Evaluation of the Anti-Alzheimer Activity of Lycium barbarum Polysaccharide in Aβ1–42-Induced Neurotoxicity in Rat Model DOI Creative Commons

Qingxin Lu,

Y. Gloria Meng,

H. C. Feng

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 226 - 226

Опубликована: Март 26, 2025

As a common neurodegenerative disorder, Alzheimer’s disease (AD) manifests as progressive memory loss, cognitive deficits, and dementia in older adults. the basis of traditional Chinese medicinal herb Goji berries, Lycium barbarum polysaccharide (LBP) has been proven to exhibit multiple pharmacological activities, including antioxidant, neuroprotective, anti-inflammatory effects. Evidence supports that LBP can enhance function holds promise counteracting AD. In order determine neuroprotective effects LBP, this study was conducted on an AD rat model induced by intracerebroventricular injection Aβ1–42 peptides. From 24 h after induction until end behavioral experiment, rats were orally administered (150 300 mg/kg) once day. Neurobehavioral parameters evaluated starting 1 week administration. After tests, euthanized, whole brain cortex isolated detect variations histopathology biochemical parameters. significantly reversed impairments, assessed through Y-maze, Passive Avoidance Test (PAT), Morris water maze (MWM) test, respectively. Furthermore, not only attenuated NFκB, TNF-α, IL-1β, IL-6, AChE, oxidative/nitrosative stress levels but also increased IL-4, IL-10, ACh ChAT activity cortex. HE staining exhibited neuroprotection LBP. Our findings imply may improve mechanisms is potential anti-AD compound.

Язык: Английский

Nano-Delivery Systems for Carotenoids: Enhancing Bioavailability and Therapeutic Potential in Neurodegenerative Diseases DOI
Hazem Golshany, Yang Ni, Qun Yu

и другие.

Food Reviews International, Год журнала: 2025, Номер unknown, С. 1 - 26

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0
Evaluation of the Anti-Alzheimer Activity of Lycium barbarum Polysaccharide in Aβ1–42-Induced Neurotoxicity in Rat Model DOI Creative Commons

Qingxin Lu,

Y. Gloria Meng,

H. C. Feng

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 226 - 226

Опубликована: Март 26, 2025

As a common neurodegenerative disorder, Alzheimer’s disease (AD) manifests as progressive memory loss, cognitive deficits, and dementia in older adults. the basis of traditional Chinese medicinal herb Goji berries, Lycium barbarum polysaccharide (LBP) has been proven to exhibit multiple pharmacological activities, including antioxidant, neuroprotective, anti-inflammatory effects. Evidence supports that LBP can enhance function holds promise counteracting AD. In order determine neuroprotective effects LBP, this study was conducted on an AD rat model induced by intracerebroventricular injection Aβ1–42 peptides. From 24 h after induction until end behavioral experiment, rats were orally administered (150 300 mg/kg) once day. Neurobehavioral parameters evaluated starting 1 week administration. After tests, euthanized, whole brain cortex isolated detect variations histopathology biochemical parameters. significantly reversed impairments, assessed through Y-maze, Passive Avoidance Test (PAT), Morris water maze (MWM) test, respectively. Furthermore, not only attenuated NFκB, TNF-α, IL-1β, IL-6, AChE, oxidative/nitrosative stress levels but also increased IL-4, IL-10, ACh ChAT activity cortex. HE staining exhibited neuroprotection LBP. Our findings imply may improve mechanisms is potential anti-AD compound.

Язык: Английский

Процитировано

0