Japan‐Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(6), С. 3918 - 3930

Опубликована: Апрель 22, 2024

We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild impairment (MCI).

Язык: Английский

---

An 18‐month multimodal intervention trial for preventing dementia: J‐MINT PRIME Tamba

Alzheimer s & Dementia, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Abstract BACKGROUND The number of people with dementia is increasing in Japan, and establishing evidence for preventing necessary. METHODS This study was a randomized controlled trial cognitively normal community‐dwelling older adults aged 65 to 85 diabetes and/or hypertension. Participants were randomly assigned 1:1 ratio. intervention group underwent 90 min group‐based weekly physical exercise, cognitive training, nutritional counseling, vascular risk management 18 months. primary endpoint the change composite score calculated by averaging z ‐scores seven neuropsychological tests from baseline RESULTS We 203 participants two groups, 178 (87.7%) completed 18‐month follow‐up. There significant difference at months (mean 0.16, 95% confidence interval: 0.04 0.27; p = 0.009). DISCUSSION An multimodal could improve their function. registered Clinical Trial Registration System (UMIN000041938). Highlights Japan‐Multimodal Intervention Prevention Dementia (J‐MINT) PRIME Tamba prevent dementia. provided multifactorial based on Finnish Geriatric Study Prevent Cognitive Impairment Disability (FINGER) methodology. outcome, score, improved our intervention. Executive function/processing speed memory group. adherence high, no serious adverse events occurred.

Язык: Английский

---

The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial

The Journal of Prevention of Alzheimer s Disease, Год журнала: 2021, Номер unknown, С. 1 - 12

Опубликована: Янв. 1, 2021

Язык: Английский

---

Adherence and aerobic exercise intensity in live online exercise sessions for older adults with mild cognitive impairment: Insights from the Japan-Multimodal Intervention Trial for the Prevention of Dementia

Journal of Aging Research and Lifestyle, Год журнала: 2025, Номер 14, С. 100003 - 100003

Опубликована: Янв. 1, 2025

Intervention adherence is crucial to ensure cognitive benefits in trials designed prevent decline. During the coronavirus disease 2019 (COVID-19) pandemic, Japan-Multimodal Trial for Prevention of Dementia offered live online exercise sessions older adults with mild impairment (MCI). To assess and aerobic intensity through MCI. Posthoc analysis 18-month, multi-center, randomized controlled trial. The study was conducted across five institutions Japan. Older aged 65-85 years who were assigned intervention group completed intervention. Participants stratified by region (Aichi Tokyo), where state emergency duration due COVID-19 varied. participated multidomain interventions, including 90-minute group-based physical held weekly 78 sessions. emergency, via video conferencing. Attendance rates (based on heart rates) during onsite compared using Wilcoxon signed-rank test. A total 207 participants analyzed. Over 18 months, conducted, In Aichi region, 2 held, while Tokyo 24 conducted. higher (92 % vs. 86 %, p = 0.046), showed no significant difference (49 52 0.279). No adverse events reported. Live safe, feasible, demonstrated comparable trial registered at University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) November 24, (UMIN000038671) (https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000044075).

Язык: Английский

---

Evaluating the feasibility of a community-adapted multi-domain intervention for dementia prevention in older adults

Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Background Dementia impacts individuals, families, and society, necessitating effective prevention strategies. Objective To evaluate the feasibility of a community-adapted multi-domain intervention for dementia among older adults in Obu City, Japan how uncertainties implementing definitive trials can be reduced. Methods A 12-month one-arm trial was conducted with 80 community-dwelling aged 65–86 years from two district regions. The included physical exercise, nutrition guidance, cognitive training, social participation, vascular risk management. primary outcome continuation rate, defined as proportion participants attending >60% classes initial assessment to 6 months. Secondary outcomes, such fidelity, acceptability, appropriateness, were assessed through qualitative quantitative evaluations. Additionally, health including function overall lifestyle, evaluated. Results study achieved rates 75% 76% at 12 months, respectively, indicating high feasibility. Participants showed program acceptability (average acceptance score, 4.4 5). Fidelity regarding content coverage duration, although frequency varied between sites. Cognitive remained stable; food-diversity status improved significantly over period, though absence control group limits causal interpretation these changes. Conclusions demonstrated adults. Our findings help reduce support planning future effectiveness community-based dementia-prevention programs.

