Long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months
Annals of Medicine,
Год журнала:
2025,
Номер
57(1)
Опубликована: Янв. 16, 2025
The
COVID-19
pandemic,
caused
by
SARS-CoV-2,
has
had
profound
global
impacts
since
its
emergence
in
late
2019.
Whilst
acute
symptoms
are
well-documented,
increasing
evidence
suggests
long-term
consequences
extending
beyond
the
phase.
This
study
aimed
to
investigate
cognitive
and
autonomic
effects
of
young
adults.
We
conducted
a
cross-sectional
comparing
adults
with
history
(n
=
34)
matched
controls
34).
Cognitive
function
was
assessed
using
Sternberg
Task,
Stroop
Go/No-Go
Task
(GNG).
Autonomic
evaluated
heart
rate
variability
(HRV)
parameters.
average
time
interval
between
infection
testing
28.2
months.
group
showed
significantly
increased
reaction
2-item
absent
condition
(p
0.044)
errors
4-item
present
0.012)
neutral
response
0.028)
normalized
for
completing
task
0.022)
Task.
No
significant
differences
were
found
GNG
HRV
parameters
did
not
differ
groups,
although
trends
toward
higher
overall
observed
group.
Young
who
approximately
28
months
ago
show
minimal
impact
on
regulation.
However,
subtle
inefficiencies
persist,
particularly
working
memory
executive
tasks.
These
findings
suggest
generally
favorable
prognosis
following
mild
moderate
but
highlight
need
further
investigation
into
persistent
effects.
Язык: Английский
Prevalence, spectrum, and the relations between short-term and long-term post-acute sequelae of COVID-19 in children
Journal of microbiology epidemiology immunobiology,
Год журнала:
2025,
Номер
102(1), С. 43 - 61
Опубликована: Март 30, 2025
Background.
Data
on
the
prevalence
of
post-COVID-19
condition
(PCC)
in
children
differ
due
to
lack
specific
diagnostic
criteria,
reliable
biomarkers,
and
limitations
many
studies.
It
is
important
study
association
between
PCC,
previous
functional
disorders,
any
events
post-acute
period
COVID-19
estimate
true
burden
PCC
children.
The
aim.
To
determine
relation
initial
disorders
during
year
after
a
mild
form
acute
respiratory
tract
infections
(ARTI)
other
etiologies.
Materials
methods.
prospective
using
continuous
sampling
method
included
under
18
years
age
hospitalized
with
suspected
COVID-19,
whom
was
confirmed
by
RT-PCR
(n
=
121)
or
excluded
molecular
serological
methods
(ARTI
group,
n
105).
Information
patients
collected
from
September
2020
December
2021
questionnaires
at
index
points:
hospital
discharge
1,
3,
6
12
months.
Severe
chronic
diseases
were
excluded.
Functional
anamnesis
associated
health
observation,
severity
symptoms
taken
into
account.
analysis
performed
groups
≥
age.
Symptoms
grouped
clusters.
Results.
Any
identified
frequency
32–39%
(in
≥6
years,
respectively).
most
common
psycho-emotional,
autonomic
dysfunction
(AD)
cluster.
cases
duration
3–6
After
adjustment
for
age,
AD
history
recurrent
ARTI
episodes,
no
difference
found
symptom
clusters
except
hyposmia,
incidence
which
decreased
14.3%
first
point
2.4%
one
year.
Among
without
an
year,
de
novo
rare
phenomenon
(2.7–8.0%)
differences
controls.
risks
significantly
increased
(adjusted
OR
1
month
3.19
(95%
CI
1.89–5.38),
months
3.33
1.81–6.15)).
Multiple
(5–25)
persistent
(at
all
points)
rated
as
significant
occurred
rarely
(1.7%
0.4–4.9)),
but
more
often
—
25%)
95%
13.6–39.6%)
(difference
23.3%
(10.9–35.7%),
14.8
(4.4–50.6),
p
0.001).
Recurrent
episodes
risk
factor
increase
cognitive
cluster
complaints
vagotonic
observation.
Conclusion.
results
obtained
indirectly
support
concept
that
somatoform
disorder,
probably
sociogenic
nature,
who
are
anxious
baseline.
Some
consequences
really
need
medical
psychosocial
rehabilitation.
provides
new
insights
widespread
viral
infections.
