Journal of Fungi, Год журнала: 2025, Номер 11(5), С. 391 - 391

Опубликована: Май 19, 2025

Sclerotinia sclerotiorum is a devastating fungal pathogen that can colonize numerous crops. Despite its economic importance, the regulation of development and pathogenicity remains poorly understood. From forward genetic screen in S. sclerotiorum, six UV mutants were identified with loss-of-function mutations SsATG1, SsATG2, SsATG4, SsATG5, SsATG9, SsATG26. Functional validation through gene knockouts revealed each ATG essential for sclerotia formation, although morphology appressoria was not significantly altered mutants. Different levels virulence attenuation observed among these Autophagy, monitored using GFP-ATG8, showed dynamic activities during development. These findings suggest macroautophagy pexophagy contribute to maturation processes. Future work will reveal how autophagy controls target organelle or protein turnover regulate

Язык: Английский