The Role of MicroRNA, Long Non-Coding RNA and Circular RNA in the Pathogenesis of Polycystic Ovary Syndrome: A Literature Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 903 - 903

Опубликована: Янв. 11, 2024

Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disease in females of reproductive age, affecting 4–20% pre-menopausal women worldwide. MicroRNAs (miRNAs) are endogenous, single-stranded, non-coding, regulatory ribonucleic acid molecules found eukaryotic cells. Abnormal miRNA expression has been associated with several diseases and could possibly explain their underlying pathophysiology. MiRNAs have extensively studied for potential diagnostic, prognostic, therapeutic uses many diseases, such as type 2 diabetes, obesity, cardiovascular disease, PCOS, endometriosis. In miRNAs were to be abnormally expressed theca cells, follicular fluid, granulosa peripheral blood leukocytes, serum, adipose tissue when compared those without making a useful biomarker disease. Key pathways involved folliculogenesis, steroidogenesis, cellular adhesion, regulated by miRNA. This also highlights importance prognostic markers. addition, recent evidence suggests role regulating circadian rhythm (CR). CR crucial reproduction through various functions hypothalamic-pituitary-gonadal (HPG) axis ovaries. A disordered affects outcomes inducing insulin resistance, oxidative stress, systemic inflammation. Moreover, demonstrated interact lncRNA circRNAs, which thought play pathogenesis PCOS. review discusses what currently understood about involved, biomarkers targets.

Язык: Английский

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Exploring the challenges of RNAi-based strategies for crop protection

Advanced Biotechnology, Год журнала: 2024, Номер 2(3)

Опубликована: Июль 15, 2024

RNA silencing (or interference, RNAi) initiated by double-stranded RNAs is a conserved mechanism for regulating gene expression in eukaryotes. RNAi-based crop protection strategies, including host-induced (HIGS), spray-induced (SIGS) and microbe-induced (MIGS), have been successfully used against various pests pathogens. Here, we highlight the challenges surrounding dsRNA design, large-scale production of delivery systems. Addressing these questions will accelerate lab-to-field transition strategies. Moreover, based on studies exogenous dsRNA-induced RNAi inheritance Caenorhabditis elegans, speculate that strategies would confer longer-lasting crops or fungal

Язык: Английский

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tsRNA modifications: An emerging layer of biological regulation in disease

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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How MicroRNAs Command the Battle against Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5865 - 5865

Опубликована: Май 28, 2024

MicroRNAs (miRNAs) are small RNA molecules that regulate more than 30% of genes in humans. Recent studies have revealed miRNAs play a crucial role tumorigenesis. Large sets human tumors under-expressed compared to normal tissues. Furthermore, experiments shown interference with miRNA processing enhances Multiple documented the causal cancer, and miRNA-based anticancer therapies currently being developed. This review primarily focuses on two key points: (1) their cancer (2) regulation tumor suppressors by miRNAs. The discusses (a) suppressor p53 miRNA, (b) critical miR-144/451 cluster regulating Itch-p63-Ago2 pathway, (c) PTEN Future research perspectives also discussed. Understanding these pathways will open avenues for therapeutic interventions targeting regulation.

Язык: Английский

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The bidirectional relationship between periodontitis and diabetes: New prospects for stem cell-derived exosomes

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115219 - 115219

Опубликована: Авг. 1, 2023

Periodontitis and diabetes have a bidirectional link, making therapeutic treatment of periodontitis challenging. Numerous factors, including microbes, inflammatory cytokines, immune cell activity, glucose levels, metabolic disorders, contribute to the relationship diabetes. Basic periodontal treatment, medication, surgical combined are most widely used treatments, but their efficacy limited. Because capacity support bone remodeling tissue regeneration restoration, reduce blood restore islet function, ameliorate local systemic inflammation, stem cell-derived exosomes emerged as possible therapeutic. In this review, we summarize utilization in diabetes,discuss potential mechanisms promoters. It provides some theoretical basis for using regulate link between

Язык: Английский

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Progress of Exosomal MicroRNAs and Traditional Chinese Medicine Monomers in Neurodegenerative Diseases

