Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE): Protocol for a randomized controlled trial (Preprint)

Опубликована: Апрель 19, 2024

Our current understanding of how computerized brain training drives cognitive and functional benefits remains incomplete. This paper describes the protocol for Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE), a randomized controlled trial healthy older adults designed to evaluate whether improves cholinergic signaling. INHANCE evaluates 2 programs alter acetylcholine binding using vesicular transporter ligand [18F] fluoroethoxybenzovesamicol ([18F] FEOBV) positron emission tomography (PET). In this phase IIb, prospective, double-blind, parallel-arm, active-controlled trial, minimum 92 community-dwelling aged 65 years are randomly assigned program principles neuroplasticity (BrainHQ by Posit Science) or an active control computer games entertainment (eg, Solitaire). Both consist 30-minute sessions, 7 times per week 10 weeks (35 total hours), completed remotely at home either loaned personal devices. The primary outcome is change FEOBV anterior cingulate cortex, assessed baseline posttest. Exploratory behavioral outcomes sensitive evaluated before, immediately after, 3 months following intervention assess maintenance observed effects. was funded September 2019. study received approval from Western Institutional Review Board October 2020 with Research Ethics McGill University Centre Canada approvals June 2021. currently ongoing. first participant enrolled July 2021, enrollment closed when 93 participants were December 2023, will conclude 2024. team be unblinded conduct analyses after final exits study. We expect publish results fourth quarter There critical need identify effective scalable nonpharmaceutical interventions enhance cognition adults. contributes our providing potential neurochemical explanation benefit. ClinicalTrials.gov NCT04149457; https://clinicaltrials.gov/ct2/show/NCT04149457 DERR1-10.2196/59705

Язык: Английский

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A Longitudinal Study of CogEvo’s Prediction of Cognitive Decline in Older Adults

Healthcare, Год журнала: 2024, Номер 12(14), С. 1379 - 1379

Опубликована: Июль 10, 2024

The predictive abilities of computer-based screening devices for early cognitive decline (CD) in older adults have rarely been longitudinally examined. Therefore, this study examined the ability CogEvo, a short-duration, device requiring little professional involvement, to predict CD among community-dwelling adults. We determined whether 119 individuals aged ≥ 65 years living Japanese rural communities who scored 24 on Mini-Mental State Examination (MMSE) at baseline developed by annually administering MMSE them. was defined as an score ≤23. At baseline, overall CogEvo judgment grade, with lower grades indicating better function, calculated from results various tasks. Over 2 years, 10 participants CD. Participants 4 had higher percentage cases than those ≤3 (

Язык: Английский

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Title: CITA GO-ON Study. A community based Multidomain Lifestyle Intervention to prevent cognitive decline. Protocol design and study progress

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 11, 2024

BACKGROUND: Accumulating evidence supports the notion that dementia is a multifactorial condition with various risk factors and causes. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) demonstrated lifestyle interventions could confer cognitive benefits. Inspired by this, GOIZ-ZAINDU (GZ) feasibility study adapted FINGER approach Basque context. Building upon GZ study, CITA GO-ON trial aims enhance expand supporting prevention through multidomain intervention of factor management resilience promotion. METHODS: The two-year, population-based, randomized controlled prevent decline in adults aged 60–85 years Cardiovascular Risk Factors, Aging Dementia (CAIDE) score ≥ 6, no dementia, below-than-expected performance on at least one three screening tests. Participants are (1:1) receive either Regular Health Advice (RHA) or Multidomain (MD-Int) encompasses training, socio-emotional skills, multicomponent physical exercise, nutritional culinary intervention, monitoring for cardiovascular risks, pharmacological drug mismanagement, comorbidities. primary outcome efficacy reduce measured global composite z-score modified Neuropsychological Test Battery over two years. secondary outcomes measure cost-effectiveness, quality life, functional abilities. Blood samples brain imaging will also be collected evaluate effects structure plasma biomarkers. RESULTS:From December 2021 January 2024, 980 participants have been enrolled (mean age (standard deviation, SD) 69.40 (6.31), 49.20 % female, mean CAIDE (SD) 7.6 (1.41), MMSE 28.14 (1.92)). Half cohort (n = 451) has already this time, recruitment phase expected concluded fall 2024. final participant complete last visit autumn 2026. CONCLUSION: Study, as part World-Wide FINGERS network, designed validate contribute valuable data inform public health strategies fostering healthy, active aging. Trial registration: was registered ClinicalTrials.gov (NCT04840030) March 26, 2021.

Язык: Английский

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Reduction in the incidence of cognitive impairment and related costs through an innovative health awareness programme in rural Japan

PLoS ONE, Год журнала: 2024, Номер 19(10), С. e0311826 - e0311826

Опубликована: Окт. 14, 2024

Objectives This study examined the impact of Center Healthy Aging Program (CHAP) on cognitive function and economic burden associated with dementia. Methods observational utilised Iwaki cohort data. We included participants mini-mental state examination (MMSE) scores categorised them into pre- post-CHAP groups based their year entry (before 2013 or after) (index year). defined suspected severe impairment mild using MMSE scores, incidence being first observation meeting these definitions during follow-up period. compared rates between Cox proportional hazard analysis. Medical caregiving costs were estimated projected number residents in area sSCI hypothetical 10 years CHAP implemented not compared. Results Of 2,569 participants, 1716 853 groups, respectively. The rate was significantly lower group even after adjusted known factors disorders. No cases occurred Estimated JPY 1,628,450 (USD 11562.00 EUR 10259.24, 100 = USD 0.71 0.63) 789,560 5605.88 4974.23) per person without CHAP, Conclusions demonstrated a reduction among who participated decrease medical impairment.

Язык: Английский

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Interdisciplinary Approaches to Deal with Alzheimer’s Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

Biomedicines, Год журнала: 2022, Номер 10(11), С. 2922 - 2922

Опубликована: Ноя. 14, 2022

Alzheimer's disease is one of the most common neurodegenerative diseases in western population. The incidence this increases with age. Rising life expectancy and resulting increase ratio elderly population are likely to exacerbate socioeconomic problems. a multifactorial disease. In addition amyloidogenic processing leading plaques, tau pathology, but also other molecular causes such as oxidative stress or inflammation play crucial role. We summarize mechanisms which potential interventions known interfere these mechanisms, focusing on nutritional approaches physical activity beneficial effects cognition-oriented treatments focus language communication. Interestingly, recent findings suggest causal link between oral conditions, periodontitis edentulism, disease, raising question whether dental intervention patients can be well. Unfortunately, all previous single-domain have been shown limited benefit patients. However, latest studies indicate that combining efforts into multidomain may increased preventive therapeutic potential. Therefore, another emphasis review, we provide an overview current literature dealing above-mentioned discuss advantages compared monotherapies. Considering options, propose interdisciplinary approach for treatment synergistically links individual approaches. conclusion, review highlights need combine different manner, address future challenges

Язык: Английский

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