Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets
World Journal of Gastroenterology,
Год журнала:
2025,
Номер
31(9)
Опубликована: Фев. 18, 2025
Chronic
atrophic
gastritis
(CAG)
is
an
important
stage
of
precancerous
lesions
gastric
cancer.
Effective
treatment
and
regulation
CAG
are
essential
to
prevent
its
progression
malignancy.
Traditional
Chinese
medicine
(TCM)
has
shown
multi-targeted
efficacy
in
treatment,
with
advantages
enhancing
mucosal
barrier
defense,
improving
microcirculation,
modulating
inflammatory
immune
responses,
promoting
lesion
healing,
etc.
Clinical
studies
meta-analyses
indicate
that
TCM
provides
significant
benefits,
specific
herbal
compounds
monomers
demonstrating
protective
effects
on
the
mucosa
through
mechanisms
including
anti-inflammation,
anti-oxidation,
cellular
proliferation
apoptosis,
Finally,
it
pointed
out
requires
standardized
research
unified
standards,
constantly
clarifies
improves
evaluation
criteria
each
dimension
function.
Язык: Английский
Research on drug treatment and the novel signaling pathway of chronic atrophic gastritis
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
176, С. 116912 - 116912
Опубликована: Июнь 7, 2024
Chronic
atrophic
gastritis
(CAG)
is
a
global
digestive
system
disease
and
one
of
the
important
causes
gastric
cancer.
The
incidence
CAG
has
been
increasing
yearly
worldwide.
Язык: Английский
Helicobacter pylori causes gastric dysbacteriosis in chronic gastritis patients
Chao Cen,
Qiuying Du,
Bin Luo
и другие.
Open Life Sciences,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 1, 2024
Abstract
Gastric
mucosal
samples
were
procured
and
underwent
the
sequencing
of
16S
ribosomal
RNA
(16S
rRNA)
via
Illumina
high-throughput
technology
to
explore
impact
Helicobacter
pylori
(
H.
)
infection
on
composition
gastric
flora
in
chronic
gastritis
(CG)
patients.
In
results,
operational
taxonomic
unit
(OTU)
analysis
revealed
an
overlap
5706
OTUs
shared
between
two
groups.
The
top
5
abundance
ranking
(TOP5)
phyla
comprised
Bacteroidetes,
Proteobacteria,
Firmicutes,
Actinobacteria,
Epsilonbacteraeota,
while
TOP5
genus
was
Lachnospiraceae_NK4A136_group
,
Bacteroides
Klebsiella
Pseudomonas
.
metabolic
pathways
at
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)_L3
level,
conspicuous
variations
across
seven
functions
observed
-positive
(HP_Pos)
-negative
(HP_Neg)
Subsequently,
functional
gene
enrichment
KEGG
further
validated
through
animal
experimentation.
contrast
mice
HP_Neg
group,
those
infected
with
manifested
infiltration
inflammatory
cells,
augmentation
acid
secretion,
conspicuously
elevated
scores
regarding
activity,
along
heightened
levels
malondialdehyde.
conclusion,
CG
patients
displayed
a
disorder
flora,
furnishing
theoretical
basis
for
prophylaxis
its
associated
pathogenic
ramifications.
Язык: Английский
The toxic effects of Helicobacter pylori and benzo(a)pyrene in inducing atrophic gastritis and gut microbiota dysbiosis in Mongolian gerbils
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(10), С. 7568 - 7580
Опубликована: Июль 29, 2024
Abstract
Food
chemical
and
microbiological
contamination
are
major
global
food
safety
issues.
This
study
investigated
the
combined
effects
of
food‐borne
pathogen
Helicobacter
pylori
(
H.
)
pollutant
benzo(a)pyrene
(Bap)
on
atrophic
gastritis
gut
microbiota
in
Mongolian
gerbils.
The
results
demonstrated
that
simultaneous
administration
Bap
caused
more
severe
weight
loss,
DNA
damage,
gerbils
compared
with
those
exposed
to
or
alone.
combination
also
significantly
increased
serum
level
proinflammatory
cytokines,
including
IL‐1β
p
<
.05),
IL‐6
.0001),
TNF‐α
.05).
Additionally,
altered
composition
gerbils:
relative
abundance
Lactobacillus
Ligilactobacillus
at
genus
.05)
was
reduced
while
Allobaculum
Erysipelotrichaceae
enhanced
.0001,
Our
revealed
synergy
can
boost
development
lead
dysbiosis
gerbils,
which
provides
essential
implications
for
preventing
contaminated
foods
sustain
life
promote
well‐being.
Язык: Английский