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

ABSTRACT Exosomes, extracellular vesicles secreted by various cells, actively participate in intercellular communication facilitating the exchange of crucial molecular information such as DNA, RNA, and lipids. Within this intricate network, microRNAs, endogenous non‐coding small RNAs, emerge pivotal regulators post‐transcriptional gene expression, significantly influencing development neurodegenerative diseases. The historical prominence traditional Chinese medicine (TCM) clinical practice China underscores its enduring significance. Notably, TCM monomers, serving active constituents within herbal medicine, assume a critical role treatment diseases, particularly mitigating oxidative stress, inhibiting apoptosis, reducing inflammation. This comprehensive review aims to delineate specific involvement exosomal microRNAs including Alzheimer's disease, Parkinson's Huntington's stroke, amyotrophic lateral sclerosis. Furthermore, exploration extends application elucidating their efficacy therapeutic agents these conditions. Additionally, examines utilization exosomes drug delivery carriers context providing nuanced understanding potential synergies between modern approaches. synthesis knowledge contribute advancement our comprehension mechanisms underlying neurodegeneration avenues offered TCcom interventions.

Язык: Английский

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Integrative RNA, miRNA, and 16S rRNA sequencing reveals immune-related regulation network for glycinin-induced enteritis in hybrid yellow catfish, Pelteobagrus fulvidraco ♀ × Pelteobagrus vachelli ♂

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 15, 2025

Glycinin-induced foodborne enteritis is a significant obstacle that hinders the healthy development of aquatic industry. Glycinin causes growth retardation and intestinal damage in hybrid yellow catfish (Pelteobagrus fulvidraco ♀ × Pelteobagrus vachelli ♂), but its immune mechanisms are largely unknown. In current study, five experimental diets containing 0% (CK), 1.74% (G2), 3.57% (G4), 5.45% (G6), 7.27% (G8) immunological activity glycinin were fed to juvenile reveal mechanism response through RNA microRNA (miRNA) sequencing explore interrelation between molecules microbiota. The results demonstrated content posterior intestine increased significantly linearly with rise dietary levels. More than reduced nutritional digestion absorption function intestine. Notably, an obvious alteration expression levels inflammatory genes (tnf-α, il-1β, il-15, tgf-β1) was observed when exceeded 3.57%. Sequencing miRNA deciphered 4,246 differentially expressed (DEGs) 28 miRNAs (DEmiRNAs) CK G6 groups. Furthermore, enrichment analysis DEGs DEmiRNA target exhibited responses MAPK, NF-κB, WNT pathways following fish exposure glycinin. Additionally, at level diet, obviously inhibited increase microbiota, especially potential probiotics such as Ruminococcus bromii, Bacteroides plebeius, Faecalibacterium prausnitzii, Clostridium clostridioforme. sum, MAPK/NF-κB/WNT pathway induces enteritis, conditions could disrupt micro-ecological equilibrium secreted by host catfish. This study constitutes comprehensive transcriptional perspective how immunity responds excessive intestines.

Язык: Английский

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Identification of serum small non-coding RNA as biomarkers for endometrial receptivity

Genomics, Год журнала: 2025, Номер 117(2), С. 111002 - 111002

Опубликована: Янв. 21, 2025

Язык: Английский

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Non-Coding RNAs: Overview and Roles in Toxicology

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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To explore the role of hsa_circ_0053004/hsa-miR-646/CBX2 in diabetic retinopathy based on bioinformatics analysis and experimental verification

Turkish Journal of Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Abstract Objectives Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM), with risk blindness. The study was to search for effective biomarkers DR. Methods key molecules DR were mined by bioinformatics. Dual luciferase reporter gene assay, knockdown and overexpression assay used detect the regulatory relationship between hsa_circ_0053004, hsa-miR-646, CBX2 , their clinical value evaluated constructing ROC curve. Levels mRNA detected RT-qPCR, western blotting detection protein expression. CCK-8 reagent transwell cell viability migration detection. Results Hsa_circ_0053004 expressed highly in patients, while hsa-miR-646 defective. down-regulated targeting it directly. Hsa-miR-646 inhibited expression its 3′UTR. Overexpression hsa_circ_0053004 or promoted high glucose-induced enhancement human retinal microvascular endothelial (HRMEC) migration, which reversed co-transfection mimic. AUC predicting 0.827, 0.805, 0.817, respectively, combined 0.942. Conclusions adsorbing thereby promoting HRMECs grow migrate, they may be good

Язык: Английский

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