Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(1), С. 17 - 17
Опубликована: Янв. 16, 2024
Background:
Cycloheximide
(CXM),
an
antifungal
antibiotic,
causes
impaired
memory
consolidation
as
a
side
effect
partially
by
disturbing
the
activities
of
central
catecholaminergic
and
cholinergic
system.
Some
reports
indicated
that
puerarin
prevented
impairment
in
various
models
rodents.
However,
protective
effects
on
cycloheximide
for
have
not
yet
been
investigated.
Methods:
The
CXM-induced
memory-consolidation
impairment,
produced
administration
AF64A
neurotoxin,
were
investigated
using
passive
avoidance
task
rats.
A
combination
transmitter
receptor
agonists
antagonists
was
used
to
explore
nervous
system
function.
activity
antioxidant
defense
systems
neurotransmitter
prefrontal
cortex
hippocampus
assayed.
Results:
Systemic
(25
50
mg/kg,
i.p.)
or
(5
10
µg/brain,
i.c.v.)
attenuated
1.5
mg/kg
CXM
(s.c.)
improvements
blocked
antagonists,
5-HT2
agonist,
adrenergic
antagonist.
Puerarin
(only
at
reversed
alterations
levels
norepinephrine
monoamines
hippocampus.
also
increased
antioxidant-defense-system
hippocampus,
which
had
decreased
CXM.
Conclusions:
We
suggested
attenuating
may
be
due
decrease
oxidative
damage
normalition
function
Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products,
Год журнала:
2024,
Номер
unknown, С. 1 - 473
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 37
Опубликована: Май 24, 2024
Neurodegenerative
diseases
encompass
a
wide
range
of
debilitating
and
incurable
brain
disorders
characterized
by
the
progressive
deterioration
nervous
system's
structure
function.
Isoflavones,
which
are
naturally
occurring
polyphenolic
phytochemicals,
have
been
found
to
regulate
various
cellular
signaling
pathways
associated
with
system.
The
main
objective
this
comprehensive
review
is
explore
neuroprotective
effects
isoflavones,
elucidate
underlying
mechanisms,
assess
their
potential
for
treating
neurodegenerative
disorders.
Relevant
data
regarding
isoflavones
impact
on
were
gathered
from
multiple
library
databases
electronic
sources,
including
PubMed,
Google
Scholar,
Web
Science,
Science
Direct.
Numerous
genistein,
daidzein,
biochanin
A,
formononetin,
exhibited
potent
properties
against
diseases.
These
compounds
modulate
neurotransmitters,
in
turn
contributes
ability
protect
neurodegeneration.
Both
vitro
vivo
experimental
studies
provided
evidence
neuroprotection
involve
interactions
estrogenic
receptors,
antioxidant
effects,
anti-inflammatory
properties,
anti-apoptotic
activity,
modulation
neural
plasticity.
This
aims
provide
current
insights
into
characteristics
shed
light
therapeutic
applications
future
clinical
scenarios.
Nutrients,
Год журнала:
2024,
Номер
16(16), С. 2580 - 2580
Опубликована: Авг. 6, 2024
Background:
Puerarin
is
an
isoflavone
compound
isolated
from
the
roots
of
a
leguminous
plant,
wild
kudzu.
Various
functional
activities
this
in
multiple
diseases
have
been
reported.
However,
effect
and
mechanism
puerarin
improving
blood
pressure
remain
non-elucidated.
Purpose:
The
current
study
was
designed
to
assess
preventive
effects
on
onset
progression
hypertension
verify
hypothesis
that
alleviates
by
inhibiting
ROS/TLR4/NLRP3
inflammasome
signaling
pathway
hypothalamic
paraventricular
nucleus
(PVN)
salt-induced
prehypertensive
rats.
Methods:
Male
Dahl
salt-sensitive
rats
were
fed
low
NaCl
salt
(3%
drinking
water)
for
control
(NS)
group
or
8%
(HS)
induce
prehypertension.
