Interplay of cell death pathways and immune responses in ischemic stroke: insights into novel biomarkers DOI
Arian Daneshpour, Zoha Shaka, Nima Rezaei

и другие.

Reviews in the Neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Stroke is a severe neurological disease and major worldwide issue, mostly manifesting as ischemic stroke (IS). In order to create effective treatments for IS, it imperative fully understand the underlying pathologies, existing therapeutic choices are inadequate. Recent investigations have shown complex relationships between several programmed cell death (PCD) pathways, including necroptosis, ferroptosis, pyroptosis, their correlation with immune responses during IS. However, this relationship still unclear. To address gap, review study explored cellular interactions in microenvironment of Then, validate prior findings uncover biomarkers, investigated bioinformatics studies. Several nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), Toll-like receptor 4 (TLR4), receptor-interacting protein kinase (RIPK), were involved PCD-immune interactions. The studies reported key biomarkers such glutathione peroxidase (GPX4), NOD-like family pyrin domain containing 3 (NLRP3), gasdermin D (GSDMD), TLR4, which important implications cuproptosis, necroptosis respectively. These associated PCD mechanisms oxidative stress inflammatory reactions. infiltration analysis consistently revealed significant pathways detrimental cells, neutrophils γδ T cells. Conversely, M2 macrophages helper showed protective effects. conclusion, considering intricate network emphasized necessity paradigm shift approaches injuries that related network.

Язык: Английский

Beyond Pharmacology: The Biological Mechanisms of Remote Ischemic Conditioning in Cerebrovascular Disease DOI Creative Commons
Liya Qin, Fang Tong, Sijie Li

и другие.

Biomolecules, Год журнала: 2024, Номер 14(11), С. 1408 - 1408

Опубликована: Ноя. 5, 2024

Cerebrovascular diseases (CVDs), comprising predominantly ischemic stroke and chronic cerebral hypoperfusion (CCH), are a significant threat to global health, often leading disability mortality. Remote conditioning (RIC) has emerged as promising, non-pharmacological strategy combat CVDs by leveraging the body's innate defense mechanisms. This review delves into neuroprotective mechanisms of RIC, categorizing its effects during acute phases recovery. It also explores synergistic potential RIC when combined with other therapeutic strategies, such pharmacological treatments physical exercise. Additionally, this discusses pathways through which peripheral transmission can confer central neuroprotection. concludes addressing challenges regarding future directions for emphasizing need standardized protocols, biomarker identification, expanded clinical trials fully realize potential.

Язык: Английский

Процитировано

1
Efferocytosis: A new therapeutic target for stroke DOI Creative Commons
Li Gao,

Anatol Manaenko,

Feng Zeng

и другие.

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Abstract Efferocytosis refers to the process that phagocytes recognize and remove apoptotic cells, which is essential for maintaining tissue homeostasis both in physiological pathological conditions. Numerous studies have demonstrated efferocytosis can prevent secondary necrosis proinflammatory factor release, leading resolution of inflammation immunological tolerance numerous diseases such as stroke. Stroke a cause death morbidity adults worldwide. Persistent triggered by dead cells or cell debris major contributor post-stroke brain damage. Effective might be an efficient strategy minimize restore neuronal regeneration function recovery. In this review, we will discuss brain, molecular mechanisms underlying efferocytosis, role resolution, potential therapeutic applications targeting

Язык: Английский

Процитировано

0
Interplay of cell death pathways and immune responses in ischemic stroke: insights into novel biomarkers DOI
Arian Daneshpour, Zoha Shaka, Nima Rezaei

и другие.

Reviews in the Neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Stroke is a severe neurological disease and major worldwide issue, mostly manifesting as ischemic stroke (IS). In order to create effective treatments for IS, it imperative fully understand the underlying pathologies, existing therapeutic choices are inadequate. Recent investigations have shown complex relationships between several programmed cell death (PCD) pathways, including necroptosis, ferroptosis, pyroptosis, their correlation with immune responses during IS. However, this relationship still unclear. To address gap, review study explored cellular interactions in microenvironment of Then, validate prior findings uncover biomarkers, investigated bioinformatics studies. Several nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), Toll-like receptor 4 (TLR4), receptor-interacting protein kinase (RIPK), were involved PCD-immune interactions. The studies reported key biomarkers such glutathione peroxidase (GPX4), NOD-like family pyrin domain containing 3 (NLRP3), gasdermin D (GSDMD), TLR4, which important implications cuproptosis, necroptosis respectively. These associated PCD mechanisms oxidative stress inflammatory reactions. infiltration analysis consistently revealed significant pathways detrimental cells, neutrophils γδ T cells. Conversely, M2 macrophages helper showed protective effects. conclusion, considering intricate network emphasized necessity paradigm shift approaches injuries that related network.

Язык: Английский

Процитировано

0