The Covid-19 and TB Syndemic: Differences and Similarities DOI Open Access
Stefan H. E. Kaufmann, Alan Sher, Alex Sigal

и другие.

Frontiers research topics, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

it is a pioneering approach to the world of academia, radically improving way scholarly research managed.The grand vision Frontiers where all people have an equal opportunity seek, share and generate knowledge.Frontiers provides immediate permanent online open access its publications, but this alone not enough realize our goals. journal seriesThe series multi-tier interdisciplinary set openaccess, journals, promising paradigm shift from current review, selection dissemination processes in academic publishing.All journals are driven by researchers for researchers; therefore, they constitute service community.At same time, operates on revolutionary invention, tiered publishing system, initially addressing specific communities scholars, gradually climbing up broader public understanding, thus serving interests lay society, too. Dedication qualityEach article landmark highest quality, thanks genuinely collaborative interactions between authors review editors, who include some world's best academicians.Research must be certified peers before entering stream knowledge that may eventually reach -and shape society; only applies most rigorous unbiased reviews.Frontiers revolutionizes freely delivering outstanding research, evaluated with no bias both social point view.By applying advanced information technologies, catapulting into new generation.

Язык: Английский

Integrating genetic and immune factors to uncover pathogenetic mechanisms of viral-associated pulmonary aspergillosis DOI Creative Commons
Samuel M. Gonçalves, Inês M. Pereira, Simon Feys

и другие.

mBio, Год журнала: 2024, Номер 15(6)

Опубликована: Апрель 23, 2024

Invasive pulmonary aspergillosis is a severe fungal infection primarily affecting immunocompromised patients. Individuals with viral infections have recently been identified as vulnerable to developing invasive infections. Both influenza-associated (IAPA) and COVID-19-associated (CAPA) are linked high mortality rates, emphasizing the urgent need for an improved understanding of disease pathogenesis unveil new molecular targets diagnostic therapeutic potential. The recent establishment animal models replicating co-infection context has offered crucial insights into mechanisms that underlie susceptibility disease. However, development progression human viral-fungal co-infections exhibit significant degree interindividual variability, even among patients similar clinical conditions. This observation implies role host genetics, but information regarding genetic basis currently limited. In this review, we discuss how factors known affect either antiviral or antifungal immunity could potentially reveal pathogenetic predispose IAPA CAPA influence overall course. These anticipated foster further research in both pre-clinical patients, aiming elucidate complex pathophysiology viral-associated contributing identification improve management these co-infections.

Язык: Английский

Процитировано

7
Recent developments in Aspergillus fumigatus research: diversity, drugs, and disease DOI
Nicole Kordana, Angus Johnson, Karen Quinn

и другие.

Microbiology and Molecular Biology Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

SUMMARY Advances in modern medical therapies for many previously intractable human diseases have improved patient outcomes. However, successful disease treatment outcomes are often prevented due to invasive fungal infections caused by the environmental mold Aspergillus fumigatus . As contemporary antifungal not experienced same robust advances as other therapies, defining mechanisms of A. initiation and progression remains a critical research priority. To this end, World Health Organization recently identified priority pathogen Centers Disease Control has highlighted emergence triazole-resistant isolates. The expansion diversity host populations susceptible aspergillosis complex dynamic genotypic phenotypic call reinvigorated assessment pathobiological drug-susceptibility mechanisms. Here, we summarize recent advancements field discuss challenges our understanding heterogeneity its pathogenesis diverse populations.

Язык: Английский

Процитировано

1
Co-infection of mice with SARS-CoV-2 and Mycobacterium tuberculosis limits early viral replication but does not affect mycobacterial loads DOI Creative Commons
Paul J. Baker, Eduardo P. Amaral, Ehydel Castro

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Сен. 1, 2023

Viral co-infections have been implicated in worsening tuberculosis (TB) and during the COVID-19 pandemic, global rate of TB-related deaths has increased for first time over a decade. We others previously shown that resolved prior or concurrent influenza A virus infection

Язык: Английский

Процитировано

14
Nuclear receptor 4A1 is critical for neutrophil-dependent pulmonary immunity to Klebsiella pneumoniae infection DOI Creative Commons
Norie Sugitani,

Matthew Henkel,

Jessica Partyka

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 6, 2025

Introduction Bacterial pneumonia is a burdensome, costly disease and increasingly challenging to treat due antibiotic resistance. Complex host-pathogen interactions regulate protective immunity. Neutrophils play central role in pulmonary bacterial immunity, mechanistic understanding of neutrophil functions has potential clinical fundamental application. Nuclear receptor 4a1 (Nr4a1), member the nuclear orphan family, been described inflammation immune development cell type-specific manner, but its host defense not well understood. Methods Wild-type (WT) Nr4a1 -/- mice, as bone marrow chimeric Gr-1+ antibody depleted were infected with Klebsiella pneumoniae assessed for burden lung spleen, gene transcription, protein levels, histology cellular abundance by flow cytometry lung. WT neutrophils exposed live quantify killing, bulk RNA sequencing assess transcriptomic differences. Results Nr4a1-deficient mice are highly susceptible pneumonia, which was mediated expression cells. depletion ameliorated Nr4a1-dependent phenotype. Ex vivo , had impaired bactericidal capacity, analysis identified an program neutrophils. Discussion Neutrophil critical against K. infection regulating transcriptome. These findings suggest targeting signaling pathways may be useful treatment.

