How human papillomavirus (HPV) targets DNA repair pathways for viral replication: from guardian to accomplice

Microbiology and Molecular Biology Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

SUMMARY Human papillomaviruses (HPVs) are small DNA viruses that responsible for significant disease burdens worldwide, including cancers of the cervix, anogenital tract, and oropharynx. HPVs infect stratified epithelia at a variety body locations link their productive life cycles to differentiation host cell. These have evolved sophisticated mechanisms exploit cellular pathways, such as damage repair (DDR), regulate cycles. activate key DDR pathways ATM, ATR, FA, which critical maintaining genomic integrity but often dysregulated in cancers. Importantly, these essential HPV replication undifferentiated cells amplification upon differentiation. The ability modulate not only enables persistence also contributes transformation. In this review, we discuss recent advances understanding by manipulates how depend enhanced topoisomerase activity R-loop formation. Furthermore, strategies manipulate utilized high-risk compared with those used other exhibit similarities distinct differences.

Язык: Английский

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Protective role of ghrelin against 6PPD-quinone-induced neurotoxicity in zebrafish larvae (Danio rerio) via the GHSR pathway

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 285, С. 117031 - 117031

Опубликована: Сен. 28, 2024

Язык: Английский

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Regulation of R-Loops in DNA Tumor Viruses

Pathogens, Год журнала: 2024, Номер 13(10), С. 863 - 863

Опубликована: Окт. 2, 2024

R-loops are triple-stranded nucleic acid structures that occur when newly synthesized single-stranded RNA anneals to duplex DNA upon the collision of replication forks with transcription complexes. These RNA-DNA hybrids facilitate several transcriptional processes in cell and have been described extensively literature. Recently, evidence has emerged key regulators tumor virus their lifecycle. Studies demonstrated on Human Papillomavirus (HPV) genome must be resolved maintain maintenance avoid viral integration, a hallmark HPV cancers. For Epstein-Barr (EBV), formed at

Язык: Английский

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The roles of DNA damage repair and innate immune surveillance pathways in HPV pathogenesis

Virology, Год журнала: 2024, Номер 600, С. 110266 - 110266

Опубликована: Окт. 18, 2024

Язык: Английский

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The functions of papillomavirus E2 proteins

Virology, Год журнала: 2024, Номер 603, С. 110387 - 110387

Опубликована: Дек. 31, 2024

Язык: Английский

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