Aging and Disease, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Vascular pathologies are among the most common contributors to neurodegenerative changes across spectrum of normal aging dementia. Cerebral small vessel disease (SVD) encompasses a wide range conditions affecting capillaries, arteries, and arterioles, as well perivascular spaces fluid dynamics in brain, playing significant role vascular contributions cognitive impairment dementia (VCID). These factors can accelerate progression SVD neuronal degeneration. Since is primary risk factor for Alzheimer's (AD) AD-related dementias (ADRD), this Research Topic aims gather recent research better understand healthy age-related impairment. Other include diabetes, lifestyle factors, high cholesterol, inflammation, immune remodeling, all which dysfunction progression. This special issue includes total 21 articles comprising Reviews, Perspectives, Original articles. The cover various technical biological aspects related progress research. We aim promote exchange different fields, including imaging, VCID, molecular biology, neuroinflammation, immunology. Most papers focus on understanding mechanisms AD/ADRD developing new therapeutic strategies.

Язык: Английский