Язык: Английский

Процитировано

0
Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis DOI Creative Commons
Jezreel Pantaleón García, Sebastian Wurster,

Nathaniel D. Albert

и другие.

mBio, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

ABSTRACT Influenza-associated pulmonary aspergillosis (IAPA) is a potentially deadly superinfection in patients with influenza pneumonia, especially those severe disease, underlying immunosuppression, corticosteroid therapy, or requiring intensive care support. Given the high mortality of IAPA, adjunct immunomodulatory strategies remain critical unmet need. Previously, desensitization pattern recognition pathways has been described as hallmark IAPA pathogenesis and predictor patients. Therefore, we studied impact nebulized Toll-like receptor 2/6/9 agonists Pam2 CSK4 (Pam2) CpG oligodeoxynucleotides (ODNs) on infection outcomes immunopathology corticosteroid-immunosuppressed murine model. Mice receiving mock therapy showed rapidly progressing disease paralyzed immune response to secondary Aspergillus fumigatus infection. Nebulized Pam2ODN was well tolerated significantly prolonged event-free survival. Specifically, dual-dose before after A. led 81% survival full recovery all survivors. Additionally, transcriptional analysis lung tissue homogenates revealed induction signaling several key effector cytokine therapy. Moreover, flow cytometric analyses suggested increased frequencies macrophages, natural killer cells, T cells lungs Pam2ODN-treated mice. Collectively, treatment strongly improved morbidity alleviated antifungal immunity an otherwise lethal These findings suggest that might be promising candidate for locally delivered improve virus-associated mold infections such IAPA. IMPORTANCE The COVID-19 pandemic highlighted significant healthcare burden, morbidity, caused by fungal pneumonias. heightened prevalence viral pneumonias, influenza, poor immunotherapies are needed prevent treat infections. We herein demonstrate severely mouse model influenza-associated (IAPA), partially due dysregulated pathogen-sensing pathways. To overcome paralysis progression, used dyad immunomodulators (Toll-like agonists). immunotherapy compared mature mononuclear phagocytes lung, stimulated antimicrobial signaling. this proof-of-concept study demonstrates feasibility efficacy alleviate virus-induced dysregulation post-viral pneumonias

Язык: Английский

Процитировано

0
Fungal pathogens and COVID-19 DOI
Ashutosh Singh, Amtoj Kaur, Anuradha Chowdhary

и другие.

Current Opinion in Microbiology, Год журнала: 2023, Номер 75, С. 102365 - 102365

Опубликована: Авг. 23, 2023

Язык: Английский

Процитировано

5
Invasive pulmonary aspergillosis following human metapneumovirus infection in solid‐organ transplant recipients: Another virus to add to the list DOI

Isabel Cristina Ramírez‐Sánchez,

Ricardo Augusto Diaz‐Sanabria, Jhongert Alza‐Arcila

и другие.

Transplant Infectious Disease, Год журнала: 2023, Номер 26(1)

Опубликована: Ноя. 8, 2023

Abstract There is increasing recognition that respiratory viral infections such as influenza, syncytial virus, parainfluenza adenovirus, and SARS‐CoV‐2 can promote the development of invasive fungal pulmonary coinfections, particularly aspergillosis, both in immunocompetent immunocompromised patients. To date, there are no case reports exploring role human metapneumovirus a risk factor for coinfection. Below, we describe 63‐year‐old woman who received kidney transplant developed aspergillosis after infection discuss possible phenomena could favor this association

Язык: Английский

Процитировано

1
Determinant of 30-day Mortality of Pulmonary Legionellosis: Do Co-Infections Matter? DOI Creative Commons
Takahiro Matsuo, Sebastian Wurster, Ying Jiang

и другие.

Open Forum Infectious Diseases, Год журнала: 2024, Номер 11(9)

Опубликована: Авг. 30, 2024

Abstract We retrospectively reviewed 64 cases of cancer with pulmonary legionellosis (Legionella pneumophila in 73%). Nearly all patients received Legionella-active antibiotics, yet 30-day mortality was 23%. Independent predictors were hyponatremia, bilateral lung involvement, and Sequential Organ Failure Assessment score ≥5. Lung coinfections common (31%) but did not significantly increase mortality.

Язык: Английский

Процитировано

0
Developing a Coccidioides posadasii and SARS-CoV-2 Co-infection Model in the K18-hACE2 Transgenic Mouse DOI Creative Commons
Daniel R. Kollath, Francisca J. Grill,

Ashley N. Itogawa

и другие.

Communications Medicine, Год журнала: 2024, Номер 4(1)

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

0
Contextual influence of mammalian macro-autophagy in virus-bacteria coinfected cell phenotypes DOI Creative Commons
Christophe Viret,

Aude Lavedrine,

Guénaëlle Lamiral

и другие.

PLoS Pathogens, Год журнала: 2023, Номер 19(9), С. e1011625 - e1011625

Опубликована: Сен. 21, 2023

HAL is

Язык: Английский

Процитировано

0