Язык: Английский
Comparative analysis of the impact of self-reported physical activity on heart rate variability in exposed and nonexposed Individuals to COVID-19: A retrospective study
Medicine,
Год журнала:
2025,
Номер
104(18), С. e42345 - e42345
Опубликована: Май 2, 2025
The
COVID-19
pandemic
has
raised
critical
concerns
about
its
long-term
effects
on
cardiovascular
health,
particularly
concerning
autonomic
nervous
system
(ANS)
function.
Little
is
known
the
differences
in
ANS
function
between
physically
active
and
inactive
individuals
exposed
nonexposed
to
COVID-19.
This
study
aimed
compare
impact
of
self-reported
physical
activity
using
heart
rate
variability
(HRV)
metrics
In
total
142
participants
from
Riyadh
region,
Saudi
Arabia,
were
divided
into
(n
=
70)
71)
groups
based
their
exposure.
HRV
was
assessed
photoplethysmography
analyzed
time
frequency
domains.
Physical
simple
yes
or
no
question,
duration
categorized
less
than
30
minutes,
more
minutes.
Physically
generally
exhibited
higher
metrics,
suggesting
better
function,
although
this
effect
pronounced
group.
Interestingly,
low-frequency
high-frequency
ratio
only
metric
that
showed
a
statistically
significant
difference
group
(
P
.04).
There
reported
either
COVID-19-exposed
groups.
underscored
importance
monitoring
health
post-COVID-19
populations
suggested
while
beneficial,
virus
may
blunted
benefits.
Further
research
needed
explore
implications
potential
for
mitigate
these
effects.
Язык: Английский
Superficial Neuromodulation in Dysautonomia in Women with Post-COVID-19 Condition: A Pilot Study
Brain Sciences,
Год журнала:
2025,
Номер
15(5), С. 510 - 510
Опубликована: Май 16, 2025
Post-COVID-19
condition
involves
persistent
symptoms
after
acute
infection,
often
linked
to
dysautonomia,
which
affects
heart
rate
variability,
pain
perception,
fatigue,
and
sleep.
Superficial
neuromodulation
has
been
proposed
as
a
treatment.
Objective:
To
assess
the
effects
of
superficial
on
symptoms,
sleep
quality,
autonomic
function
in
post-COVID-19
patients.
Methods:
A
pilot
study
was
conducted
based
triple-blind
randomized
controlled
trial
methodology
involving
16
female
participants.
The
experimental
group
received
neuromodulation,
while
control
used
placebo
device.
intervention
spanned
15
sessions
over
two
months.
Primary
outcomes
included
threshold,
cortisol
levels,
quality
life,
analyzed
using
repeated-measures
ANOVA.
Results:
Both
groups
improved
time.
Heart
variability
(SDNN)
increased
(30.42
39.11
ms)
but
decreased
controls
(31.88
28.73
(p
<
0.05).
Pain
threshold
at
C5–C6
(2.1
3.5
kg/cm2)
remained
stable
=
0.032).
Fatigue
significantly
both
0.002).
Sleep
improved,
with
Pittsburgh
Quality
Index
scores
decreasing
similarly
groups.
Cortisol
levels
increased,
non-significant
trend
favoring
controls.
Conclusions:
While
improvements
were
seen,
benefited,
suggesting
possible
effect.
appears
safe,
further
studies
larger
samples
are
needed
confirm
efficacy.
Язык: Английский
Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID
Frontiers in Rehabilitation Sciences,
Год журнала:
2024,
Номер
5
Опубликована: Июль 12, 2024
Introduction
Long
COVID
involves
debilitating
symptoms,
many
of
which
mirror
those
observed
with
dysautonomia,
and
care
must
be
taken
rehabilitation
for
autonomic
dysfunction
to
avoid
post-exertional
malaise/post-exertional
symptom
exacerbation.
Resonant
breathing
(breathing
slowly
at
a
defined
rate
breaths
per
minute)
requires
less
exertion
can
potentially
improve
function.
The
objective
this
work
was
report
on
the
impact
resonant
program
self-reported
symptoms
wellbeing
in
people
COVID.
