Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts DOI Creative Commons
Marhiah C. Montoya,

Kayla Wilhoit,

Debra Murray

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Classified as a critical public health threat by the World Health Organization, Cryptococcus neo-formans infections with significant morbidity and mortality. Reports of cryptococcosis persistence, relapse, reinfection date back to 1950s, yet factors driving chronic remain poorly understood. A major challenge is scarcity serial patient specimens detailed medical records study simultaneous evolution pathogen host status. This provides first genomic phenotypic analysis in-host C. neoformans during lasting over year in six immunocompromised patients. We find fungal genome persistent infection characterized large-scale restructuring increasing heterogeneity. Phenotypic changes show diversification virulence traits antifungal susceptibility. Genotypically phenotypically distinct sub-lineages arise co-persist within same tissues, consistent model diversifying selection niche partitioning complex environment human hosts.

Язык: Английский

Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts DOI Creative Commons
Marhiah C. Montoya,

Kayla Wilhoit,

Debra Murray

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Classified as a critical public health threat by the World Health Organization, Cryptococcus neo-formans infections with significant morbidity and mortality. Reports of cryptococcosis persistence, relapse, reinfection date back to 1950s, yet factors driving chronic remain poorly understood. A major challenge is scarcity serial patient specimens detailed medical records study simultaneous evolution pathogen host status. This provides first genomic phenotypic analysis in-host C. neoformans during lasting over year in six immunocompromised patients. We find fungal genome persistent infection characterized large-scale restructuring increasing heterogeneity. Phenotypic changes show diversification virulence traits antifungal susceptibility. Genotypically phenotypically distinct sub-lineages arise co-persist within same tissues, consistent model diversifying selection niche partitioning complex environment human hosts.

Язык: Английский

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