Each
batch
divided
into
two
treated
bilateral
PVN
microinjection
with
either
artificial
cerebrospinal
fluid
through
micro-osmotic
pump
6
weeks.
mean
arterial
(MAP)
recorded,
samples
collected
analyzed.
Results:
We
concluded
significantly
prevented
elevation
effectively
alleviated
increase
heart
rate
caused
high
salt.
Norepinephrine
(NE)
plasma
also
decreased
upon
chronic
infusion.
Additionally,
analysis
sample
revealed
pretreatment
positive
cells
gene
level
TLR4
(Toll-like
receptor
4),
NLRP3,
Caspase-1
p10,
NOX2,
MyD88,
NOX4,
proinflammatory
cytokines
PVN.
NF-κBp65
activity,
inhibited
oxidative
stress,
inflammatory
responses
Conclusion:
conclude
via
inhibition
PVN,
suggesting
therapeutic
potential
prevention
hypertension.
Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Фев. 28, 2023
Central
nervous
system
(CNS)
disorders
exhibit
complex
neurophysiological
and
pathological
mechanisms,
which
seriously
affect
the
quality
of
life
in
patients.
Acupuncture,
widely
accepted
as
complementary
alternative
medicine,
has
been
proven
to
exert
significant
therapeutic
effects
on
CNS
diseases.
As
a
part
innate
immune
system,
NLRP3
inflammasome
contributes
pathogenesis
diseases
via
regulating
neuroinflammation.
To
further
explore
mechanisms
acupuncture
diseases,
our
study
focused
neuroinflammation
vascular
dementia,
Alzheimer’s
disease,
stroke,
depression,
spinal
cord
injury.
This
confirmed
that
activation
promotes
development
inhibiting
is
potential
key
target
for
treatment
In
addition,
it
concluded
alleviates
by
pathway,
thereby
improving
progression
provides
theoretical
basis
attenuate
improve
Deleted Journal,
Год журнала:
2024,
Номер
5(1), С. 200137 - 200137
Опубликована: Март 1, 2024
Extensive
global
research
has
been
conducted
to
explore
the
neural
mechanisms
involved
in
acupuncture
treatment
for
central
nervous
system
(CNS)
disorders.
However,
there
is
a
lack
of
bibliometric
analysis
specifically
focusing
on
functional
magnetic
resonance
imaging
(fMRI)
studies
examining
effects
CNS
diseases.
This
study
aims
fill
this
gap
by
offering
theoretical
framework
current
clinical
application
and
future
directions.
It
presents
comprehensive
overview
state,
hotspots,
trends
fMRI
therapeutic
applications
potential
diseases
over
past
two
decades.
The
publications
were
analyzed
using
VOSviewer
1.6.18
CiteSpace
6.1.R6
software
running
Java
platform.
All
acquired
from
Science
Citation
Index-Expanded
Web
Core
Collection.
document
types
limited
original
articles
review
articles,
with
publication
dates
spanning
October
24,
2003
2023.
Only
written
English
language
considered
analysis.
advantages
non-invasiveness,
high
spatial
resolution,
signals
directly
activity
brain.
Compared
other
three
brain
techniques,
most
significant
decades,
substantial
increase.
As
2023,
227
records
identified.
Notably,
discernible
upward
trend
exists
domain's
overall
number
annual
publications.
worth
highlighting
that
China
emerged
as
primary
contributor
field.
five
prominent
topics
explored
encompassed
concepts
"acupuncture,"
"fMRI,"
"electroacupuncture,"
"functional
connectivity,"
"stimulation."
Furthermore,
frontier
areas
investigation
"migraine
without
aura,"
"ischemic
stroke,"
"prophylaxis,"
"randomized
controlled
trial."
have
applications,
topic
expected
increase
rapidly
research.
Future
will
focus
migraine
aura,
ischemic
stroke,
randomized
trials.
connected
various
areas,
default
mode
network.
In
addition,
strengthening
collaboration
among
different
academic
groups
across
countries
imperative.
