Alcohol-associated liver disease—Global epidemiology

Hepatology, Год журнала: 2024, Номер 80(6), С. 1307 - 1322

Опубликована: Апрель 19, 2024

Alcohol-associated liver disease (ALD), as highlighted in this narrative review, is a major public health concern, increasingly impacting global burden and premature mortality. In 2019, ALD accounted for the loss of 11 million life-years worldwide. The rising number deaths disability-adjusted attributed to ALD, particularly pronounced United States, are alarming. Projections suggest that economic impact seen could potentially double by 2040. prevalent among younger adults (20-45 y) has become leading cause transplantation both States Europe. During COVID-19 pandemic, existing trend was further amplified high-risk drinking patterns coincided with rise hospital admissions alcohol-associated hepatitis increased ALD-related prevalence estimated at 3.5% general population, 26.0% hazardous drinkers, 55.1% those alcohol use disorders. Alarmingly, 5-year mortality rates patients exceed 50%, even higher more advanced stages. Methodological challenges, such underreporting, diagnostic difficulties, variability registry data quality, complicate accurate assessment ALD. Additionally, contribution progression other diseases often under acknowledged care registries, significant underestimation its broader implications health. Addressing growing concern requires robust initiatives, heightened awareness, refined techniques, comprehensive epidemiological studies. These measures vital tackle increasing mitigate extensive on individuals systems.

Язык: Английский

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Global Epidemiology of Alcohol-Related Liver Disease, Liver Cancer, and Alcohol Use Disorder, 2000–2021

Clinical and Molecular Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Alcohol represents a leading burden of disease worldwide, including alcohol use disorder (AUD) and alcohol-related liver (ALD). We aim to assess the global AUD, ALD, alcohol-attributable primary cancer between 2000-2021. registered regional trends using data from Global Burden Disease 2021 Study, largest most up-to-date epidemiology database. estimated annual percent change (APC) its 95% confidence interval (CI) changes in age-standardized rates over time. In 2021, there were 111.12 million cases 3.02 132,030 cancer. Between 2000 was 14.66% increase 38.68% 94.12% prevalence. While prevalence rate for increased (APC: 0.59%, [CI] 0.52 0.67%) these years, it decreased ALD -0.71%, CI -0.75 -0.67%) AUD -0.90%, -0.94 -0.86%). There significant variation by region, socioeconomic development level, sex. During last years (2019-2021), prevalence, incidence, death greater extent females. Given high cancer, urgent measures are needed prevent them at both national levels.

Язык: Английский

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Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly

JHEP Reports, Год журнала: 2024, Номер 6(4), С. 101020 - 101020

Опубликована: Янв. 26, 2024

Abstract

Background & Aims

Alcohol-associated liver diseases (ALDs) and alcohol use disorder (AUD) pose a global health risk. AUD is underrecognized in the elderly, burden of complications, including ALD, may increase with aging populations rising intake. However, there lack epidemiological evidence on ALD elderly.

Methods

Using Global Burden Disease Study 2019, we analyzed prevalence, mortality, disability-adjusted life years (DALYs), age-standardized rates (ASRs), temporal change from 2000 to 2019 overall population elderly (65–89 years). The findings were categorized by sex, region, nation, sociodemographic index.

Results

prevalence higher than those adolescents young adults, whereas levels lower adults. In 9.39 million cases (8.69% population) AUD, 3.23 (21.8% alcohol-associated cirrhosis, 68,468 (51.27% cancer among ASRs increased most regions; contrary, death DALYs decreased regions. Nevertheless, many areas.

Conclusions

Our highlighted comparable that population. Public strategies targeting are urgently needed.

Impact implications

disease (ALD) increasing. Advances healthcare education have resulted remarkable spike expectancy consequential aging. little known about epidemiology study indicates increasing population, necessitating early detection, intervention, tailored care unique needs complexities faced older individuals grappling these conditions.

