Asian Journal of Surgery, Год журнала: 2023, Номер 46(12), С. 5671 - 5673
Опубликована: Авг. 28, 2023
Язык: Английский
European journal of medical research, Год журнала: 2023, Номер 28(1)
Опубликована: Июнь 14, 2023
Apolipoprotein F (APOF) has been less studied in cancers. Thus, we aimed to perform a pan-cancer analysis of the oncogenic and immunological effects APOF on human cancer.A standardized TCGA dataset was downloaded. Differential expression, clinical prognosis, genetic mutations, immune infiltration, epigenetic modifications, tumor stemness heterogeneity were analyzed. We conducted all analyses through software R (version 3.6.3) its suitable packages.Overall, found that common cancers differentially expressed between normal samples prognostic-associated BRCA, PRAD, KIRP, LIHC terms overall survival (OS), disease-free (DFS) progression-free (PFS). The Spearman showed mRNA expression negatively correlated with four indexes (DMPss, DNAss, ENHss, EREG-METHss) statistical significance for PRAD positively LIHC. In BRCA patients, negative correlation TMB, MSI, neo, HRD LOH. mutation frequencies 0.3%. infiltration purity patients. associated most TILs LIHC, B cells, CD4+ T neutrophils, macrophages dendritic but CD8+ cells.Our study offered relatively comprehensive understanding roles
Язык: Английский
Процитировано
7
Clinical Genitourinary Cancer, Год журнала: 2024, Номер 22(3), С. 102061 - 102061
Опубликована: Фев. 29, 2024
Язык: Английский
Процитировано
2
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Апрель 25, 2024
Abstract Background Within the tumor microenvironment, endothelial cells hold substantial sway over bladder cancer (BC) prognosis. Herein, we aim to elucidate impact of on BC patient outcomes by employing an integration single-cell and bulk RNA sequencing data. Methods All data utilized in this study were procured from online databases. R version 3.6.3 relevant packages harnessed for development validation endothelial-associated prognostic index (EPI). Results EPI was formulated, incorporating six genes (CYTL1, FAM43A, GSN, HSPG2, RBP7, SLC2A3). demonstrated significant value both The Cancer Genome Atlas (TCGA) externally validated dataset. Functional results revealed a profound association between cell functionality, as well immune-related processes. Our findings suggest that patients with low-risk scores are more likely respond positively immunotherapy, indicated immune checkpoint activity, infiltration, mutational burden, stemness index, TIDE, IMvigor210 analyses. Conversely, individuals high-risk exhibited heightened sensitivity cisplatin, docetaxel, gemcitabine treatment regimens. Conclusion We have effectively discerned pivotal perspective constructed patients, thereby offering promising prospects precision medicine.
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 7, 2024
Gremlin 1 (GREM1) can regulate the development of many cancers. However, a few studies have revealed role GREM1 in bladder cancer (BC). To evaluate expression and potential function cancer, we used R version 3.6.3 related packages to analyze data from common databases. Samples our institution were assessed by immunohistochemical staining (IHC), which was approved Institutional Ethics Committee (K20220830). highly expressed BC tissues according TCGA IHC data. Data TCGA, GSE31684, GSE32894, showed that has significant prognostic value for patients. is involved immune metabolism-related pathways. According TIDE algorithm, 61.0% patients with low responded well immunotherapy, compared only 13.3% high group. High associated sensitivity cisplatin, docetaxel, gemcitabine, vinblastine. Thus, predict prognosis responses immunotherapy chemotherapy patients, making it biomarker therapeutic target.
