Histone lactylation protects against sevoflurane-induced cognitive impairment by regulating YTHDF3/PRDX3 mediated microglial pyroptosis in neonatal mice
International Immunopharmacology,
Год журнала:
2025,
Номер
151, С. 114269 - 114269
Опубликована: Фев. 28, 2025
Язык: Английский
Effects of electroacupuncture on postoperative cognitive dysfunction and its underlying mechanisms: a literature review of rodent studies
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Март 26, 2024
With
the
aging
of
population,
health
elderly
has
become
increasingly
important.
Postoperative
cognitive
dysfunction
(POCD)
is
a
common
neurological
complication
in
patients
following
general
anesthesia
or
surgery.
It
characterized
by
decline
that
may
persist
for
weeks,
months,
even
longer.
Electroacupuncture
(EA),
novel
therapy
combines
physical
nerve
stimulation
with
acupuncture
treatment
from
traditional
Chinese
medicine,
holds
potential
as
therapeutic
intervention
preventing
and
treating
POCD,
particularly
patients.
Although
beneficial
effects
EA
on
POCD
have
been
explored
preclinical
clinical
studies,
reliability
limited
methodological
shortcomings,
underlying
mechanisms
remain
largely
unexplored.
Therefore,
we
synthesized
existing
evidence
proposed
biological
neuroinflammation,
oxidative
stress,
autophagy,
microbiota-gut-brain
axis,
epigenetic
modification.
This
review
summarizes
recent
advances
provides
theoretical
foundation,
explores
molecular
prevention
offers
basis
conducting
relevant
trials.
Язык: Английский
Nanomaterial-Based Strategies for Attenuating T-Cell-Mediated Immunodepression in Stroke Patients: Advancing Research Perspectives
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5793 - 5812
Опубликована: Июнь 1, 2024
Abstract:
This
review
article
discusses
the
potential
of
nanomaterials
in
targeted
therapy
and
immunomodulation
for
stroke-induced
immunosuppression.
Although
have
been
extensively
studied
various
biomedical
applications,
their
specific
use
studying
addressing
immunosuppression
after
stroke
remains
limited.
Stroke-induced
neuroinflammation
is
characterized
by
T-cell-mediated
immunodepression,
which
leads
to
increased
morbidity
mortality.
Key
observations
related
immunodepression
stroke,
including
lymphopenia,
T-cell
dysfunction,
regulatory
imbalance,
cytokine
dysregulation,
are
discussed.
Nanomaterials,
such
as
liposomes,
micelles,
polymeric
nanoparticles,
dendrimers,
offer
advantages
precise
delivery
drugs
T
cells,
enabling
enhanced
targeting
controlled
release
immunomodulatory
agents.
These
modulate
function,
promote
neuroregeneration,
restore
immune
responses,
providing
new
avenues
treatment.
However,
challenges
biocompatibility,
stability,
scalability,
clinical
translation
need
be
addressed.
Future
research
efforts
should
focus
on
comprehensive
studies
validate
efficacy
safety
nanomaterial-based
interventions
cells
Collaborative
interdisciplinary
approaches
necessary
advance
field
translate
these
innovative
strategies
into
practice,
ultimately
improving
outcomes
patient
care.
Keywords:
ischemic
neuroinflammation,
immunosuppression,
nanoparticles
Язык: Английский
Regulation of Postoperative Cognitive Dysfunction by Glutathione Under Various Pathways: A Narrative Review
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(2)
Опубликована: Фев. 1, 2025
Postoperative
cognitive
dysfunction
(POCD)
is
a
common
neurological
complication
after
surgery
and
general
anesthesia,
the
incidence
increases
with
age.
Will
have
negative
impact
on
patients,
family
society.
At
present,
neuroinflammation
oxidative
stress
are
main
recognized
mechanisms.
Glutathione
(GSH)
powerful
reducing
agent
may
be
related
to
POCD.
Using
medical
search
engines
such
as
PubMed,
Web
of
Science,
we
analyzed
articles
topics
as:
POCD,
GSH,
microglia,
astrocyte,
oligodendrocyte,
ferroptosis,
BDNF,
Neuroinflammation,
stress.
The
above
searched
in
databases
using
Boolean
operations.
We
included
original
articles,
reviews
other
article
types
books.
According
reviewed
literature,
GSH
treatment
for
Specific
targeted
therapies
POCD
still
sparse,
therefore,
implementation
preventive
strategies
appears
remain
optimal
attitude.
Further
research
needed
better
understanding
Язык: Английский
Updated insights into the NLRP3 inflammasome in postoperative cognitive dysfunction: emerging mechanisms and treatments
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Сен. 30, 2024
Postoperative
cognitive
dysfunction
(POCD)
poses
a
significant
threat
to
patients
undergoing
anesthesia
and
surgery,
particularly
elderly
patients.
It
is
characterized
by
diminished
functions
post
such
as
impaired
memory
decreased
concentration.
The
potential
risk
factors
for
POCD
include
age,
surgical
trauma,
anesthetic
type,
overall
health
condition;
however,
the
precise
mechanisms
underlying
remain
elusive.