Methods
A
retrospective
analysis
de-identified
data
completed
convenience
sample
COVID,
who
participated
Meo
Health
(formerly
known
as
Stasis
HP)
program.
Participants
baseline
follow
up
surveys.
Results
Data
were
available
99
participants.
Most
measures
improved
up,
largest
differences
participant
seen
sense
wellness
(47.3%,
p
<
0.0001),
ability
focus
(57.5%,
breathe
(47.5%,
control
stress
(61.8%,
0.0001)
sleep
quality
(34.9%,
=
0.0002).
(92%)
participants
reported
improvement
Patient
Global
Impression
Change
Scale.
Conclusion
Self-reported
completing
breathing.
considered
an
option
within
broader
treatment
plan
Язык: Английский
Impact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 28, 2024
Abstract
This
study
investigated
the
impact
of
mild
COVID-19
on
HRV
in
groups
stratified
by
time
after
infection
and
to
compare
a
healthy
group
same
age
without
previous
virus
need
hospitalization.
is
cross-sectional
study.
We
divided
sample
into
four
groups:
control
(CG)
(
n
=
31),
1
(G1):
≤6
weeks
34),
2
(G2):
2–6
months
30),
3
(G3):
7–12
35)
infection.
For
analysis,
we
used
indices
linear
(time
frequency
domain)
non-linear
analysis.
comparisons
between
groups,
ANOVA
one
way
test
or
Kruskal–Wallis
was
according
data
distribution.
The
effect
size
calculated
based
Cohen’s
d
η
.
Simple
multiple
regressions
were
performed
investigate
interaction
clinical
outcomes
parameters.
A
total
130
individuals
included.
Groups
G1
G2
showed
less
parasympathetic
modulation
when
compared
CG
p
<
0.05),
while
G3
an
increase
0.05).
Moderate
large
sizes
found
Cohen
regression
models
identified
duration
as
significant
predictors
for
RMSSD
(adjusted
R
0.227)
SD1
0.242),
SDNN
0.213).
BMI,
hypertension,
dyslipidemia
non-significant
all
models.
HF
(n.u.),
consistently
significant,
with
stress
emerging
predictor
Model
0.143).
recovery
since
diagnosis
influences
from
HRV,
suggesting
transient
disease
autonomic
nervous
system.
Язык: Английский
COVID-19-Associated Multisystem Inflammatory Syndrome in Children and Cardiovascular Autonomic Control: A Prospective Cohort Study Nine Months after SARS-CoV-2 Infection
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(14), С. 4163 - 4163
Опубликована: Июль 16, 2024
Background:
Multisystem
Inflammatory
Syndrome
in
Children
(MIS-C)
has
emerged
as
a
severe
pediatric
complication
during
the
SARS-CoV-2
pandemic,
with
potential
long-term
cardiovascular
repercussions.
We
hypothesized
that
heart
rate
and
blood
pressure
control
at
rest
postural
maneuvers
MIS-C
patients,
months
after
remission
of
inflammatory
syndrome,
may
reveal
autonomic
dysfunctions.
Methods:
assessed
17
patients
(13
males;
11.9
±
2.6
years,
m
SD)
9
acute
infection
18
age-
(12.5
2.1
years)
sex-
males)
matched
controls.
Heart
variability,
baroreflex
function,
hemodynamic
parameters
were
analyzed
supine
standing
postures.
Results:
exhibited
reduced
particularly
parasympathetic
(pNN50+:
6.1
6.4%
controls,
2.5
3.9%
MIS-C;
RMSSD:
34
19
ms
21
14
MIS-C,
p
<
0.05),
no
interaction
between
case
posture.
Blood
variability
sensitivity
did
not
differ
groups
except
for
high-frequency
power
systolic
(3.3
1.2
mmHg2
1.8
0.05).
The
group
also
showed
lower
diastolic
pressure–time
indices
(DPTI)
(SPTI),
(DPTI:
36.2
9.4
mmHg·s
29.4
6.2
SPTI:
26.5
4.3
23.9
2.4
Conclusions:
Altered
persist
with,
however,
compensatory
mechanisms
help
maintain
homeostasis
light
challenges,
such
maneuvers.
These
results
highlight
importance
assessing
children
to
possibly
identify
residual
risks
inform
targeted
interventions
rehabilitation
protocols.
Язык: Английский