Язык: Английский
Процитировано
1
Molecular and Cellular Probes, Год журнала: 2024, Номер 78, С. 101989 - 101989
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
Therapeutic Advances in Medical Oncology, Год журнала: 2024, Номер 16
Опубликована: Янв. 1, 2024
Background: Repeat transurethral resection of bladder tumour (reTURB) is a conventional treatment for non-muscle-invasive cancer (NMIBC) to enhance prognosis. However, the necessity reTURB in NMIBC remains controversial owing upstaging treatments and new evidence. Objectives: We performed an umbrella review determine need patients with NMIBC. Design: extracted data from meta-analyses that were screened out after systematic search PubMed, Embase, Web Science Cochrane Database Systematic Reviews. Methods: Risk Bias Reviews Grading Recommendations, Assessment, Development Evaluation tools used assess quality each included meta-analysis outcomes. Results: Our study seven meta-analyses. Two studies assessed efficiency who underwent en bloc tumours (ERBT). Patients ERBT reported low residual rates 5.9% 0.3%, respectively. Conversely, (cTURB) had high rates. cTURB significantly improved 1-year recurrence-free survival (RFS) compared those initial alone. In terms progression-free (PFS), PFS subgroup analyses ERBT, did not affect RFS received ERBT. Currently, only limited number randomised clinical trials have evaluated reTURB, various factors influenced its efficacy. Conclusion: There was significant variation outcomes among undergoing reTURB. The efficacy depend on numerous factors, such as surgical approach, equipment medication usage. eligible may constitute group does require Further are required validate these findings. Registration: This registered International Prospective Register (CRD42023439078).
Язык: Английский
Процитировано
1
Discover Oncology, Год журнала: 2023, Номер 14(1)
Опубликована: Авг. 25, 2023
Cellular senescence is growing in popularity cancer. A dual function played by the senescence-associated secretory phenotype (SASP) that senescent cells produce development of pro-inflammatory niches, tissue regeneration or destruction, propagation, and malignant transformation. In this study, we conducted thorough bioinformatic analysis meta-analysis to discover detrimental beneficial subtypes prognostic index for prostate cancer (PCa) patients using experimentally confirmed SASP genes.We identified differentially expressed prognosis-related genes used them construct two molecular risk score. Another external cohorts were confirm effect above score was further conducted. Additionally, functional analysis, tumor stemness heterogeneity microenvironment also evaluated. We completed analyses software R 3.6.3 its suitable packages. Meta-analysis performed Stata 14.0.Through multivariate Cox regression consensus clustering VGF, IGFBP3 ANG establish TCGA cohort, which validated through other independent cohorts. showed group had significantly higher biochemical recurrence (BCR) than (HR: 2.48). Moreover, constructed based on these better guide clinical practice. DNA repair, MYC target, oxidative phosphorylation, proteasome ribosome highly enriched group. Detrimental levels B cells, CD8+ T homologous recombination deficiency, loss heterozygosity, microsatellite instability, purity, mutation burden, mRNAsi, methylated probes epigenetically regulated RNA expression The top between groups SPOP, FOXA1, KMT2C, APC, BSN, DNAH17, MYH6, EPPK1, ZNF536 ZC3H13 with statistical significance.From perspective SASP, found closely associated BCR-free survival PCa patients, might be important furture research field PCa.
Язык: Английский
Процитировано
3
Asian Journal of Surgery, Год журнала: 2023, Номер 46(11), С. 5379 - 5381
Опубликована: Сен. 4, 2023
Язык: Английский
Процитировано
2
Asian Journal of Surgery, Год журнала: 2023, Номер 46(11), С. 5373 - 5375
Опубликована: Сен. 6, 2023
Язык: Английский
Процитировано
1
BMC Cancer, Год журнала: 2024, Номер 24(1)
Опубликована: Июнь 14, 2024
Abstract Background Considering the age relevance of prostate cancer (PCa) and involvement cGAS-STING pathway in aging cancer, we aim to classify PCa into distinct molecular subtypes identify key genes from novel perspective pathway. It is significance guide personalized intervention cancer-targeting therapy based on genetic evidence. Methods The 430 patients with TCGA database were included. We integrated 29 involved analyzed differentially expressed biochemical recurrence (BCR)-free survival-related genes. assessments tumor stemness heterogeneity microenvironment (TME) conducted reveal potential mechanisms. Results classified two using AURKB, TREX1, STAT6, subtype 1 had a worse prognosis than 2 (HR: 21.19, p < 0.001). findings validated MSKCC2010 cohort. Among 2, top ten mutation MUC5B, DNAH9, SLC5A10, ZNF462, USP31, SIPA1L3, PLEC, HRAS, MYOM1, ITGB6. Gene set variation analysis revealed high enrichment E2F target 1, gene showed significant base excision repair, cell cycle, DNA replication 1. TME evaluation indicated that significantly higher level T cells follicular helper lower plasma 2. Conclusions mediated by risk score may aid identifying potentially high-risk who benefit pharmacologic therapies targeting
Язык: Английский
Процитировано
0