clearly demonstrates microbial-related has been conditions, cancer, certainly new avenues research on biomarkers microbiome-targeted prevention adjuvant treatments. earlier Namasivayam order Clostridiales phylum Firmicutes members Tenericutes mouse model [[2]Namasivayam similar observations made Hu [[10]Hu Yang Dong Sun L. al.Gut drugs.J Infect. 78: 317-322Summary (27) These commensals highlights some mechanistic differences humans mice, outcome similarities, It now evident community metabolic considerably controls Scholar,[10]Hu differential abundance serve biosignatures active individuals potentially used therapeutic target immunomodulator regimens nutritional severe [[6]Hu Probiotics, prebiotics, transfer strategies potential options interventions. All contributed Conceptualization (AMS, DD, JLH MM), data curation DD formal analysis funding aquisition (AMS investigation methodology Resources (MM), Supervision validation visualization Writing original draft writing review editing MM). There no conflicts interest. work was supported National Institutes Health ( R21AI148033 D43TW010543 ). Anaerobe-enriched tuberculosisTB-specific relationships washes, before confounding effects antibiotics. Specific cases' immunological pathways, supporting microbiota's Full-Text Open Access

Язык: Английский

Процитировано

9