Recent
studies
suggest
that
neuroinflammation
might
be
primary
pathogenic
factor.
NOD-,
LRR-
pyrin
domain-containing
protein
3
(NLRP3)
inflammasomes
are
implicated
in
exacerbating
promoting
release
of
inflammatory
proteins
initiate
pyroptosis,
further
influencing
disease
process.
regulation
NLRP3
inflammasome
activity,
including
its
activation
degradation,
tightly
controlled
through
multiple
pathways
mechanisms.
In
addition,
autophagy,
protective
mechanism,
regulates
control
progression
POCD.
This
review
reviews
recent
findings
on
role
pathogenesis
discusses
therapeutic
strategies
aimed
at
reducing
sources,
inhibiting
cellular
enhancing
autophagy.
Язык: Английский
ML365 ameliorates postoperative cognitive impairment in aged mice by inhibiting NLRP3 inflammasome activation in the hippocampus
Brain Research,
Год журнала:
2024,
Номер
1837, С. 148957 - 148957
Опубликована: Апрель 24, 2024
The
aim
of
this
study
was
to
examine
the
effects
ML365,
a
two-pore
potassium
channel
(K2P)
inhibitor,
on
postoperative
cognitive
impairment
(POCD).
A
mouse
model
POCD
constructed
by
subjecting
aged
C57BL/6
mice
exploratory
laparotomy.
Changes
in
function
were
assessed
using
Morris
water
maze
test.
Western
blotting
and
qPCR
used
detect
hippocampal
NLRP3,
Caspase-1
IL-1β
expression
levels
days
3
7
post-surgery.
Apoptosis-associated
speck-like
protein
containing
caspase
recruitment
domain
(ASC)
level
also
western
blotting.
Pathological
changes
nerve
damage
CA1
CA3
regions
detected
H&E
staining,
while
concentration
malondialdehyde
(MDA)
plasma
measured.
We
found
that
pretreatment
with
ML365
(administered
intraperitoneally
at
dose
10
mg/kg)
30
min
prior
laparotomy
effectively
ameliorated
mice.
reduced
Caspase-1,
ASC
hippocampus,
improved
POCD-induced
pathological
areas
mice,
decreased
MDA
oxidative
stress.
Together,
our
findings
indicate
can
alleviate
inhibiting
NLRP3
inflammasome
activation
hippocampus.
Язык: Английский
The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
Open Medicine,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 1, 2024
Abstract
Background
Postoperative
cognitive
dysfunction
(POCD)
frequently
occurs
following
endovascular
therapy
for
acute
ischemic
stroke
(AIS).
Given
the
complexity
of
predicting
AIS
clinically,
there
is
a
pressing
need
to
develop
preemptive
prediction
model
and
investigate
impact
anesthesia
depth
on
AIS.
Methods
A
total
333
patients
diagnosed
with
were
included
in
study,
comprising
individuals
non-POCD
(
n
=
232)
or
POCD
101).
Univariate
multivariate
logistic
regression
analyses
utilized
examine
independent
risk
factors
associated
POCD.
calibration,
decision
curve
analysis,
precision–recall
curves
employed
assess
model’s
goodness
fit.
Results
Multivariate
analysis
identified
two
inflammatory
indicators,
high-sensitivity
C
reactive
protein
(hs-CRP)
systemic
immune
index
(SII),
three
brain
injury
National
Institute
Health
Stroke
Scale
(NIHSS)
score,
N-terminal
pro-brain
natriuretic
peptide
(NT-proBNP),
soluble
protein-100
β
(S100-β),
which
used
construct
nomogram
model.
Conclusion
The
composite
predictive
incorporating
NIHSS
hs-CRP,
SII,
NT-proBNP,
S100-β
demonstrated
efficacy
Additionally,
our
results
suggest
potential
association
between
anesthesia,
impairment,
response
patients.
Язык: Английский
Arketamine alleviates cognitive impairments and demyelination in mice with postoperative cognitive dysfunction via TGF-β1 activation
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Год журнала:
2024,
Номер
136, С. 111228 - 111228
Опубликована: Дек. 22, 2024
Postoperative
cognitive
dysfunction
(POCD)
is
characterized
by
a
decline
in
functions,
including
memory,
attention,
and
executive
abilities,
following
surgery,
with
no
effective
therapeutic
drugs
currently
available.
Arketamine,
the
(R)-enantiomer
of
ketamine,
has
shown
promise
mitigating
deficits
animal
models.
In
this
study,
we
investigated
whether
arketamine
could
ameliorate
mouse
model
POCD,
focus
on
role
transforming
growth
factor
(TGF)-β1
its
effects.
POCD
mice
displayed
impairments
demyelination
corpus
callosum.
A
single
injection
(10
mg/kg)
significantly
improved
both
function
callosum
mice.
Notably,
pretreatment
RepSox
mg/kg),
TGF-β
receptor
1
inhibitor,
blocked
beneficial
effects
demyelination.
Moreover,
intranasal
administration
TGF-β1
(3.0
μg/kg)
markedly
alleviated
These
findings
suggest
that
exerts
through
TGF-β1-dependent
mechanism,
positioning
it
as
potential
option
for
POCD.
Язык: Английский