ACS Infectious Diseases,
Год журнала:
2024,
Номер
10(5), С. 1431 - 1457
Опубликована: Апрель 29, 2024
Mucormycosis,
a
rare
but
deadly
fungal
infection,
was
an
epidemic
during
the
COVID-19
pandemic.
The
rise
in
cases
(COVID-19-associated
mucormycosis,
CAM)
is
attributed
to
excessive
steroid
and
antibiotic
use,
poor
hospital
hygiene,
crowded
settings.
Major
contributing
factors
include
diabetes
weakened
immune
systems.
main
manifesting
forms
of
CAM─cutaneous,
pulmonary,
deadliest,
rhinocerebral─and
disseminated
infections
elevated
mortality
rates
85%.
Recent
focus
lies
on
small-molecule
inhibitors
due
their
advantages
over
standard
treatments
like
surgery
liposomal
amphotericin
B
(which
carry
several
long-term
adverse
effects),
offering
potential
central
nervous
system
penetration,
diverse
targets,
simpler
dosing
owing
small
size,
rendering
ability
traverse
blood–brain
barrier
via
passive
diffusion
facilitated
by
phospholipid
membrane.
Adaptation
versatility
mucormycosis
are
multitude
virulence
factors,
enabling
pathogen
dynamically
respond
various
environmental
stressors.
A
comprehensive
understanding
these
mechanisms
imperative
for
devising
effective
therapeutic
interventions
against
this
highly
opportunistic
that
thrives
immunocompromised
individuals
through
its
angio-invasive
nature.
Hence,
Review
delineates
principal
it
employs
persist
challenging
host
environments,
current
progress
developing
them.
Infectious Disorders - Drug Targets,
Год журнала:
2023,
Номер
24(1)
Опубликована: Авг. 23, 2023
Mucormycosis
is
a
serious
and
invasive
fungal
infection
caused
by
Mucorales
fungi.
This
review
article
provides
concise
overview
of
the
pathogenesis,
epidemiology,
microbiology,
diagnosis
mucormycosis.
The
introduction
section
highlights
key
microbiological
properties
pathogen
delves
into
underlying
mechanisms
mucormycosis
including
invasion
proliferation
fungus
within
host.
description
disease
focuses
on
epidemiology
mucormycosis,
its
incidence,
risk
factors,
geographical
distribution.
It
also
explores
specific
context
about
COVID-19
diabetes
mellitus,
highlighting
increased
susceptibility
observed
in
individuals
with
these
conditions.
A
case
study
illustrates
clinical
manifestations
challenges
associated
emphasizing
importance
early
detection.
Additionally,
discusses
significance
assessment,
radiological
imaging,
tests
for
accurate
timely
detection
infection.
Regarding
treatment,
covers
various
therapeutic
approaches,
antifungal
therapy,
surgical
interventions,
management
predisposing
limitations
treatment
options
are
addressed.
aims
to
provide
comprehensive
understanding
equipping
healthcare
professionals
valuable
insights
diagnostic
strategies.
By
enhancing
knowledge
awareness
this
infection,
can
improve
patient
outcomes
through
appropriate
management.
Current Opinion in Infectious Diseases,
Год журнала:
2023,
Номер
36(6), С. 427 - 435
Опубликована: Сен. 21, 2023
Purpose
of
review
Mucormycosis
(MCR)
is
a
common
opportunistic
mold
infection,
and
Mucorales
were
recently
designated
by
WHO
as
priority
pathogens.
The
interest
in
this
infection
has
risen
significantly
since
the
major
outbreak
MCR
context
COVID-19
pandemic,
particularly
India.
Herein,
we
summarize
(last
24
months)
published
information
regarding
clinical
aspects
MCR.
Recent
findings
disease
remains
protean
its
presentation,
difficult
to
diagnose,
challenging
treat.
In
2021,
cases
COVID-19-associated
mucormycosis
(CAM)
exploded
India
during
manifested
primarily
sino-orbital
or
sino-cerebral
disease.
Its
classic
risk
factors
included
triad
COVID-19,
uncontrolled
diabetes
mellitus
use
corticosteroids.