Язык: Английский

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Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Alcohol use disorder (AUD) is a major public health concern and cause of mortality morbidity. Alcohol-associated liver disease (ALD) debilitating complication AUD, mitigated by abstinence from alcohol use. Deep brain stimulation (DBS) emerging as potential treatment for AUD. However, its cost-effectiveness compared to the standard medical unclear. To estimate DBS management patients with AUD ALD. We utilized decision analytic model based on published literature conduct analysis costs outcomes in also carried out threshold determine probability success necessary be cost-effective. Costs were measured 2024 US dollars effectiveness quality-adjusted life years (QALYs). used time horizon 1-2 adopted societal perspective. Our results show that general, not cost-effective at any rate. advanced ALD patients, defined fibrosis stage 3 or beyond becomes For these over two-year period $100,000 willingness-to-pay rates greater than 53%. decompensated one-year rate 35%. Should it prove efficacious, may Thus, future randomized controlled trials evaluate efficacy are warranted.

Язык: Английский

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Alcohol and Hepatocellular Carcinoma

Clinics in Liver Disease, Год журнала: 2024, Номер 28(4), С. 633 - 646

Опубликована: Июль 23, 2024

Язык: Английский

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Liver transplantation for alcohol-associated liver disease: The changing landscape

Hepatology forum/Hepatology forum (Online), Год журнала: 2025, Номер unknown, С. 77 - 86

Опубликована: Янв. 1, 2025

Alcoholic liver disease(ALD) is considered as a growing public health issue with universally increasing disease burden. Various genetic and environmental factors play role in its etiology. ALD recently has become the major indication for Liver Transplantation (LT). Most LT programs select their candidates by adhering to six months of alcohol abstinence policy. Nevertheless, early transplantation (ELT) subject research, both Europe United States, an effective lifesaving option among highly selected severe alcohol-associated hepatitis (SAH) patients. ELT promising way management ALD, perhaps changing clinical practice carefully patient groups.

Язык: Английский

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Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system

Cell Reports, Год журнала: 2025, Номер 44(4), С. 115482 - 115482

Опубликована: Март 29, 2025

Язык: Английский

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Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 16, 2024

ABSTRACT High intensity alcohol drinking during binge episodes overwhelmingly contributes to the socioeconomic burden created by Alcohol Use Disorders (AUD). Novel interventions are needed add current therapeutic toolkit and nociceptin receptor (NOP) antagonists have shown promise in reducing heavy days patients with an AUD. However, endogenous locus of peptide discrete sites NOP action underlying this effect remains understudied. Here we show that lateral septum (LS), a region contributing drinking, is enriched neurons expressing mRNA coding for ( Pnoc) . Pnoc-expressing LS (LS Pnoc ) tuned stimuli associated negative valence display increased excitability withdrawal from binge-like drinking. activation was found aversive qualities also potentiates behavior, suggesting convergence circuitry promotes aversion drives consumption. Viral mediated tracing functional assessment projection fields revealed GABAergic synapses locally within LS, downstream hypothalamus (LH) supramammillary nucleus (SuM). Genetic deletion attenuated intake male mice while LH SuM decrease females. Together, these findings first demonstrate population nociceptin-expressing consumption identifies sex-dependent modulation NOP.

Язык: Английский

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Inadequate Dietary Education and Poor Adherence to a High Protein, Low Sodium Diet in Cirrhosis: Mixed Methods Approach

Digestive Diseases and Sciences, Год журнала: 2024, Номер 69(9), С. 3226 - 3235

Опубликована: Июнь 28, 2024

Язык: Английский

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Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 23, 2024

Abstract Background Alcohol use disorder (AUD) is a major public health concern and cause of mortality morbidity. Alcohol-associated liver disease (ALD) debilitating complication AUD, mitigated by abstinence from alcohol use. Deep brain stimulation (DBS) emerging as potential treatment for AUD. However, its cost-effectiveness compared to the standard medical unclear. Objective To estimate DBS management patients with AUD ALD. Methods We utilized decision analytic model based on published literature conduct analysis costs outcomes in also carried out threshold determine probability success necessary be cost-effective. Costs were measured 2024 US dollars effectiveness quality-adjusted life years (QALYs). used time horizon 1-2 adopted societal perspective. Results Our results show that general, not cost-effective at any rate. advanced ALD patients, defined fibrosis stage 3 or beyond becomes For these over two-year period $100,000 willingness-to-pay rates greater than 53%. decompensated one-year rate 35%. Conclusion Should it prove efficacious, may Thus, future randomized controlled trials evaluate efficacy are warranted.

Язык: Английский

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