The Association of Body Temperature with Longevity: Insights from Historical Cohorts
Anthropological Review,
Год журнала:
2025,
Номер
88(1), С. 61 - 77
Опубликована: Март 28, 2025
Effective
thermoregulation
is
crucial
for
maintaining
homeostasis.
Previous
research
has
suggested
a
link
between
lower
steady-state
body
temperature
and
longevity,
particularly
in
physically
healthy,
nonobese
older
adults.
However,
the
exact
mechanisms
behind
this
relationship
remain
unclear.
Despite
physiological
insights
gained
from
studies
on
temperature,
limited
attention
been
given
to
its
potential
role
as
biomarker
of
longevity
healthy
populations.
This
study
aimed
evaluate
using
historical
data
two
cohorts.
The
longitudinal
cohort
consisted
142
individuals,
followed
25
years
beginning
at
age
45,
while
cross-sectional
included
204
individuals
stratified
into
four
lifespan
categories.
To
examine
agerelated
trends
Page’s
test
was
employed,
ordinal
regression
used.
analysis
revealed
significant
decrease
women
with
age,
men
showed
no
change.
indicated
trend
toward
temperatures
longer
lifespans.
Lower
may
reflect
reduced
metabolic
rate,
thereby
mitigating
oxidative
stress
molecular
damage,
both
which
are
known
drive
aging
limit
lifespan.
Furthermore,
signal
favorable
inflammatory
profile,
could
translate
slower
increased
survival.
observed
sex-specific
differences
thermoregulatory
patterns
raise
important
questions
about
hormonal
influences,
such
estrogen
levels.
Overall,
these
findings
suggest
that
lifetime
be
warranting
further
exploration
mechanistic
underpinnings.
Язык: Английский
Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker for Long-Term Survival in Older Adults at a Mental Health Care Center: A Historical Cohort Analysis
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2509 - 2509
Опубликована: Апрель 7, 2025
Background/Objectives:
Identifying
reliable
biomarkers
for
healthy
aging
and
longevity
is
a
fundamental
challenge
in
research
medical
sciences.
The
neutrophil-to-lymphocyte
ratio
(NLR)
readily
measurable
indicator
of
immune
balance
that
reflects
the
interplay
between
innate
activation
adaptive
suppression.
Methods:
This
study
examined
NLR
values
204
physically
residents
(98
men
106
women)
stratified
into
four
lifespan
categories
based
on
death
certificates.
Page's
test
ordinal
regression
(Cumulative
Link
Model)
were
used
to
assess
trends
with
longevity.
Results:
In
men,
downward
trend
was
observed.
women,
significant
age-related
decline
identified,
longer-lived
individuals
showing
notably
lower
compared
their
shorter-lived
counterparts.
findings
suggest
associated
longer
survival,
particularly
older
reflecting
superior
regulation
reduced
systemic
inflammation.
Conversely,
elevated
may
indicate
dysfunction
heightened
inflammatory
burden.
Conclusions:
results
this
complement
existing
findings,
reinforcing
critical
importance
supporting
These
also
underscore
potential
as
robust
biomarker
evaluating
function
anticipating
resilience
decline,
offering
practical
tool
assessing
health
population.
Язык: Английский