TRIM proteins: A ‘swiss army knife’ of antiviral immunity

PLoS Pathogens, Год журнала: 2025, Номер 21(5), С. e1013147 - e1013147

Опубликована: Май 12, 2025

With their modular structure and E3 ubiquitin ligase activity, Tripartite motif (TRIM) proteins interact with a wide range of cellular viral substrates. This review summarizes how they have emerged as key players in the antiviral response. Shortly, TRIM were shown (i) to enhance pro-inflammatory cytokines production by interacting pattern recognition receptors downstream components immune signaling pathways, (ii) interfere trafficking cytoskeleton, (iii) exhibit direct effects targeting for proteasomal degradation or inducing autophagy. combination actions underscores TRIMs potent innate defense system, but also makes them vulnerable evasion strategies.

Язык: Английский

Cellular Takeover: How New World Alphaviruses Impact Host Organelle Function

Virology, Год журнала: 2024, Номер 603, С. 110365 - 110365

Опубликована: Дек. 20, 2024

Язык: Английский