Despite
difficulties
timely
diagnosis
MCR,
significant
progress
been
made
with
molecular
techniques
blood
assist
earlier
diagnosis,
which
can
facilitate
appropriate
therapy
improve
outcomes.
addition,
advances
have
imaging
stage
disease,
determining
what
types
multimodal
are
required
depending
on
staging,
tissue-based
identification
Mucorales.
Summary
Although
outlook
for
improved,
effective
new
antifungals,
stratification,
optimal
multimodality
approaches
remain
an
unmet
need.
Journal of Fungi,
Год журнала:
2024,
Номер
10(1), С. 85 - 85
Опубликована: Янв. 22, 2024
Mucormycosis
presents
a
formidable
challenge
to
clinicians
and
researchers.
Animal
models
are
an
essential
part
of
the
effort
decipher
pathogenesis
mucormycosis
develop
novel
pharmacotherapeutics
against
it.
Diverse
model
systems
have
been
established,
using
range
animal
hosts,
immune
metabolic
perturbations,
infection
routes.
An
understanding
characteristics,
strengths,
drawbacks
these
is
needed
optimize
their
use
for
specific
research
aims.
Brazilian Journal of Health Review,
Год журнала:
2024,
Номер
7(1), С. 5008 - 5021
Опубликована: Фев. 8, 2024
Este
artigo
explora
a
relação
entre
diabetes
mellitus,
uma
doença
crônica
que
afeta
milhões
de
pessoas
no
mundo,
e
as
infecções
microbianas,
causadas
por
diferentes
tipos
micro-organismos.
O
objetivo
é
apresentar
correlação
mellitus
os
agentes
invasores,
ressaltando
importância
da
saúde
pública.
A
metodologia
consiste
em
pesquisa
bibliográfica,
revisou
artigos
científicos
publicados
periódicos
nacionais
internacionais.
Os
resultados
mostram
está
associada
maior
frequência,
severidade
recorrência
bacterianas,
fúngicas,
parasitárias
virais,
podem
comprometer
diversos
órgãos
sistemas
do
corpo.
As
microbianas
também
piorar
o
controle
glicêmico
progressão
mellitus.
conclusões
apontam
um
fator
agravante
para
necessário
desenvolver
estratégias
preventivas
terapêuticas
específicas
essa
população
vulnerável.
sugere
mais
pesquisas
sejam
feitas
compreender
mecanismos
moleculares
celulares
envolvidos
na
interação
microbianas.
ACS Infectious Diseases,
Год журнала:
2024,
Номер
10(5), С. 1431 - 1457
Опубликована: Апрель 29, 2024
Mucormycosis,
a
rare
but
deadly
fungal
infection,
was
an
epidemic
during
the
COVID-19
pandemic.
The
rise
in
cases
(COVID-19-associated
mucormycosis,
CAM)
is
attributed
to
excessive
steroid
and
antibiotic
use,
poor
hospital
hygiene,
crowded
settings.
Major
contributing
factors
include
diabetes
weakened
immune
systems.
main
manifesting
forms
of
CAM─cutaneous,
pulmonary,
deadliest,
rhinocerebral─and
disseminated
infections
elevated
mortality
rates
85%.
Recent
focus
lies
on
small-molecule
inhibitors
due
their
advantages
over
standard
treatments
like
surgery
liposomal
amphotericin
B
(which
carry
several
long-term
adverse
effects),
offering
potential
central
nervous
system
penetration,
diverse
targets,
simpler
dosing
owing
small
size,
rendering
ability
traverse
blood–brain
barrier
via
passive
diffusion
facilitated
by
phospholipid
membrane.
Adaptation
versatility
mucormycosis
are
multitude
virulence
factors,
enabling
pathogen
dynamically
respond
various
environmental
stressors.
A
comprehensive
understanding
these
mechanisms
imperative
for
devising
effective
therapeutic
interventions
against
this
highly
opportunistic
that
thrives
immunocompromised
individuals
through
its
angio-invasive
nature.
Hence,
Review
delineates
principal
it
employs
persist
challenging
host
environments,
current
progress
developing
them.
