Therapeutic Potential of Experimental Stereotactic Hippocampal Cell Transplant in the Management of Alzheimer’s Disease
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(3), С. 891 - 891
Опубликована: Янв. 29, 2025
Due
to
a
continuous
increase
in
life
expectancy
and
the
progress
made
specialized
healthcare,
incidence
of
Alzheimer’s
disease
(AD)
has
dramatically
increased
point
that
it
become
one
main
challenges
contemporary
medicine.
Despite
huge
scientific
clinical
effort,
current
treatments
manage
just
temporary
alleviation
symptomatology
but
offer
no
cure.
Modern
trials
involving
cell
transplantation
experimental
animals
require
involvement
neurosurgeons
treatment
protocol.
CSF
shunting,
intraventricular
infusions,
or
DBS
for
symptoms
relief
have
been
an
integral
part
therapeutic
arsenal
from
very
beginning.
The
development
stereotactic
surgery
facilitated
potential
hippocampus
disease.
We
conducted
narrative
review
literature
top
three
medical
databases
(PubMed,
Science
Direct,
Google
Scholar)
using
keywords
“Alzheimer’s
disease”,
“hippocampus”,
“transplant”.
After
eliminating
duplicates,
241
papers
were
selected
screened
by
title
abstract.
Two
reviewers
independently
analyzed
88
chose
32
experiments
involved
hippocampal
cells
with
AD.
such
as
mesenchymal
stem
(MSCs),
neuronal
(NSCs),
induced
pluripotent
(iPSCs),
astrocytes,
derivates
was
analyzed.
used
either
chemically
transgenic
AD
model
observed
impact
behavioral
testing,
MRS
spectroscopy,
biochemical
analysis.
stereotaxic
method
delivers
minimal
invasive
option
at
hippocampus.
results
showed
amyloid
deposits
lower
after
transplantation,
showing
positive
impact.
Other
impactful
involve
proliferation
neurogenesis,
downregulation
anti-inflammatory
response,
plasticity.
precision
which
manages
target
deep
structures
brain
reviewed
could
represent
argument
future
human
trials.
More
studies
are
needed
confirm
viability
transplanted
long-term
effects.
Язык: Английский
Sappanone A mitigates cognitive impairment and oxidative stress through modulation of alpha7 nicotinic acetylcholine receptor in rats with trimethyltin-induced Alzheimer’s disease-like condition
Pharmacological Research - Modern Chinese Medicine,
Год журнала:
2025,
Номер
unknown, С. 100619 - 100619
Опубликована: Апрель 1, 2025
Язык: Английский