Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans

Immunity & Ageing, Год журнала: 2024, Номер 21(1)

Опубликована: Авг. 2, 2024

Proteostasis is a critical aging hallmark responsible for removing damaged or misfolded proteins and their aggregates by improving proteasomal degradation through the autophagy-lysosome pathway (ALP) ubiquitin-proteasome system (UPS). Research on impact of heat-killed probiotic bacteria structural components hallmarks innate immune responses scarce, yet enhancing these effects could potentially delay age-related diseases.

Язык: Английский

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Meptyldinocap induces implantation failure by forcing cell cycle arrest, mitochondrial dysfunction, and endoplasmic reticulum stress in porcine trophectoderm and endometrial luminal epithelial cells

The Science of The Total Environment, Год журнала: 2024, Номер 924, С. 171524 - 171524

Опубликована: Март 5, 2024

Язык: Английский

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Beta-cyfluthrin impairs implantation process by inducing mitochondrial defects and changes in reactive oxygen species-mediated signaling pathways in porcine trophectoderm and uterine luminal epithelial cells

The Science of The Total Environment, Год журнала: 2024, Номер 934, С. 173097 - 173097

Опубликована: Май 8, 2024

Язык: Английский

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Punica granatum L. leaf extract enhances stress tolerance and promotes healthy longevity through HLH-30/TFEB, DAF16/FOXO, and SKN1/NRF2 crosstalk in Caenorhabditis elegans

Phytomedicine, Год журнала: 2024, Номер 134, С. 155971 - 155971

Опубликована: Авг. 23, 2024

Punica granatum L., commonly known as pomegranate, is renowned for its health benefits, primarily associated with the consumption of fruit and seeds. However, non-edible parts, including leaves, have been used in traditional medicine a remedy anti-inflammatory anti-diabetic properties. Considering abundance bioactive compounds, predominantly flavonols, flavones, tannins P. leaf (PGL) extract holds potential health-promoting agent. Yet, effect on longevity healthspan remains largely unexplored.

Язык: Английский

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Norflurazon causes cell death and inhibits implantation-related genes in porcine trophectoderm and uterine luminal epithelial cells

Food and Chemical Toxicology, Год журнала: 2024, Номер 186, С. 114559 - 114559

Опубликована: Март 2, 2024

Язык: Английский

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In vitro and in silico assessment of cytotoxicity of dinitramine via calcium dysregulation and mitochondrial dysfunction in bovine mammary glands

Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 205, С. 106152 - 106152

Опубликована: Сен. 25, 2024

Язык: Английский

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Maduramicin ammonium impairs autophagic flux through activating AMPK‐mediated eIF2α‐ATF4 endoplasmic reticulum stress pathway in skeletal muscle

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Maduramicin ammonium (MA), a widely used coccidiostat, has been reported to cause skeletal muscle degeneration in animals and even humans. In this study, we explore the underlying mechanism of its toxicity muscle.

Язык: Английский

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