Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps
European Journal of Pharmacology,
Год журнала:
2024,
Номер
974, С. 176621 - 176621
Опубликована: Апрель 26, 2024
Язык: Английский
Simultaneous Live Mapping of pH and Hydrogen Peroxide Fluctuations in Autophagic Vesicles
JACS Au,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Hydrogen
peroxide
(H2O2)
plays
a
critical
role
in
the
regulation
and
progress
of
autophagy,
an
essential
recycling
process
that
influences
cellular
homeostasis
stress
response.
Autophagy
is
characterized
by
formation
intracellular
vesicles
analogous
to
recycle
"bags"
called
autophagosomes,
which
fuse
with
lysosomes
form
autolysosomes,
eventually
ending
up
as
lysosomes.
We
have
developed
two
novel
autophagic
vesicle-targeted
peptide-based
sensors,
ROSA
for
H2O2
pHA
pH,
simultaneously
track
pH
dynamics
within
autophagy
advances.
Since
values
progressively
decrease
we
utilized
information
on
vesicular
identify
stages
live
cells.
Fluorescence
intensities
sensor,
ROSA,
compartments
at
different
stages,
were
identified
simultaneous
mapping,
revealed
levels
vary
significantly
progresses,
maximum
autolysosomal
stage.
This
study
provides
first
detailed
observation
fluctuations
throughout
entire
living
mammalian
cells,
offering
insights
into
oxidative
changes
associated
this
vital
process.
Язык: Английский
Neurodegenerative diseases and neuroinflammation-induced apoptosis
Open Life Sciences,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Abstract
Neuroinflammation
represents
a
critical
pathway
in
the
brain
for
clearance
of
foreign
bodies
and
maintenance
homeostasis.
When
neuroinflammatory
process
is
dysregulate,
such
as
over-activation
microglia,
which
results
excessive
accumulation
free
oxygen
inflammatory
factors
brain,
among
other
factors,
it
can
lead
to
an
imbalance
homeostasis
development
various
diseases.
Recent
research
has
indicated
that
numerous
neurodegenerative
diseases
closely
associated
with
neuroinflammation.
The
pathogenesis
neuroinflammation
intricate,
involving
alterations
genes
proteins,
well
activation
inhibition
signaling
pathways.
Furthermore,
inflammation
result
neuronal
cell
apoptosis,
further
exacerbate
extent
disease.
This
article
presents
summary
recent
studies
on
relationship
between
apoptosis
caused
by
aim
identify
link
two
provide
new
ideas
targets
exploring
pathogenesis,
prevention
treatment
Язык: Английский
Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 12, 2025
Photoaging,
the
premature
aging
of
skin
due
to
chronic
ultraviolet
(UV)
exposure,
is
a
growing
concern
in
dermatology
and
cosmetic
science.
While
UV
radiation
known
induce
DNA
damage,
oxidative
stress,
inflammation
cells,
recent
research
unveils
promising
countermeasure:
autophagy.
This
review
explores
intricate
relationship
between
autophagy
photoaging,
highlighting
how
this
cellular
recycling
process
can
mitigate
UV-induced
damage.
We
begin
by
examining
differential
impacts
UVA
UVB
on
cells
role
stress
accelerating
photoaging.
Next,
we
delve
into
molecular
mechanisms
autophagy,
including
its
various
forms
regulatory
pathways.
Central
discussion
autophagy’s
protective
functions,
such
as
clearance
damaged
organelles
proteins,
maintaining
genomic
integrity.
Furthermore,
address
current
challenges
harnessing
for
therapeutic
purposes,
need
selective
inducers
deeper
understanding
context-dependent
effects.
By
synthesizing
advancements
proposing
future
directions,
underscores
potential
modulation
novel
strategy
prevent
treat
comprehensive
analysis
aims
inspire
further
investigation
autophagy-based
interventions,
offering
new
hope
preserving
health
face
environmental
stressors.
Язык: Английский
DJ-1: Potential target for treatment of myocardial ischemia-reperfusion injury
Yanwei Ji,
Xinyu Wen,
He-Peng Tang
и другие.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117383 - 117383
Опубликована: Сен. 3, 2024
Ischemic
heart
disease
(IHD)
is
a
significant
global
health
concern,
resulting
in
high
rates
of
mortality
and
disability
among
patients.
