Mitochondrial Transplantation in Brain Disorders: Achievements, Methods, and Challenges DOI Creative Commons

Aurélien Riou,

Aline Broeglin,

Amandine Grimm

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер unknown, С. 105971 - 105971

Опубликована: Дек. 1, 2024

Mitochondrial transplantation is a new treatment strategy aimed at repairing cellular damage by introducing healthy mitochondria into injured cells. The approach shows promise in protecting brain function various neurological disorders such as traumatic injury/ischemia, neurodegenerative diseases, cognitive disorders, and cancer. These conditions are often characterized mitochondrial dysfunction, leading to impaired energy production neuronal death. review highlights promising preclinical studies where has been shown restore function, reduce inflammation, improve motor functions several animal models. It also addresses significant challenges that must be overcome before this therapy can clinically applied. Current efforts these challenges, including advancements isolation techniques, cryopreservation methods, finding an appropriate source, potential delivery routes, discussed. Considering the rising incidence of limited effectiveness current treatments, offers comprehensive overview state research critically assesses remaining obstacles. provides valuable insights could steer future potentially lead more effective treatments for disorders.

Язык: Английский

MEK5–ERK5 pathway mediates mitophagy by regulating Nur77 to promote tumorigenesis of osteosarcoma cells DOI Creative Commons

Jianshu Wang,

Jinxu Xue,

Baijing Ma

и другие.

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Фев. 19, 2025

To investigate the influence of MEK5/ERK5 pathway on mitophagy in osteosarcoma (OS), as well involved molecular mechanisms. The overlapped genes mitophagy-related from MSigDB database and DEGs between metastatic primary OS groups GSE32981 were identified. GSVA pathways analyzed. relationships Nur77 pathways, prognosis, immune infiltrating cells, response gene sets investigated. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) western blotting utilized to assess expression levels MEK5, ERK5, Nur77, PINK1, Parkin. Cellular behaviors mitochondrial potential evaluated via CCK-8, Transwell assay JC-1 staining. Total 4 obtained DEGs, including GABARAPL1, HIF1A, RB1CC1. activity scores 3 exhibited significant differences groups. Importantly, was significantly negatively correlated with a (GOBP MITOPHAGY: R = − 0.48, P 0.02). group remarkedly higher than that (P < 0.001). Patients high had poor AUC values all above 0.615 predicting 1-, 3-, 5-year survival. In addition, closely related numerous activated dendritic mast cells M0 macrophages, chemokines cytokines (all 0.05). is OS, overexpressed MEK5/ERK promotes expression, tumorigenesis function U2OS cells. Cytosporone B implement increased sh-MEK5 group, inhibited weaken membrane caused by MEK5 downregulation, reversed protein markers PINK1 Parkin group. MEK5–ERK5 mediates regulating promote These findings offered promising therapeutic targets for OS.

Язык: Английский

Процитировано

0
Interspecies differences in mitochondria: Implications for cardiac and vascular translational research DOI

Lisa Alibrandi,

Vincenzo Lionetti

Vascular Pharmacology, Год журнала: 2025, Номер unknown, С. 107476 - 107476

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Metabolic reprogramming in T cell senescence: a novel strategy for cancer immunotherapy DOI Creative Commons
Li Liu, Zhao-Zhe Hao, Xi Yang

и другие.

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 9, 2025

Abstract The complex interplay between cancer progression and immune senescence is critically influenced by metabolic reprogramming in T cells. As cells age, especially within the tumor microenvironment, they undergo significant shifts that may hinder their proliferation functionality. This manuscript reviews how alterations contribute to cell discusses potential therapeutic strategies aimed at reversing these changes. We explore interventions such as mitochondrial enhancement, glycolytic inhibition, lipid metabolism adjustments could rejuvenate senescent cells, potentially restoring efficacy suppression. review also focuses on significance of with aging further explores future direction metabolism-based immunotherapy

Язык: Английский

Процитировано

0
Mitochondrial Transplantation in Brain Disorders: Achievements, Methods, and Challenges DOI Creative Commons

Aurélien Riou,

Aline Broeglin,

Amandine Grimm

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер unknown, С. 105971 - 105971

Опубликована: Дек. 1, 2024

Mitochondrial transplantation is a new treatment strategy aimed at repairing cellular damage by introducing healthy mitochondria into injured cells. The approach shows promise in protecting brain function various neurological disorders such as traumatic injury/ischemia, neurodegenerative diseases, cognitive disorders, and cancer. These conditions are often characterized mitochondrial dysfunction, leading to impaired energy production neuronal death. review highlights promising preclinical studies where has been shown restore function, reduce inflammation, improve motor functions several animal models. It also addresses significant challenges that must be overcome before this therapy can clinically applied. Current efforts these challenges, including advancements isolation techniques, cryopreservation methods, finding an appropriate source, potential delivery routes, discussed. Considering the rising incidence of limited effectiveness current treatments, offers comprehensive overview state research critically assesses remaining obstacles. provides valuable insights could steer future potentially lead more effective treatments for disorders.

Язык: Английский

Процитировано

1