Mechanisms and Strategies of Immunosenescence Effects on Non-Small Cell Lung Cancer (NSCLC) Treatment: A Comprehensive Analysis and Future Directions

Seminars in Cancer Biology, Год журнала: 2025, Номер 109, С. 44 - 66

Опубликована: Янв. 9, 2025

Язык: Английский

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Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

The aging immune system presents profound challenges, notably through the decline of T cell function, which is critical for effective responses. As age-related changes lead to diminished diversity and heighten immunosuppressive environments, older individuals face increased susceptibility infections, autoimmune diseases, reduced efficacy immunotherapies. This review investigates intricate mechanisms by drives immunosenescence, including suppression, evasion, antigen reactivity, overexpression checkpoint molecules. By delving into innovative therapeutic strategies aimed at rejuvenating populations modifying immunological landscape, we highlight potential enhancing resilience in elderly. Ultimately, our goal outline actionable pathways restoring thereby improving health outcomes facing decline.

Язык: Английский

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Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy

Aging Cell, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Immunotherapy has transformed the landscape of cancer treatment, with T cell-based strategies at forefront this revolution. However, durability these responses is frequently undermined by two intertwined phenomena: cell exhaustion and senescence. While driven chronic antigen exposure in immunosuppressive tumor microenvironment, leading to a reversible state diminished functionality, senescence reflects more permanent, age- or stress-induced arrest cellular proliferation effector capacity. Together, processes represent formidable barriers sustained anti-tumor immunity. In review, we dissect molecular underpinnings senescence, revealing how dysfunctions synergistically contribute immune evasion resistance across range solid tumors. We explore cutting-edge therapeutic approaches aimed rewiring exhausted senescent phenotypes. These include advances checkpoint blockade, engineering "armored" CAR-T cells, senolytic therapies that selectively eliminate novel interventions reinvigorate system's capacity for eradication. By spotlighting emerging target both provide forward-looking perspective on potential harness rejuvenation. This comprehensive review outlines next frontier immunotherapy: unlocking durable overcoming intrinsic aging exhaustion, ultimately paving way transformative breakthroughs.

Язык: Английский

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Role of immunosenescence in impaired wound healing with age

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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