Язык: Английский

---

Factors associated with adherence to tablet‐based cognitive training: J‐MINT study

Alzheimer s & Dementia Translational Research & Clinical Interventions, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 1, 2025

Язык: Английский

---

Adherence and intensity in multimodal lifestyle-based interventions for cognitive decline prevention: state-of-the-art and future directions

Alzheimer s Research & Therapy, Год журнала: 2025, Номер 17(1)

Опубликована: Март 17, 2025

Abstract Preventing dementia and Alzheimer’s disease (AD) is a global priority. Multimodal interventions targeting several risk factors mechanisms simultaneously are currently being tested worldwide under the World-Wide FINGERS (WW-FINGERS) network of clinical trials. Adherence to these crucial for their success, yet there significant heterogeneity in adherence reporting across studies, hindering understanding barriers facilitators. This article narrative review available evidence from multimodal prevention A literature search was conducted using medical databases (MEDLINE via PubMed SCOPUS) select relevant studies: nonpharmacological (i.e., combining three or more intervention domains), individuals without dementia, changes cognitive performance and/or incident mild impairment as primary outcomes. Based on findings, we propose future encompass both participation (average attendance each component) lifestyle change scores (e.g., LIBRA index). Moreover, provide an estimation expected intensity interventions, defined ratio dose overall amount offered specified trial protocol) duration (in months). Adjusting by average enables observed intensity, which could be informative identifying optimal dosage thresholds that maximize benefits different populations. Finally, this provides overview determinants emphasizing need improved inform design implementation precision interventions.

Язык: Английский

---

Longitudinal deterioration of subjective cognitive decline in apolipoprotein ε4 carriers and improvement of subjective cognitive decline by multi-domain intervention for prevention of dementia: The cognitive function instrument assessment

Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Background Subjective cognitive decline represents an early stage of mild impairment, with the Cognitive Function Instrument (CFI) serving to subjectively evaluate in daily living activities associated this minor decline. Objective To examine how CFI scores change apolipoprotein E ε4 (ApoE4) carriage, objective decline, and dementia prevention intervention. We aimed assess CFI's usefulness risk identification. Methods This study involved 196 older adults normal cognition a randomized controlled intervention trial. was assessed every six months from baseline 18 months, using Alzheimer's Disease Cooperative Study-Preclinical Alzheimer Composite (ADCS-PACC) measure employed mixed model for repeated measures compare at ApoE4, ADCS-PACC, allocation groups. Results increased ApoE4 carriers decreased group, significant differences observed score changes between non-carriers among groups (p = 0.002, p 0.026, respectively). However, there no difference ADCS-PACC 0101). Conclusions worsening over time individuals showing tendency deteriorate those These findings suggest that may be able identify high-risk stage. Furthermore, improvement is considered finding when considering future subjective

Язык: Английский

---

Japan-multimodal intervention trial for the prevention of dementia in older people with lifestyle-related diseases: A community-based, 18-month, randomized controlled trial

Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Background The prevalence of Alzheimer's disease is increasing in Japan, highlighting the need to establish evidence-based strategies for its prevention. Objective We aimed evaluate effectiveness a multimodal community-based intervention Japanese older people with lifestyle-related diseases and identify challenges implementing such interventions prevent dementia local communities. Methods An 18-month randomized controlled trial was conducted among individuals aged 65–85 years (hypertension, hyperlipidemia, diabetes, overweight/underweight, smoking), residing single apartment complex. Participants were randomly assigned group (group-based physical exercise, nutritional guidance, management diseases, cognitive training) or control group. primary outcome change composite score derived from seven neuropsychological tests. registered (UMIN000041887: September 24, 2020). Results Of 224 screened individuals, 198 (99 each group), 175 (88.4%) completed assessment. There no significant difference between groups (change test score: 0.25; 95% confidence interval 0.16 0.33 versus 0.29; 0.20 0.38, respectively; p = 0.463). However, subgroup analysis participants mild impairment showed effect on changes logical memory, both immediate ( 0.041) delayed recall tasks 0.043). Conclusions This program demonstrated mitigating decline. Further research needed develop more effective better define target populations.

Язык: Английский

---

Modifiable Risk Factors for Brain Health and Dementia and Opportunities for Intervention: A Brief Review

Clinical Gerontologist, Год журнала: 2022, Номер 46(2), С. 143 - 154

Опубликована: Авг. 22, 2022

Maintaining brain health and promoting healthy lifestyle strategies to manage modifiable risk factors is vital ensuring well-being for all – not only the individuals with memory challenges but also their family caregivers professional providers. In this brief review paper, we highlight protective opportunities dementia reduction (e.g., limited alcohol use reduced exposure air pollution, secondhand smoke, excessive noise); provide an overview of World-Wide FINGERS Network its goal adapt original Finnish Geriatric Intervention Study Prevent Cognitive Impairment Disability (FINGER) multidomain approach in various settings determine whether protocol effective across different populations varied geographic, cultural, economic optimize model a continuum cognitive decline; and, comment on researchers clinicians including intervention primary care need establish linkages multiple levels sustain behavior change prevention, treatment, care.

Язык: Английский

---