Although
coronary
blood
flow
reperfusion
key
treatment
for
IHD,
it
often
leads
to
acute
myocardial
ischemia-reperfusion
injury
(IRI).
Current
intervention
strategies
have
limitations
providing
adequate
protection
the
ischemic
myocardium.
DJ-1,
originally
known
as
Parkinson's
related
protein,
highly
conserved
cytoprotective
protein.
It
involved
enhancing
mitochondrial
function,
scavenging
reactive
oxygen
species
(ROS),
regulating
autophagy,
inhibiting
apoptosis,
modulating
anaerobic
metabolism,
exerting
anti-inflammatory
effects.
DJ-1
also
required
protective
strategies,
such
preconditioning,
postconditioning,
remote
preconditioning
pharmacological
conditioning.
Therefore,
emerges
potential
target
IRI.
Our
comprehensive
review
delves
into
its
mechanisms
IRI
structural
foundations
underlying
functions.
Язык: Английский
Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy
Journal of Molecular Neuroscience,
Год журнала:
2024,
Номер
74(4)
Опубликована: Ноя. 8, 2024
Язык: Английский
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics
Aging and Disease,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
editorial
provides
an
overview
of
recent
advancements
in
the
understanding
and
treatment
neurological
disorders,
focusing
on
aging,
immunity,
blood
flow,
as
featured
this
special
issue.
The
first
section
explores
importance
identifying
biomarkers
aging
aging-related
diseases,
such
Alzheimer's
Disease,
highlighting
emerging
role
saliva-based
gut-brain
axis
disease
diagnosis
management.
In
subsequent
section,
dysregulated
immune
systems
associated
with
are
discussed,
emphasizing
intricate
landscape
system
during
its
bidirectional
relationship
neuroinflammation.
Additionally,
insights
into
involvement
Myeloid-Derived
Suppressor
Cells
(MDSCs)
Multiple
Sclerosis
(MS)
pathogenesis
presented.
third
examines
microglia
neuroinflammation
various
including
age-related
macular
degeneration
(AMD)
Tuberculous
Meningitis
(TBM).
Furthermore,
therapeutic
potential
stem
cell
extracellular
vesicle-based
therapies
for
stroke
is
explored,
along
molecular
mechanism
how
inflammation
regulates
cerebral
myocardial
ischemia.
Finally,
flow
maintaining
vascular
health
impact
disorders
novel
assessment
methods
optimizing
patient
care.
Overall,
issue
offers
valuable
complex
mechanisms
underlying
identifies
avenues
intervention.
Язык: Английский
Dehydrocorydaline attenuates myocardial ischemia-reperfusion injury via the FoXO signalling pathway: A multimodal study based on network pharmacology, molecular docking, and experimental study
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
337, С. 118738 - 118738
Опубликована: Авг. 31, 2024
Dehydrocorydaline
(DHC),
an
active
component
of
Corydalis
yanhusuo
(Y.H.
Chou
&
Chun
C.
Hsu)
W.T.
Wang
ex
Z.Y.
Su
C.Y.
Wu
(Papaveraceae),
exhibits
protective
and
pain-relieving
effects
on
coronary
heart
disease,
but
the
underlying
mechanism
still
remains
unknown.
Язык: Английский
Dehydrocorydaline Attenuates Myocardial Ischaemia-Reperfusion Injury Via the Foxo Signalling Pathway: A Multimodal Study Based on Network Pharmacology, Molecular Docking, and Experimental Study
Опубликована: Янв. 1, 2024
Язык: Английский
Emerging roles of tRNA-derived small RNAs in injuries
PeerJ,
Год журнала:
2024,
Номер
12, С. e18348 - e18348
Опубликована: Окт. 24, 2024
tRNA-derived
small
RNAs
(tsRNAs)
are
a
novel
class
of
noncoding
RNAs,
precisely
cleaved
from
tRNA,
functioning
as
regulatory
molecules.
The
topic
tsRNAs
in
injuries
has
not
been
extensively
discussed,
and
studies
on
entering
new
era.
Here,
we
provide
fresh
perspective
this
topic.
We
systematically
reviewed
the
classification,
generation,
biological
functions
response
to
stress,
well
their
potential
biomarkers
therapeutic
targets
various
injuries,
including
lung
injury,
liver
renal
cardiac
neuronal
vascular
skeletal
muscle
skin
injury.
also
provided
association
between
stress-induced
organ
injury
clinical
perspective.
Язык: Английский