Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review)

Oncology Reports, Год журнала: 2024, Номер 52(6)

Опубликована: Окт. 8, 2024

Collagen type X α1 chain (COL10A1), a gene encoding the α‑1 of collagen, serves key role in conferring tensile strength and structural integrity to tissues. Upregulation COL10A1 expression has been observed different malignancies, including lung, gastric pancreatic cancer, is associated with poor prognosis. The present review provides an updated synthesis evolving biological understanding COL10A1, particular focus on its mechanisms action regulatory functions within context tumorigenesis. For example, it established that increased promotes cancer progression by activating multiple signaling pathways, TGF‑β1/Smad, MEK/ERK focal adhesion kinase thereby inducing proliferation, invasion migration. Additionally, demonstrated induce epithelial‑mesenchymal transition reshapes extracellular matrix tumor Furthermore, basis methyltransferase‑like 3‑mediated N6‑methyladenosine methylation, intricately regulates epitranscriptomic machinery, augmenting oncogenic role. However, although pivotal transcription orchestration growth, question whether would serve as viable therapeutic target remains subject scientific hypothesis requiring rigorous examination. Variables such distinct microenvironments treatment associations necessitate further experimental validation. Therefore, comprehensive assessment functional mechanistic roles may pave way for development innovative strategies.

Язык: Английский

---

Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 27, 2025

Introduction Microsomal triglyceride transfer protein (MTTP) is an essential lipid for the synthesis and secretion of very low density lipoprotein (VLDL) in hepatocytes chylomicrons (CM) intestinal cells. Further researches have revealed that MTTP exerted its functions a variety tissues beyond liver intestine, including heart, neural antigen-presenting Dysregulation expression can lead to many diseases, such as metabolism disorders, insulin resistance cardiovascular diseases. Despite importance, research on cancer limited, with no comprehensive pan-cancer studies available. Methods was explored TIMER 2.0 Sangerbox databases. The pathological stages survival analysis were analyzed via GEPIA Kaplan Meier plotter. gene mutations by cBioPortal database. immune landscape tumor microenvironment(TME) using single-cell sequencing. Based RNA-seq data TCGA, we constructed GSEA enrichment MTTP. We identified pro-tumor anti-ferroptosis gastric (GC) cells vitro vivo experiments, effect TME ferroptosis Results elevated at least 1/3 tumors. High associated poor prognosis most levels significantly correlated three scores (immune, stromal, extimate) checkpoints half types. Single cell sequencing showed mainly expressed macrophages, especially microglia. increased GC knockdown limited proliferation, migration invasion abilities cells, accompanied sensitivity ferroptosis. In addition, analyzing genes single level, found macrophages may be involved process GC. Conclusions Our study emphasizes promising prognostic immunotherapeutic biomarker infiltration diverse regulates providing potential target immunotherapy.

Язык: Английский

---

P4HB, a novel succinated protein, is essential for fumarate-induced cancer metastasis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143885 - 143885

Опубликована: Май 1, 2025

Язык: Английский

---

Molecular signatures of disulfidptosis: interplay with programmed cell death pathways and therapeutic implications in oncology

Cellular & Molecular Biology Letters, Год журнала: 2025, Номер 30(1)

Опубликована: Июнь 2, 2025

Disulfidptosis represents a newly identified form of regulated cell death (RCD) distinct from other well-established RCD pathways. It occurs during periods glucose starvation, specifically when intracellular NADPH is rapidly depleted and the expression Solute Carrier Family 7 Member 11 (SLC7A11) highly upregulated. Cancer cells utilize SLC7A11 to import cystine extracellular environment, subsequently employ convert it into cysteine. In event deficiency or an impairment in its utilization, accumulates within cells. This accumulation results abnormal disulfide bond formation actin cytoskeleton proteins, which turn causes collapse network ultimately triggers disulfidptosis. process uncovers metabolic vulnerability tumors, offering novel perspectives on mechanisms that underlie death. this paper, we provide comprehensive review mechanism disulfidptosis compare similarities differences with common programmed mechanisms, such as apoptosis, autophagy, ferroptosis, cuproptosis. The aim gain more profound understanding characteristics various Understanding correlation between tumors constitutes crucial theoretical foundation for future research endeavors cancer treatment. offers valuable insights could pave way developing treatment strategies lead groundbreaking advancements therapy.

Язык: Английский

---

P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker

Oncogenesis, Год журнала: 2024, Номер 13(1)

Опубликована: Ноя. 23, 2024

Glioblastoma stem cells (GSCs) are pivotal in the recurrence and drug resistance of glioblastoma multiforme (GBM). However, precision therapeutic diagnostic markers for GSCs have not been fully established. Here, using bioinformatics experimental analysis, we identified P4HB, a protein disulfide isomerase, as serum marker that maintains stemness through Wnt/β-catenin signaling pathway. Transcriptional silencing P4HB induces apoptosis diminishes cell-like characteristics GSCs. Treatments with chemical CCF624 or China National Medical Products Administration (NMPA)-approved securinine significantly prolonged survival patient-derived xenograft mouse models, underscoring P4HB's potential target presenting an expedited path to clinical application repurposing. Additionally, elevated levels patient were found correlate disease progression, its utility biomarker promise medicine.

Язык: Английский

---

Exploring the role of ADAMTSL2 across multiple cancer types: A pan-cancer analysis and validated in colorectal cancer

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 9, 2024

Recent studies have established a correlation between ADAMTSL2 (ADAMTS-like 2) and the development of various cancers. This study aims to conduct comprehensive pan-cancer analysis in 37 cancer types investigate its potential role colon rectal adenocarcinoma (COADREAD).

Язык: Английский

---